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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Myt1tm1Ggu
targeted mutation 1, Guoqiang Gu
MGI:3765054
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Myt1tm1Ggu/Myt1tm1.1Ggu
Tg(Pdx1-cre)89.1Dam/?
involves: 129 * C57BL/6 * CBA * CD-1 * SJL MGI:3765063


Genotype
MGI:3765063
cn1
Allelic
Composition
Myt1tm1Ggu/Myt1tm1.1Ggu
Tg(Pdx1-cre)89.1Dam/?
Genetic
Background
involves: 129 * C57BL/6 * CBA * CD-1 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myt1tm1.1Ggu mutation (0 available); any Myt1 mutation (57 available)
Myt1tm1Ggu mutation (1 available); any Myt1 mutation (57 available)
Tg(Pdx1-cre)89.1Dam mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• islet cells isolated from 12 week old males secrete a third less insulin in response to high glucose as compared to wild-type controls
• 30 minutes after glucose injection, mice only had a 30% rise in insulin compared to a 100% rise in wild-type mice

endocrine/exocrine glands
• Mafb production in cells producing more than one hormone suggests delayed maturity of the secretory cells of the pancreas
• 10% of pancreatic polypeptide producing cells also express somatostatin which represents a 5 fold increase compared to wild-type controls
• 4.1% of pancreatic polypeptide producing cells also express insulin which represents a 20 fold increase compared to wild-type controls
• 2.7% of glucogon producing cells also produce insulin representing a 10 fold increase over wild-type controls
• islet cells isolated from 12 week old males secrete a third less insulin in response to high glucose as compared to wild-type controls





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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory