About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Cryaa-TAg)7488Lmgd
transgene insertion 7488, Laboratory of Mammalian Genes and Development, Heiner Westphal
MGI:3764829
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(Cryaa-TAg)7488Lmgd/? Not Specified MGI:3764897


Genotype
MGI:3764897
tg1
Allelic
Composition
Tg(Cryaa-TAg)7488Lmgd/?
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• invasive growth of lens breaks through the back of the eye in older animals (>2 months)
• cells of lens masses have characteristics of transformed (tumor) cells including lack of contact inhibition and rapid growth
• at 10-15 days of age, differentiation of fiber cells is affected, with the anaplastic cells (that are present in more advanced tumors ) visualized in the posterior lens compartment
• lens oncogenesis is well-progressed in all mice by 2 to 3 months
• invasive growth of lens eventually breaks through cornea at front of eye
• in animals older than 2 months, lens is replaced by a disorganized mass that has grown outside the lens capsule
• lens (or disorganized mass) has become infiltrated by blood vessels in animals >2 months
• much of lens is composed of small, mitotically active anaplastic cells
• a few large, abnormal differentiated lens cells (balloon cells) are distributed throughout tissue
• by day 12 of embryogenesis, nuclear packing density in posterior region of the vesicle is higher than in control lenses
• mitotically active cells, normally absent in the fiber region, are observed, especially near the lumen; cells near the lumen are round, whereas normal cells are slightly elongated
• by day 13, a disorganized array of small, mitotically active cells have replaced the longitudinally ordered array of primary fiber cells that is seen in normal lenses
• elongated cells are still present at the posterior periphery of the lens at day 13 but they do not persist past this stage; more developed lenses contain only small round cells in posterior compartment
• some normal epithelium cells are present although they are often displaced into the interior of the lens
• a multilayered epithelium is observed in many areas of the lens
• elongated fiber cells seen in normal lens are absent in transgenic lenses

neoplasm
• some animals surviving beyond 5 months of age develop non-lenticular tumors at various sites throughout the body
• cells of lens masses have characteristics of transformed (tumor) cells including lack of contact inhibition and rapid growth
• at 10-15 days of age, differentiation of fiber cells is affected, with the anaplastic cells (that are present in more advanced tumors ) visualized in the posterior lens compartment
• lens oncogenesis is well-progressed in all mice by 2 to 3 months





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
01/14/2020
MGI 6.14
The Jackson Laboratory