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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(HSA*LR)20bCath
transgene insertion 20b, Charles A Thornton
MGI:3763907
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(HSA*LR)20bCath/? involves: FVB/N MGI:3763917


Genotype
MGI:3763917
tg1
Allelic
Composition
Tg(HSA*LR)20bCath/?
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
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phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
• however, mice do not develop muscle weakness or wasting by 6 months of age
• mice exhibit a moderate increase in central nuclei and rare necrotic fibers
• at 18 to 20 days of age, mice exhibit robust myotonic discharges
• myotonia is observed as early as 4 weeks of age when muscle histology is normal
• mice exhibit abnormal hindlimb posture when they initiate movement after long periods of inactivity or when they are suspended by their tails
• 6 of 6 mice display myotonia

Mouse Models of Human Disease
OMIM ID Ref(s)
Myotonic Dystrophy 1; DM1 160900 J:64493





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory