Analysis Tools
normal phenotype
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• mice are equivalent to wild-type mice and used as controls
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Allele Symbol Allele Name Allele ID |
Grk2tm1Gwd targeted mutation 1, Gerald W Dorn II MGI:3763199 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice are equivalent to wild-type mice and used as controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in the lymph nodes
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• in the spleen and blood
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• in the spleen
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• in the spleen
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• B cells and marginal zone B cells exhibit increased chemotactic response to S1P compared with control cells
• long-term accumulation of B cells in the lymph node is reduced compared with control cells
• marginal zone B cells exhibit decreased chemotactic response to CCL21 compared with control cells
• marginal zone B cells exhibit increased chemotactic response to SEW2871 (S1PR1-selective agonist) compared with control cells
• marginal zone B cell relocalization to the follicle induced by FTY720 treatment is delayed compared to in control mice
• splenic follicular dendritic cells exhibit reduced deposition of phycoerythrin-induced complexes compared with control cells
• however, transfer into a S1P null mouse restores normal lymph node accumulation
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• in the lymph nodes
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• in the spleen and blood
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• in the spleen
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• in the spleen
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• B cells and marginal zone B cells exhibit increased chemotactic response to S1P compared with control cells
• long-term accumulation of B cells in the lymph node is reduced compared with control cells
• marginal zone B cells exhibit decreased chemotactic response to CCL21 compared with control cells
• marginal zone B cells exhibit increased chemotactic response to SEW2871 (S1PR1-selective agonist) compared with control cells
• marginal zone B cell relocalization to the follicle induced by FTY720 treatment is delayed compared to in control mice
• splenic follicular dendritic cells exhibit reduced deposition of phycoerythrin-induced complexes compared with control cells
• however, transfer into a S1P null mouse restores normal lymph node accumulation
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• lymph node high endothelial venules exhibit a 3- to 4-fold reduction in T cells undergo the rolling-to-sticking transition compared with controls
• T cells exhibit decreased rolling velocity compared with control cells
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• in the spleen
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• in the lymph nodes and blood but not spleen
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• in the blood and lymph nodes
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• in the blood and lymph nodes
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• T cells exhibit elevated chemotactic response to S1P and decreased response to CCL21 compared with control cells
• T cells exhibit defective entry into the lymph node compared with control cells
• lymph node high endothelial venules exhibit a 3- to 4-fold reduction in T cells undergo the rolling-to-sticking transition compared with controls
• T cells exhibit decreased rolling velocity compared with control cells
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• lymph node high endothelial venules exhibit a 3- to 4-fold reduction in T cells undergo the rolling-to-sticking transition compared with controls
• T cells exhibit decreased rolling velocity compared with control cells
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• in the spleen
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• in the lymph nodes and blood but not spleen
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• in the blood and lymph nodes
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• in the blood and lymph nodes
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• T cells exhibit elevated chemotactic response to S1P and decreased response to CCL21 compared with control cells
• T cells exhibit defective entry into the lymph node compared with control cells
• lymph node high endothelial venules exhibit a 3- to 4-fold reduction in T cells undergo the rolling-to-sticking transition compared with controls
• T cells exhibit decreased rolling velocity compared with control cells
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• lymph node high endothelial venules exhibit a 3- to 4-fold reduction in T cells undergo the rolling-to-sticking transition compared with controls
• T cells exhibit decreased rolling velocity compared with control cells
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• unlike in Adrbk1tm1.1Gwd homozygotes, mice survive into adulthood
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• inotropic and lusitropic tachyphylaxis effects induced by isoproterenol are blunted
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• mice exhibit a leftward shift of the peak +dP/dt response to infused doses of isoproterenol with an EC50 of 0.4+/-0.1 ng/g per minute compared to 0.7+/-0.04 ng/g per minute in Adrbk1tm1Gwd control mice
• when exposed to 30 mg/kg per day isoproterenol, mice develop adverse cardiac remodeling (decreased heart rate, wall thickness to chamber radius ratio) and decreased contractile performance with generalized interstitial and replacement fibrosis in addition to the cardiac dilation and increased left ventricle mass observed in similarly treated Adrbk1tm1Gwd control mice
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| N |
• unlike in Adrbk1tm1.1Gwd homozygotes, heart development is normal
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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