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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Git1Gt(FHCRC-GT-S10-12C1)Sor
gene trap FHCRC-GT-S10-12C1, Philippe Soriano
MGI:3762634
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Git1Gt(FHCRC-GT-S10-12C1)Sor/Git1Gt(FHCRC-GT-S10-12C1)Sor involves: 129S4/SvJaeSor * C57BL/6 MGI:5000121
ht2
Git1Gt(FHCRC-GT-S10-12C1)Sor/Git1+ involves: 129S4/SvJae * C57BL/6 MGI:3762637


Genotype
MGI:5000121
hm1
Allelic
Composition
Git1Gt(FHCRC-GT-S10-12C1)Sor/Git1Gt(FHCRC-GT-S10-12C1)Sor
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Git1Gt(FHCRC-GT-S10-12C1)Sor mutation (2 available); any Git1 mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 50% of mice die postnatally

behavior/neurological
• mice spend less time with a novel object compared with wild-type mice
• however, amphetamine treatment normalizes impaired memory
• in a Morris water maze, mice exhibit impaired learning compared with wild-type mice
• mice exhibit reduced swimming velocity compared with wild-type mice
• 2-fold in an open field at 8 weeks of age
• in a home cage at 8 weeks of age
• however, 7 month old mice exhibit normal locomotor activity and amphetamine-treatment normalizes hyperactivity

nervous system
• the number of parvalbumin neurons in the hippocampal area and cortex is reduced compared to in wild-type mice
• mice exhibit enhanced theta rhythms compared with wild-type mice
• however, amphetamine treatment reversed elevated theta rhythms
• the ratio of field excitatory postsynpatic potential slopes to fiber volley amplitudes is increased compared to in wild-type mice
• however, presynaptic release probability is normal
• mice exhibit decreased miniature inhibitory postsynaptic current (mIPSC) frequency compared with wild-type mice
• however, mIPSC amplitude is normal

growth/size/body
• in surviving mice




Genotype
MGI:3762637
ht2
Allelic
Composition
Git1Gt(FHCRC-GT-S10-12C1)Sor/Git1+
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Git1Gt(FHCRC-GT-S10-12C1)Sor mutation (2 available); any Git1 mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice are normal with no differences in body size, organ size, overt behavior, or fertility when compared to wild-type mice





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory