Phenotypes associated with this allele

• Allele Symbol: Ramp1^tm1.1Tsuj
• Allele Name: targeted mutation 1, Kazutake Tsujikawa
• Allele ID: MGI:3761144
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ramp1^tm1.1Tsuj/Ramp1^tm1.1Tsuj	C.129S2-Ramp1^tm1.1Tsuj	MGI:3761146
hm2	Ramp1^tm1.1Tsuj/Ramp1^tm1.1Tsuj	involves: 129S2/SvPas * C57BL/6	MGI:3761145

Genotype
MGI:3761146

hm1

• Allelic Composition: Ramp1^tm1.1Tsuj/Ramp1^tm1.1Tsuj
• Genetic Background: C.129S2-Ramp1^tm1.1Tsuj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased circulating interferon-gamma level ( J:125974 )

• levels of IFN-gamma are significantly higher than in wild-type mice 24 hours after injection of LPS

increased circulating interleukin-6 level ( J:125974 )

• levels are significantly higher than in wild-type mice 24 hours after injection of LPS

increased circulating tumor necrosis factor level ( J:125974 )

• levels are significantly higher than in wild-type mice 12 hours after injection of LPS

• bone marrow derived DC are refractory to suppressive effects of alpha- and beta-CGRP on tumor necrosis factor production

abnormal cytokine secretion ( J:125974 )

• inflammatory cytokine levels remain elevated for longer after LPS injection

abnormal chemokine secretion ( J:125974 )

• levels of CCL2 are significantly higher than in wild-type mice 24 hours after injection of LPS

homeostasis/metabolism

increased circulating interferon-gamma level ( J:125974 )

• levels of IFN-gamma are significantly higher than in wild-type mice 24 hours after injection of LPS

increased circulating interleukin-6 level ( J:125974 )

• levels are significantly higher than in wild-type mice 24 hours after injection of LPS

increased circulating tumor necrosis factor level ( J:125974 )

• levels are significantly higher than in wild-type mice 12 hours after injection of LPS

• bone marrow derived DC are refractory to suppressive effects of alpha- and beta-CGRP on tumor necrosis factor production

Genotype
MGI:3761145

hm2

• Allelic Composition: Ramp1^tm1.1Tsuj/Ramp1^tm1.1Tsuj
• Genetic Background: involves: 129S2/SvPas * C57BL/6

cardiovascular system

increased systemic arterial systolic blood pressure ( J:125974 )

• mice exhibit 40% higher blood pressure compared to wild-type littermates

• blood pressure increases slightly with age

decreased vasodilation ( J:125974 )

• blood pressure is refractory to administration of some vasodilators (alpha calcitonin gene-related peptide, adrenomedullin)

• relaxation of aortic rings by vasodilators is reduced in ex vivo assays

muscle

decreased vasodilation ( J:125974 )

• blood pressure is refractory to administration of some vasodilators (alpha calcitonin gene-related peptide, adrenomedullin)

• relaxation of aortic rings by vasodilators is reduced in ex vivo assays