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Allele Symbol Allele Name Allele ID |
Unc5btm1Matl targeted mutation 1, Marc Tessier-Lavigne MGI:3760978 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at embryonic day 10
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• at embryonic day 10
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• during embryonic day 10
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• during embryonic day 10
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice die at embryonic day 12.5 death due to heart failure from increased resistance from arterial vasculature
(J:126240)
• Background Sensitivity: on a CD-1 mixed background, mice die at E13.5 compared to E10.5 for mice on a C57BL/6 background
(J:142510)
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• by embryonic day 12.5
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• in E12.5 embryos, capillaries in hindbrains and neural tubes are thinner, have 40% more branch points, and increased filopodial extensions
• capillary morphology does not change upon injection of netrin-1 protein in the hindbrain of E10.5 embryos
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• increase in branching points in the neural tube and hindbrain
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• increased vessel branching of the internal carotid artery, intersomitic vessels, and blood vessels within the nervous system
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• no decreases in apoptosis of endothelial cells, suggesting loss of gene regulates guidance and not survival
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| N |
• mice exhibit normal inner ear formation
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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