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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ankrd23tm1Krc
targeted mutation 1, Kenneth R Chien
MGI:3760785
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ankrd23tm1Krc/Ankrd23tm1Krc involves: 129 * Black Swiss MGI:5605995
cx2
 		Ankrd1tm1Krc/Ankrd1tm1Krc
Ankrd2tm1Krc/Ankrd2tm1Krc
Ankrd23tm1Krc/Ankrd23tm1Krc 		involves: 129 * Black Swiss MGI:3760786


Genotype
MGI:5605995
hm1
Allelic
Composition		 Ankrd23tm1Krc/Ankrd23tm1Krc
Genetic
Background		 involves: 129 * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ankrd23tm1Krc mutation (0 available); any Ankrd23 mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:215212 )
• mice are born at expected Mendelian ratios, are fertile, and survive until adulthood, have normal cardiac morphology and physiology




Genotype
MGI:3760786
cx2
Allelic
Composition		 Ankrd1tm1Krc/Ankrd1tm1Krc
Ankrd2tm1Krc/Ankrd2tm1Krc
Ankrd23tm1Krc/Ankrd23tm1Krc
Genetic
Background		 involves: 129 * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ankrd1tm1Krc mutation (0 available); any Ankrd1 mutation (20 available)
Ankrd23tm1Krc mutation (0 available); any Ankrd23 mutation (6 available)
Ankrd2tm1Krc mutation (0 available); any Ankrd2 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
muscle
abnormal sarcomere morphology ( J:125819 )
• sarcomere length at resting is longer than in wild-type mice
• titin lengths in the sarcomere are longer than in wild-type mice
abnormal muscle physiology ( J:125819 )
• muscles exhibit a greater degree of torque loss after eccentric contraction compared to wild-type mice
• however, muscle recovery is normal

cardiovascular system
cardiovascular system phenotype ( J:215212 )
N
• mice exhibit normal cardiac morphology and function and a normal hypertrophic response to transverse aortic constriction




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory