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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ankrd2tm1Krc
targeted mutation 1, Kenneth R Chien
MGI:3760784
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ankrd2tm1Krc/Ankrd2tm1Krc involves: 129 * Black Swiss MGI:5605990
cx2
Ankrd1tm1Krc/Ankrd1tm1Krc
Ankrd2tm1Krc/Ankrd2tm1Krc
Ankrd23tm1Krc/Ankrd23tm1Krc
involves: 129 * Black Swiss MGI:3760786


Genotype
MGI:5605990
hm1
Allelic
Composition
Ankrd2tm1Krc/Ankrd2tm1Krc
Genetic
Background
involves: 129 * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ankrd2tm1Krc mutation (0 available); any Ankrd2 mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• expression of pro-inflammatory cytokines is upregulated in differentiated myoblasts

muscle
• skeletal muscle appears normal, however the slow twitch-muscle gene expression program is modified, with Il6, Glut4, and Rcan1 downregulated in soleus muscle, indicating that slow muscle fibers are transcripitionally adapted to fiber-type switching toward a faster phenotype

cardiovascular system
N
• mice have normal cardiac morphology and physiology

mortality/aging
N
• mice are born at expected Mendelian ratios, are fertile, and survive until adulthood




Genotype
MGI:3760786
cx2
Allelic
Composition
Ankrd1tm1Krc/Ankrd1tm1Krc
Ankrd2tm1Krc/Ankrd2tm1Krc
Ankrd23tm1Krc/Ankrd23tm1Krc
Genetic
Background
involves: 129 * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ankrd1tm1Krc mutation (0 available); any Ankrd1 mutation (13 available)
Ankrd23tm1Krc mutation (0 available); any Ankrd23 mutation (4 available)
Ankrd2tm1Krc mutation (0 available); any Ankrd2 mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
• sarcomere length at resting is longer than in wild-type mice
• titin lengths in the sarcomere are longer than in wild-type mice
• muscles exhibit a greater degree of torque loss after eccentric contraction compared to wild-type mice
• however, muscle recovery is normal

cardiovascular system
N
• mice exhibit normal cardiac morphology and function and a normal hypertrophic response to transverse aortic constriction





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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory