All Phenotypes Ankrd2<tm1Krc> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ankrd2^tm1Krc
targeted mutation 1, Kenneth R Chien
MGI:3760784

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ankrd2^tm1Krc/Ankrd2^tm1Krc	involves: 129 * Black Swiss	MGI:5605990
cx2	Ankrd1^tm1Krc/Ankrd1^tm1Krc Ankrd2^tm1Krc/Ankrd2^tm1Krc Ankrd23^tm1Krc/Ankrd23^tm1Krc	involves: 129 * Black Swiss	MGI:3760786

Allelic Composition	Ankrd2^tm1Krc/Ankrd2^tm1Krc
Genetic Background	involves: 129 * Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ankrd2^tm1Krc mutation (0 available); any Ankrd2 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal inflammatory response ( J:214867 )

• expression of pro-inflammatory cytokines is upregulated in differentiated myoblasts

muscle

abnormal skeletal muscle morphology ( J:214867 )

• skeletal muscle appears normal, however the slow twitch-muscle gene expression program is modified, with Il6, Glut4, and Rcan1 downregulated in soleus muscle, indicating that slow muscle fibers are transcripitionally adapted to fiber-type switching toward a faster phenotype

cardiovascular system

cardiovascular system phenotype ( J:215212 )

N	• mice have normal cardiac morphology and physiology

mortality/aging

mortality/aging ( J:215212 )

N	• mice are born at expected Mendelian ratios, are fertile, and survive until adulthood

Allelic Composition	Ankrd1^tm1Krc/Ankrd1^tm1Krc Ankrd2^tm1Krc/Ankrd2^tm1Krc Ankrd23^tm1Krc/Ankrd23^tm1Krc
Genetic Background	involves: 129 * Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ankrd1^tm1Krc mutation (0 available); any Ankrd1 mutation (20 available)
Ankrd23^tm1Krc mutation (0 available); any Ankrd23 mutation (6 available)
Ankrd2^tm1Krc mutation (0 available); any Ankrd2 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

abnormal sarcomere morphology ( J:125819 )

• sarcomere length at resting is longer than in wild-type mice

• titin lengths in the sarcomere are longer than in wild-type mice

abnormal muscle physiology ( J:125819 )

• muscles exhibit a greater degree of torque loss after eccentric contraction compared to wild-type mice

• however, muscle recovery is normal

cardiovascular system

cardiovascular system phenotype ( J:215212 )

N	• mice exhibit normal cardiac morphology and function and a normal hypertrophic response to transverse aortic constriction

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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