Analysis Tools
mortality/aging
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• mice die at birth without taking a breath
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nervous system
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• peripheral nerves are thin
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• axons from the dorsal thalamus extend beyond their nuclei, avoiding the telencephalon and extending along the diencephalons-telecephalon boundary
• however, at E13.5 a well-formed domain of Islet1+ cells is present in the subcortical telencephalon indicating that the permissive corridor for migration into the telencephalon is present
• descending axons extend through the cerebral white matter and terminate abruptly at the border between the cortex and the striatum
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• mice exhibit a general reduction in neurofilaments in the hippocampus, cerebral cortex, subcortical telencephalon and thalamus
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• mice exhibit a reduction in staining for neurites of GABAnergic interneurons without a reduction in the number of GABAnergic cell bodies in the cerebral cortex
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• the volume of lateral ventricles is increased and extends into the olfactory bulb
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• the corpus callosum is reduced in size in the anterior-posterior and dorsal-ventral axes
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• unlike in wild-type mice, corticofugal projections in the internal capsule contribute to the internal capsule
• mice lack the axonal tracts running through the internal capsule
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• the interpeduncular fossa is exaggerated
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• the diencephalon is small and altered in organization
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• the habenulopeduncular tract is short
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• the thalamus lacks innervation
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• the lateral geniculate nucleus lacks innervation
• however, axons leave the retina, form an optic nerve and reach and cross the optic chiasm
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• hippocampal formations are reduced in size and dysmorphic compared to in wild-type mice
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• corticofugal and thalamocortical projections are lost
• by E18.5, corticofugal axons fail to exit the cerebral cortex and the thamamocortical axons fail to reach their targets in the cortex
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• the thalamus lacks innervation
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• motor neurons terminate normally but also extend dysmorphic extrasynaptic variscosities filled with axonal and synaptic markers
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• the average motor unit size is increased relative to in wild-type mice with each motorneuron innervating more endplates than in wild-type mice
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• mice have narrow phrenic nerves with fewer axons than in wild-type mice
• the ventral most region of the diaphragm often lacks innervation
• although post-synaptic endplate numbers in the diaphragm are normal, endplates are more densely packed within a narrower endplate band
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muscle
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• the ventral most region of the diaphragm often lacks innervation
• although post-synaptic endplate numbers in the diaphragm are normal, endplates are more densely packed within a narrower endplate band
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cellular
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• axons from the dorsal thalamus extend beyond their nuclei, avoiding the telencephalon and extending along the diencephalons-telecephalon boundary
• however, at E13.5 a well-formed domain of Islet1+ cells is present in the subcortical telencephalon indicating that the permissive corridor for migration into the telencephalon is present
• descending axons extend through the cerebral white matter and terminate abruptly at the border between the cortex and the striatum
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