Analysis Tools
renal/urinary system
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• decrease in proximal tubule numbers at P0
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Allele Symbol Allele Name Allele ID |
Wasltm2Sbs targeted mutation 2, Scott B Snapper MGI:3760279 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Hypoplasia and loss of glomeruli and proximal tubules in Wasltm2Sbs/Wasltm2Sbs Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+ kidneys
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• decrease in proximal tubule numbers at P0
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• most mice develop signs of colitis by 2 months of age with elongation of crypts and mucosal thickening
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• unlike wild-type thymocytes, single positive (SP) thymocytes fail to proliferate after CD3 stimulation
• spreading of TCRhigh CD4 or CD8 SP thymocytes on a surface covered with antibodies to CD3 and CD28 is reduced
• migratory responses to CCL19 or CXCL12 are reduced even more than in Wastm1Sbs homozygotes and compared to in wild-type cells
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• mice exhibit a reduction in large and cycling double negative 3 (DN3) cells and, to a lesser degree, DN4 cells
• the ratio of DN3 to DN4 is skewed (3.18+/-1.89 compared to 0.74+/-0.45 in wild-type mice and 1.49+/-0.90 in Wastm1Sbs homozygotes)
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• the percent of double positive (DP) CD69hi cells is greater than in wild-type
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• the numbers of CD4+ and CD8+ T lymphocytes is reduced
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• the number of thymocytes is reduced
• however, there is no increase in apoptosis
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• mice have fewer single positive CD69hi cells compared to in wild-type mice and Wastm1Sbs homozygotes
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• the number of single positive CD69low CD62Llow cells is increased compared to in wild-type mice
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• unlike wild-type thymocytes, single positive (SP) thymocytes fail to proliferate after CD3 stimulation
• spreading of TCRhigh CD4 or CD8 SP thymocytes on a surface covered with antibodies to CD3 and CD28 is reduced
• migratory responses to CCL19 or CXCL12 are reduced even more than in Wastm1Sbs homozygotes and compared to in wild-type cells
|
|
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• mice exhibit a reduction in large and cycling double negative 3 (DN3) cells and, to a lesser degree, DN4 cells
• the ratio of DN3 to DN4 is skewed (3.18+/-1.89 compared to 0.74+/-0.45 in wild-type mice and 1.49+/-0.90 in Wastm1Sbs homozygotes)
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• the percent of double positive (DP) CD69hi cells is greater than in wild-type
|
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• the numbers of CD4+ and CD8+ T lymphocytes is reduced
|
|
|
• the number of thymocytes is reduced
• however, there is no increase in apoptosis
|
|
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• mice have fewer single positive CD69hi cells compared to in wild-type mice and Wastm1Sbs homozygotes
|
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• the number of single positive CD69low CD62Llow cells is increased compared to in wild-type mice
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• most mice develop signs of colitis by 2 months of age with elongation of crypts and mucosal thickening
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• most mice develop signs of colitis by 2 months of age with elongation of crypts and mucosal thickening
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• most mice develop signs of colitis by 2 months of age with elongation of crypts and mucosal thickening
|
|
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• the number of thymocytes is reduced
• however, there is no increase in apoptosis
|
|
|
• unlike wild-type thymocytes, single positive (SP) thymocytes fail to proliferate after CD3 stimulation
• spreading of TCRhigh CD4 or CD8 SP thymocytes on a surface covered with antibodies to CD3 and CD28 is reduced
• migratory responses to CCL19 or CXCL12 are reduced even more than in Wastm1Sbs homozygotes and compared to in wild-type cells
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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