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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Magel2tm1Stw
targeted mutation 1, Colin L Stewart
MGI:3760092
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Magel2tm1Stw/Magel2tm1Stw C57BL/6-Magel2tm1Stw MGI:3760114
hm2
Magel2tm1Stw/Magel2tm1Stw C57BL/6-Magel2tm1Stw/J MGI:5781308
ht3
Magel2tm1Stw/Magel2+ C57BL/6-Magel2tm1Stw MGI:3834842


Genotype
MGI:3760114
hm1
Allelic
Composition
Magel2tm1Stw/Magel2tm1Stw
Genetic
Background
C57BL/6-Magel2tm1Stw
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Magel2tm1Stw mutation (1 available); any Magel2 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• when the Magel2tm1Stw allele is inherited paternally, 10% fewer mice survive to weaning than expected

reproductive system
• when the Magel2tm1Stw allele is inherited paternally, males reproduce but with decreasing frequency and cease mating by 16 weeks unlike wild-type mice
• however, no defects in spermatogenesis and testes weight are observed

behavior/neurological
• when the Magel2tm1Stw allele is inherited paternally, mice run significantly less than wild-type mice (3047+/-930 counts per day compared to 12770+/-2343 counts per day for wild-type mice)
• when the Magel2tm1Stw allele is inherited paternally, mice run in more frequent and shorter bouts (8.5+/-0.7 bouts per day compared to 4.9+/-0.4 bouts per day for wild-type mice and 21.8+/-4.3 minutes per bout compared to 83.1+/-15.4 minutes per bout for wild-type mice)
• when the Magel2tm1Stw allele is inherited paternally, mice exhibit less daily activity during the subjective night (76.9+/-2.8% compared to 86.6+/-2.5% for wild-type mice)when the Magel2tm1Stw allele is inherited paternally, mice exhibit less daily activity during the subjective night (76.9+/-2.8% compared to 86.6+/-2.5% for wild-type mice)
• when the Magel2tm1Stw allele is inherited paternally, rhythms have lower chi-squared periodogram amplitudes than in wild-type mice
• when the Magel2tm1Stw allele is inherited paternally, after 24 hours starvation mice consume less food than wild-type mice
• when the Magel2tm1Stw allele is inherited paternally, mice run significantly less than wild-type mice (3047+/-930 counts per day compared to 12770+/-2343 counts per day for wild-type mice)
• when the Magel2tm1Stw allele is inherited paternally, mice run in more frequent and shorter bouts (8.5+/-0.7 bouts per day compared to 4.9+/-0.4 bouts per day for wild-type mice and 21.8+/-4.3 minutes per bout compared to 83.1+/-15.4 minutes per bout for wild-type mice)

growth/size/body
N
• when the Magel2tm1Stw allele is inherited paternally, surviving mice display no abnormalities in size or weight up to 2 years of age

cellular
• only the paternally inherited allele is expressed




Genotype
MGI:5781308
hm2
Allelic
Composition
Magel2tm1Stw/Magel2tm1Stw
Genetic
Background
C57BL/6-Magel2tm1Stw/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Magel2tm1Stw mutation (1 available); any Magel2 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue

behavior/neurological
• hindlimb and forelimb grip strength is less than controls and declines with age
• less vertical activity in light (42%) and dark (55%) cycles as compared to controls
• total distance travelled on progressive treadmill test is decreased as compared to controls in female mice and older male mice, 14 week old male mice perform similar to controls

cellular
• altered autophagy in soleus muscle
• p62 levels in fed mice are higher than in fed controls, fasted levels are similar to control

growth/size/body
• both male and female mice are obese with more fat mass and less lean mass than controls
• body composition in females is more abnormal than in males and consists of 2.3 times more fat and 8% less lean mass than controls

mortality/aging
• increased prenatal mortality as compared to controls
• early failure to thrive is observed

muscle
• smaller muscle fibers in gastrocnemius
• fiber type redistribution is not observed
• larger muscle fibers in soleus as compared to control
• fiber type redistribution is not observed
• reduction of total limb muscle weight to 87-93% of controls
• all individual muscle groups (gastrocnemius-soleus-plantaris, quadriceps, and tibialis anterior) are lighter than controls

respiratory system
N
• respiratory deficiency is not observed in young mice (P2 and P18)

skeleton
• mild spinal curvature characterized by a upward rotation of the right aspect of skull and, in some mice, a right thoracic curve

Mouse Models of Human Disease
OMIM ID Ref(s)
Prader-Willi Syndrome; PWS 176270 J:233299




Genotype
MGI:3834842
ht3
Allelic
Composition
Magel2tm1Stw/Magel2+
Genetic
Background
C57BL/6-Magel2tm1Stw
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Magel2tm1Stw mutation (1 available); any Magel2 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Older Magel2tm1Stw/Magel2+ females that inherit the mutant allele paternally lack corpora lutea in the ovaries

mortality/aging
• only 50-60% of pups born to female mice that inherit the mutant allele paternally survive until weaning
• infertility occurs in both sexes by 24 weeks of age in mice that inherit the mutant allele paternally
• fertility rates are normal between 7-14 weeks of age, drops to about 20% at 19-24 weeks of age, with no litters are born after 24 weeks of age
• at younger ages, there is also a significant increase in the mean time between pairing and successful breeding (males: 9 days vs. 4 days for controls, females: 12 days vs. 4 days in controls)

cellular
• only the paternally inherited allele is expressed

reproductive system
• an absence of corpus lutea is noted in 10 of 14 female mice that are over 24 weeks of age and have inherited the mutant allele paternally
• infertility occurs in both sexes by 24 weeks of age in mice that inherit the mutant allele paternally
• fertility rates are normal between 7-14 weeks of age, drops to about 20% at 19-24 weeks of age, with no litters are born after 24 weeks of age
• at younger ages, there is also a significant increase in the mean time between pairing and successful breeding (males: 9 days vs. 4 days for controls, females: 12 days vs. 4 days in controls)
• in female mice inheriting the mutant allele paternally, vaginal opening is significantly delayed by 1.4 days
• in female mice inheriting the mutant allele paternally, the age of first estrus is delayed by 5.3 days
• only 25% of mice experience proestrus in female mice that are 26 weeks of age and have inherited the mutant allele paternally
• estrous cycle is prolonged and irregular in female mice that have inherited the mutant allele paternally
• a mean of 6.4 pups is born to female mice that inherit the mutant allele paternally compared to 7.8 pups for controls

taste/olfaction
• latency time to find buried food is more than twice that of controls for mice that are over 24 weeks of age and have inherited the mutant allele paternally
• fasted male mice that have inherited the mutant allele paternally only investigate a dried vanilla spot for 0.75 s compared to 6.7 s for controls
• sexually-experienced male mice that have inherited the mutant allele paternally show no preference for female soiled bedding unlike their wild-type controls

behavior/neurological
• female mice with paternal inheritance of the mutant allele frequently cannibalize their pups

endocrine/exocrine glands
• an absence of corpus lutea is noted in 10 of 14 female mice that are over 24 weeks of age and have inherited the mutant allele paternally

homeostasis/metabolism
• mean serum testosterone levels are significantly lower in male mice that inherit the mutant allele paternally (6.1 ng/ml versus 20.2 ng/ml in controls)

Mouse Models of Human Disease
OMIM ID Ref(s)
Prader-Willi Syndrome; PWS 176270 J:144836





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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory