Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il2tm1Hor mutation
(5 available);
any
Il2 mutation
(41 available)
Tg(Pgk1-HA)1.1Vbo mutation
(0 available)
Tg(Tcra/Tcrb)1Vbo mutation
(1 available)
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hematopoietic system
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• CD25-positive CD4 T cells were almost completely absent in the lymph nodes and spleen, indicating that IL2 is needed to maintain this regulatory T subset
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• in the thymus, there is a substantial increase in the frequency and absolute numbers of CD25-positive CD4 T cells that have the characteristics of regulatory T cells
• this phenotype is similar to mice that express the same transgenes but have the Il2 locus intact, indicating that IL2 is not needed to generate this regulatory T cell subset
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• in the thymus, CD25-positive CD4 T cells express high levels of Foxp3
• this phenotype in the thymus is similar to transgenic mice that have the Il2 locus intact, indicating that IL2 is not needed to generate this regulatory T cell subset
• only 0.5% of CD25-positive CD4 T cells in the lymph nodes and spleen express Foxp3 compared to 9% of these cells in transgenic mice with the Il2 locus intact
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immune system
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• CD25-positive CD4 T cells were almost completely absent in the lymph nodes and spleen, indicating that IL2 is needed to maintain this regulatory T subset
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• in the thymus, there is a substantial increase in the frequency and absolute numbers of CD25-positive CD4 T cells that have the characteristics of regulatory T cells
• this phenotype is similar to mice that express the same transgenes but have the Il2 locus intact, indicating that IL2 is not needed to generate this regulatory T cell subset
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• in the thymus, CD25-positive CD4 T cells express high levels of Foxp3
• this phenotype in the thymus is similar to transgenic mice that have the Il2 locus intact, indicating that IL2 is not needed to generate this regulatory T cell subset
• only 0.5% of CD25-positive CD4 T cells in the lymph nodes and spleen express Foxp3 compared to 9% of these cells in transgenic mice with the Il2 locus intact
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il2ratm1Dw mutation
(3 available);
any
Il2ra mutation
(51 available)
Tg(Pgk1-HA)1.1Vbo mutation
(0 available)
Tg(Tcra/Tcrb)1Vbo mutation
(1 available)
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immune system
|
|
• CD25-positive CD4 T cells were almost completely absent in the lymph nodes and spleen, indicating that IL2 signaling is needed to maintain this regulatory T subset
|
|
|
• the thymus, there is a substantial increase in the frequency and absolute numbers of CD25-positive CD4 T cells that have the characteristics of regulatory T cells
• this phenotype is similar to transgenic mice that have the Il2ra locus intact, indicating that IL2 signalling is not needed to generate this regulatory T cell subset
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• CD25-positive CD4 T cells from the thymus have a reduced capacity to suppress T cell proliferation in vitro
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hematopoietic system
|
|
• CD25-positive CD4 T cells were almost completely absent in the lymph nodes and spleen, indicating that IL2 signaling is needed to maintain this regulatory T subset
|
|
|
• the thymus, there is a substantial increase in the frequency and absolute numbers of CD25-positive CD4 T cells that have the characteristics of regulatory T cells
• this phenotype is similar to transgenic mice that have the Il2ra locus intact, indicating that IL2 signalling is not needed to generate this regulatory T cell subset
|
|
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• CD25-positive CD4 T cells from the thymus have a reduced capacity to suppress T cell proliferation in vitro
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Pgk1-HA)1.1Vbo mutation
(0 available)
Tg(Tcra/Tcrb)1Vbo mutation
(1 available)
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immune system
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• there is a substantial increase in the frequencies and absolute numbers of CD25-positive CD4 T cells both in the thymus and peripheral lymph nodes compared to mice that express only the TCR transgene
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• CD25-positive CD4 T cells from the thymus express higher levels of Foxp3 compared to mice that express only the TCR transgene
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hematopoietic system
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• there is a substantial increase in the frequencies and absolute numbers of CD25-positive CD4 T cells both in the thymus and peripheral lymph nodes compared to mice that express only the TCR transgene
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• CD25-positive CD4 T cells from the thymus express higher levels of Foxp3 compared to mice that express only the TCR transgene
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Pgk1-HA)1.1Vbo mutation
(0 available)
Tg(Tcra/Tcrb)1Vbo mutation
(1 available)
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hematopoietic system
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• the percentage of double-positive T cells is increased compared to mice with just the TCR transgene (71% vs 62%)
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• the percentage of CD4 T cells in the thymus is decreased compared to mice with just the TCR transgene (20% vs 31%)
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• 5% of CD4 T cells from lymph nodes are CD25-positive and suppress the proliferation of nave CD4 T cells to hemagglutinin antigen in both in vitro and in vivo assays
• 10% of CD4-positive CD8-negative T cells from the thymus express CD25 and suppress the in vitro proliferation of nave CD4 T cells to hemagglutinin antigen
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immune system
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• the percentage of double-positive T cells is increased compared to mice with just the TCR transgene (71% vs 62%)
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• the percentage of CD4 T cells in the thymus is decreased compared to mice with just the TCR transgene (20% vs 31%)
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• 5% of CD4 T cells from lymph nodes are CD25-positive and suppress the proliferation of nave CD4 T cells to hemagglutinin antigen in both in vitro and in vivo assays
• 10% of CD4-positive CD8-negative T cells from the thymus express CD25 and suppress the in vitro proliferation of nave CD4 T cells to hemagglutinin antigen
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Analysis Tools