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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
B3gat1tm1Tkaw
targeted mutation 1, Toshisuke Kawasaki
MGI:3759445
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
B3gat1tm1Tkaw/B3gat1tm1Tkaw B6.129P2-B3gat1tm1Tkaw MGI:3759446
hm2
B3gat1tm1Tkaw/B3gat1tm1Tkaw involves: 129P2/OlaHsd MGI:3849318
cx3
B3gat1tm1Tkaw/B3gat1tm1Tkaw
B3gat2tm1Shok/B3gat2tm1Shok
involves: 129P2/OlaHsd * C57BL/6 MGI:6115795


Genotype
MGI:3759446
hm1
Allelic
Composition
B3gat1tm1Tkaw/B3gat1tm1Tkaw
Genetic
Background
B6.129P2-B3gat1tm1Tkaw
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B3gat1tm1Tkaw mutation (0 available); any B3gat1 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• long term potentiation induced by high frequency stimulation is reduced (131.9+/-8.4% of baseline compared to 161.7+/-7.3% of baseline in wild-type mice)
• however, presynaptic function (basal synaptic transmission paired pulse facilitation and synaptic response to a pair of afferent fiber stimuli) is normal

behavior/neurological
• in a Morris water maze, mice take more time to the hidden platform compared to wild-type mice
• however, motor activity is normal
• in a water-filled T-maze task, mice exhibit increased latency to escape compared to wild-type mice




Genotype
MGI:3849318
hm2
Allelic
Composition
B3gat1tm1Tkaw/B3gat1tm1Tkaw
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B3gat1tm1Tkaw mutation (0 available); any B3gat1 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• mice perform normally on a rotarod and balance beam




Genotype
MGI:6115795
cx3
Allelic
Composition
B3gat1tm1Tkaw/B3gat1tm1Tkaw
B3gat2tm1Shok/B3gat2tm1Shok
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B3gat1tm1Tkaw mutation (0 available); any B3gat1 mutation (14 available)
B3gat2tm1Shok mutation (0 available); any B3gat2 mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• viable

reproductive system





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory