• mice exhibit normal theta burst and high frequency stimulation of long term potentiation (J:194557)

• when treated with tamoxifen the level of serum corticosterone is increased to 39+/-8 ng/ml when one copies of the transgene is present, 100+/-20 ng/ml when two copies of the transgene are present and 108+/-19 ng/ml when four copies of the transgene are present compared to 13+/-5 ng/ml in wild-type

• in tamoxifen-treated mice during a dark-light box and elevated plus-maze

• tamoxifen-treated mice exhibit fewer dystrophic neurite clusters and few isolated neurites with residual bodies compared with control mice expressing Tg(APPswe,PSEN1dE9)85Dbo

• tamoxifen-treated mice develop fewer plaques than control mice expressing Tg(APPswe,PSEN1dE9)85Dbo

• tamoxifen-treated mice develop fewer plaques than control mice expressing Tg(APPswe,PSEN1dE9)85Dbo

• at P28, mice treated with tamoxifen during neonatal development exhibit loss of Prox1 expression in most dentate gyrus cells and both mature and immature granule cell properties and intermingled dentate gyrus progenitors in the granular layer unlike control mice

• at P28, mossy cells are reduced in the hilus compared to in control mice

• at P28, mice treated with tamoxifen during neonatal development exhibit loss of Prox1 expression in most dentate gyrus cells and both mature and immature granule cell properties unlike control mice