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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Camk2a-cre/ERT2)2Gsc
transgene insertion 2, Gunther Schutz
MGI:3759305
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Nr3c1tm2Gsc/Nr3c1tm2Gsc
Tg(Camk2a-cre/ERT2)2Gsc/0
involves: 129P2/OlaHsd * FVB/N MGI:3759306
cn2
Gt(ROSA)26Sortm1(Crh)Jde/Gt(ROSA)26Sortm1(Crh)Jde
Tg(Camk2a-cre/ERT2)2Gsc/0
involves: 129S2/SvPas * C57BL/6J * FVB/N MGI:5294462
cn3
Prkcztm1.1Rlh/Prkcztm1.1Rlh
Tg(Camk2a-cre/ERT2)2Gsc/0
involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL MGI:5485250
cn4
Map2k4tm1Ctr/Map2k4tm1Ctr
Map2k7tm1Rjd/Map2k7tm1Rjd
Tg(APPswe,PSEN1dE9)85Dbo/0
Tg(Camk2a-cre/ERT2)2Gsc/0
involves: C3H * C57BL/6 * FVB/N MGI:5297909
cx5
Prox1tm1.1Fuma/Prox1tm1.1Fuma
Tg(Camk2a-cre/ERT2)2Gsc/0
involves: C57BL/6NCrlj * CBA/JNCrlj * FVB/N MGI:5438959


Genotype
MGI:3759306
cn1
Allelic
Composition
Nr3c1tm2Gsc/Nr3c1tm2Gsc
Tg(Camk2a-cre/ERT2)2Gsc/0
Genetic
Background
involves: 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr3c1tm2Gsc mutation (1 available); any Nr3c1 mutation (12 available)
Tg(Camk2a-cre/ERT2)2Gsc mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• when treated with tamoxifen the level of serum corticosterone is increased to 39+/-8 ng/ml when one copies of the transgene is present, 100+/-20 ng/ml when two copies of the transgene are present and 108+/-19 ng/ml when four copies of the transgene are present compared to 13+/-5 ng/ml in wild-type




Genotype
MGI:5294462
cn2
Allelic
Composition
Gt(ROSA)26Sortm1(Crh)Jde/Gt(ROSA)26Sortm1(Crh)Jde
Tg(Camk2a-cre/ERT2)2Gsc/0
Genetic
Background
involves: 129S2/SvPas * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Crh)Jde mutation (0 available); any Gt(ROSA)26Sor mutation (317 available)
Tg(Camk2a-cre/ERT2)2Gsc mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• in tamoxifen-treated mice during a dark-light box and elevated plus-maze




Genotype
MGI:5485250
cn3
Allelic
Composition
Prkcztm1.1Rlh/Prkcztm1.1Rlh
Tg(Camk2a-cre/ERT2)2Gsc/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkcztm1.1Rlh mutation (1 available); any Prkcz mutation (20 available)
Tg(Camk2a-cre/ERT2)2Gsc mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• mice exhibit normal theta burst and high frequency stimulation of long term potentiation




Genotype
MGI:5297909
cn4
Allelic
Composition
Map2k4tm1Ctr/Map2k4tm1Ctr
Map2k7tm1Rjd/Map2k7tm1Rjd
Tg(APPswe,PSEN1dE9)85Dbo/0
Tg(Camk2a-cre/ERT2)2Gsc/0
Genetic
Background
involves: C3H * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map2k4tm1Ctr mutation (0 available); any Map2k4 mutation (16 available)
Map2k7tm1Rjd mutation (0 available); any Map2k7 mutation (6 available)
Tg(APPswe,PSEN1dE9)85Dbo mutation (0 available)
Tg(Camk2a-cre/ERT2)2Gsc mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• tamoxifen-treated mice develop fewer plaques than control mice expressing Tg(APPswe,PSEN1dE9)85Dbo
• tamoxifen-treated mice exhibit fewer dystrophic neurite clusters and few isolated neurites with residual bodies compared with control mice expressing Tg(APPswe,PSEN1dE9)85Dbo

homeostasis/metabolism
• tamoxifen-treated mice develop fewer plaques than control mice expressing Tg(APPswe,PSEN1dE9)85Dbo




Genotype
MGI:5438959
cx5
Allelic
Composition
Prox1tm1.1Fuma/Prox1tm1.1Fuma
Tg(Camk2a-cre/ERT2)2Gsc/0
Genetic
Background
involves: C57BL/6NCrlj * CBA/JNCrlj * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prox1tm1.1Fuma mutation (0 available); any Prox1 mutation (15 available)
Tg(Camk2a-cre/ERT2)2Gsc mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• at P28, mice treated with tamoxifen during neonatal development exhibit loss of Prox1 expression in most dentate gyrus cells and both mature and immature granule cell properties and intermingled dentate gyrus progenitors in the granular layer unlike control mice
• at P28, mossy cells are reduced in the hilus compared to in control mice
• at P28, mice treated with tamoxifen during neonatal development exhibit loss of Prox1 expression in most dentate gyrus cells and both mature and immature granule cell properties unlike control mice





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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory