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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Nlgn3tm1Sud
targeted mutation 1, Thomas C Sudhof
MGI:3758949
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Nlgn3tm1Sud/Y
Tg(Drd1-cre)EY262Gsat/0
involves: 129S1/Sv * 129X1/SvJ * FVB/N MGI:5660866
cx2
Nlgn3tm1Sud/Y
Tg(Drd1-tdTomato)5Calak/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:5660860
ot3
Nlgn3tm1Sud/Y involves: 129S1/Sv * 129X1/SvJ MGI:5660859
ot4
Nlgn3tm1Sud/Y involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3758961


Genotype
MGI:5660866
cn1
Allelic
Composition
Nlgn3tm1Sud/Y
Tg(Drd1-cre)EY262Gsat/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlgn3tm1Sud mutation (1 available); any Nlgn3 mutation (16 available)
Tg(Drd1-cre)EY262Gsat mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice exhibit increased learning rate but similar initial coordination on the accelerating rotarod
• mice perform similarly to wild-type littermates on the first trial of an accelerating rotarod, however in the last several trials, mice exhibit enhanced performance, with increased time on the rotarod before falling off compared to wild-type mice, indicating enhanced formation of repetitive motor routine




Genotype
MGI:5660860
cx2
Allelic
Composition
Nlgn3tm1Sud/Y
Tg(Drd1-tdTomato)5Calak/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlgn3tm1Sud mutation (1 available); any Nlgn3 mutation (16 available)
Tg(Drd1-tdTomato)5Calak mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mice show a reduction of synaptic inhibition onto D1-dopamine receptor-expressing medium spiny neurons of the nucleus accumbens, with the miniature inhibitory postsynaptic current (mIPSC) frequency in the nucleus accumbens reduced by about 50%, whereas the mIPSC amplitude is unchanged
• however, no change in mIPSC frequency or amplitude is seen in D2-dopamine receptor-expressing medium spiny neurons and no change is seen in mIPSC frequency or amplitude in D1-dopamine receptor-expressing medium spiny neurons of the dorsal striatum




Genotype
MGI:5660859
ot3
Allelic
Composition
Nlgn3tm1Sud/Y
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlgn3tm1Sud mutation (1 available); any Nlgn3 mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice exhibit increased learning rate but similar initial coordination on the accelerating rotarod
• mice are hyperactive during open-field tests, showing increased total distance traveled and increased number of ambulatory episodes, however, no changes in movement velocity or in crossings through the center of the open field are seen
• mice show greater number of wall jumps
• mice perform similarly to wild-type littermates on the first trial of an accelerating rotarod, however in the last several trials, mice exhibit enhanced performance, with increased time on the rotarod before falling off compared to wild-type mice
• the time spent performing stereotypic movements is enhanced during spontaneous open-field activity
• mice show increased vigor of stereotypic movements, indicated by greater force variance during periods of low mobility
• mice exhibit an abnormal bias in the direction of rotation during locomotion

Mouse Models of Human Disease
OMIM ID Ref(s)
Autism, Susceptibility to, X-Linked 1; AUTSX1 300425 J:214636




Genotype
MGI:3758961
ot4
Allelic
Composition
Nlgn3tm1Sud/Y
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlgn3tm1Sud mutation (1 available); any Nlgn3 mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• inhibitory postsynaptic currents (IPSCs) frequency is increased by 50% relative to in wild-type mice
• IPSC in response to GABA puff is increased relative to in wild-type mice
• IPSC strength is increased by about 50% relative to in wild-type mice

behavior/neurological
• spatial learning behavior in a Morris water maze is enhanced
• mice exhibit an increase in ability to find hidden platform in a Morris water maze and a decrease in training days
• after training, mice cross to the precise location of the hidden platform almost twice as often as wild-type mice
• response to a novel caged adult is decreased compared to in wild-type mice
• mice spend less time interacting with other mice compared to wild-type mice
• however, locomotor activity, motor coordination, exploration of novel objects, and anxiety-related behaviors are normal and mice are capable of learning social interaction behaviors following repeated exposure to the same mouse

Mouse Models of Human Disease
OMIM ID Ref(s)
Autism, Susceptibility to, X-Linked 1; AUTSX1 300425 J:125344





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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory