nervous system
|
|
• inhibitory postsynaptic currents (IPSCs) frequency is increased by 50% relative to in wild-type mice
(J:125344)
• IPSC in response to GABA puff is increased relative to in wild-type mice
(J:125344)
• IPSC strength is increased by about 50% relative to in wild-type mice
(J:125344)
|
behavior/neurological
|
|
• spatial learning behavior in a Morris water maze is enhanced
(J:125344)
• mice exhibit an increase in ability to find hidden platform in a Morris water maze and a decrease in training days
(J:125344)
• after training, mice cross to the precise location of the hidden platform almost twice as often as wild-type mice
(J:125344)
|
|
|
• response to a novel caged adult is decreased compared to in wild-type mice
(J:125344)
• mice spend less time interacting with other mice compared to wild-type mice
(J:125344)
• however, locomotor activity, motor coordination, exploration of novel objects, and anxiety-related behaviors are normal and mice are capable of learning social interaction behaviors following repeated exposure to the same mouse
(J:125344)
|
Mouse Models of Human Disease |
OMIM ID | Ref(s) | |
| Autism, Susceptibility to, X-Linked 1; AUTSX1 | 300425 | J:125344 | |
