Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ripply2tm1.1Ysa mutation
(1 available);
any
Ripply2 mutation
(15 available)
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skeleton
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• mice exhibit rostralization of vertebrae compared with wild-type mice
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• mice exhibit partial pedicle of the neural arches and separated lamina unlike wild-type mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ripply2tm1.1Ysa mutation
(1 available);
any
Ripply2 mutation
(15 available)
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mortality/aging
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• homozygotes die shortly after birth
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embryo
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• at E17.5, embryos have not undergone normal somitogenesis and display no clear segmental borders
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growth/size/body
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• at E17.5, embryos have short trunks
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limbs/digits/tail
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• at E17.5, embryos have short tails
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skeleton
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• at E17.5, embryos lack components of the proximal ribs
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• at E17.5, embryos show fewer pedicles of the neural arches
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muscle
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• at E17.5, embryos have irregularly sized myotomes
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ripply1tm1.1Sjt mutation
(0 available);
any
Ripply1 mutation
(9 available)
Ripply2tm1.1Ysa mutation
(1 available);
any
Ripply2 mutation
(15 available)
|
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skeleton
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• mice exhibit rostralization of vertebrae compared with wild-type mice that is enhanced compared to in Ripply2tm1.1Ysa homozygotes
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• with fusion of the lamina in the vertebrae
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embryo
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• marker expression reveals rostralization of somites compared to in wild-type mice
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ripply1tm1.1Sjt mutation
(0 available);
any
Ripply1 mutation
(9 available)
Ripply2tm1.1Ysa mutation
(1 available);
any
Ripply2 mutation
(15 available)
|
|
|
skeleton
|
• mice exhibit rostralization of vertebrae compared with wild-type mice that is enhanced compared to in Ripply2tm1.1Ysa homozygotes
|
|
• with fusion of the lamina in the vertebrae
|
embryo
|
• marker expression reveals rostralization of somites compared to in wild-type mice
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lfngtm1Rjo mutation
(0 available);
any
Lfng mutation
(32 available)
Ripply2tm1.1Ysa mutation
(1 available);
any
Ripply2 mutation
(15 available)
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embryo
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• embryos show a more rostralized phenotype than Ripply2-null embryos
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skeleton
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• pedicals of the neural arches are almost completely absent
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