Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Omptm1(tTA)Gogo mutation
(1 available);
any
Omp mutation
(27 available)
Tg(tetO-Kcnj2,lacZ)1Gogo mutation
(1 available)
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nervous system
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• following doxycycline treatment, organization of the glomeruli in the dorsal part of the bulb remains disorganized, thinly innervated, necklace glomeruli are absent, and nerves that enter the bulb coalesce into a giant glomerulus-like structure
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• following doxycycline treatment, the spiking activity of olfactory nerves is inhibited
• following doxycycline treatment, the entry of the sensory neuron into the olfactory bulb is delayed
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Omptm1(tTA)Gogo mutation
(1 available);
any
Omp mutation
(27 available)
Or4e5tm2Rax mutation
(0 available);
any
Or4e5 mutation
(20 available)
Tg(tetO-Kcnj2,lacZ)1Gogo mutation
(1 available)
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nervous system
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• following doxycycline treatment, at P1 and more profoundly at P21 Olfr17+ olfactory nerves are diffusely distributed and 75% of those that enter the olfactory bulb innervate two to three glomeruli in the ventral portion of the bulb
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Omptm1(tTA)Gogo mutation
(1 available);
any
Omp mutation
(27 available)
Or10a4tm6Rax mutation
(0 available);
any
Or10a4 mutation
(22 available)
Tg(tetO-Kcnj2,lacZ)1Gogo mutation
(1 available)
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nervous system
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• following doxycycline treatment, at P1 and more profoundly at P21 Olfr17+ olfactory nerves are diffusely distributed and those that enter the olfactory bulb sparsely innervate an average of 16 glomeruli in the ventral portion of the bulb
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Or10a4tm5(rtTA)Rax mutation
(0 available);
any
Or10a4 mutation
(22 available)
Tg(tetO-Kcnj2,lacZ)1Gogo mutation
(1 available)
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nervous system
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• following doxycycline treatment during gestation, Oflr17+ olfactory nerve cells call to enter the olfactory bulb with only a few fibers crossing the cribriform plate that do not converge to form a single glomerulus but innervate a broad region o the ventral portion of the bulb
• following doxycycline treatment during gestation, the number of Oflr17+ olfactory nerves is decreased by 5-fold at P21
• after 40 days of doxycycline, Olfr17+ olfactory nerves no longer converge on a Oflr17+ glomerulus and few nerves stain positive for lacZ
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Analysis Tools