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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Thy1-BACE1)16Vln
transgene insertion 16, Fred Van Leuven
MGI:3722132
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Tg(Thy1-APPLon)2Vln/0
Tg(Thy1-BACE1)16Vln/0
involves: C57BL/6 * DBA * FVB/N MGI:3722143


Genotype
MGI:3722143
cx1
Allelic
Composition
Tg(Thy1-APPLon)2Vln/0
Tg(Thy1-BACE1)16Vln/0
Genetic
Background
involves: C57BL/6 * DBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• fibrillar thioflavin-S positive amyloid plaques are significantly increased in subiculum region of brain compared to Tg(APPV717I)1130Kha single transgenics
• decrease in vascular amyloid deposition is found in double transgenics relative to single mutant animals
• by 15 months, subiculum is almost totally covered with diffuse and senile plaques
• at 15 months and older, surface of cerebral cortex is occupied by thioflavin-S- and amyloid beta-positive deposits is 3-5-fold greater than in age-matched Tg(APPV717I)1130Kha mice
• dystrophic neurites with swollen and distorted neuritic profiles are identified in brains of mice

homeostasis/metabolism
• total levels of intact amyloid beta-40 and-42 peptides are increased by ~3-fold in older mice relative to single transgenic mice
• fibrillar thioflavin-S positive amyloid plaques are significantly increased in subiculum region of brain compared to Tg(APPV717I)1130Kha single transgenics
• decrease in vascular amyloid deposition is found in double transgenics relative to single mutant animals

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:93635





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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory