Mouse Genome Informatics
cx1
    Tg(Thy1-APPLon)2Vln/0
Tg(Thy1-BACE1)16Vln/0

involves: C57BL/6 * DBA * FVB/N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• by 15 months, subiculum is almost totally covered with diffuse and senile plaques
• at 15 months and older, surface of cerebral cortex is occupied by thioflavin-S- and amyloid beta-positive deposits is 3-5-fold greater than in age-matched Tg(APPV717I)1130Kha mice
• decrease in vascular amyloid deposition is found in double transgenics relative to single mutant animals
• dystrophic neurites with swollen and distorted neuritic profiles are identified in brains of mice
• fibrillar thioflavin-S positive amyloid plaques are significantly increased in subiculum region of brain compared to Tg(APPV717I)1130Kha single transgenics

other phenotype
• total levels of intact amyloid beta-40 and-42 peptides are increased by ~3-fold in older mice relative to single transgenic mice
• decrease in vascular amyloid deposition is found in double transgenics relative to single mutant animals
• fibrillar thioflavin-S positive amyloid plaques are significantly increased in subiculum region of brain compared to Tg(APPV717I)1130Kha single transgenics

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease; AD 104300 J:93635