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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(GSK3B*S9A)1Vln
transgene insertion 1, Fred Fan Leuven
MGI:3722095
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Tg(GSK3B*S9A)1Vln/0
Tg(Thy1-MAPT)1Vln/Tg(Thy1-MAPT)1Vln
involves: FVB MGI:3722101
cx2
Tg(GSK3B*S9A)1Vln/0
Tg(Thy1-MAPT)2Vln/Tg(Thy1-MAPT)2Vln
involves: FVB MGI:3722102


Genotype
MGI:3722101
cx1
Allelic
Composition
Tg(GSK3B*S9A)1Vln/0
Tg(Thy1-MAPT)1Vln/Tg(Thy1-MAPT)1Vln
Genetic
Background
involves: FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• mice show equal performance to wild-type in the hanging grid test and forced swim test, and show almost no impairment of the righting reflex
• double mutants are unable to remain on the rotating rod

nervous system
• in 3-month old mice, dilated axons are observed, but numbers are reduced ~5-fold in spinal cord and ~20-fold in cerebral cortex compared to Tg(Thy1-MAPT)1Vln homozygotes
• axonal dystrophic changes are dramatically reduced in mice expressing both transgenes

muscle
N
• quadriceps is normal and devoid of any muscle wasting

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:100971




Genotype
MGI:3722102
cx2
Allelic
Composition
Tg(GSK3B*S9A)1Vln/0
Tg(Thy1-MAPT)2Vln/Tg(Thy1-MAPT)2Vln
Genetic
Background
involves: FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• mice show equal performance to wild-type in the hanging grid test and forced swim test, and show almost no impairment of the righting reflex
• double mutants are unable to remain on the rotating rod

nervous system
• in 3-month old mice, dilated axons are observed, but numbers are reduced ~10-fold compared to Tg(Thy1-MAPT)2Vln homozygotes in spinal cord and cerebral cortex
• axonal dystrophic changes are dramatically reduced in mice expressing both transgenes

muscle
N
• quadriceps is normal and devoid of any muscle wasting

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:100971





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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory