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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Txnrd1tm1.1Ees
targeted mutation 1.1, Edward E Schmidt
MGI:3722092
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Txnrd1tm1.1Ees/Txnrd1tm1.1Ees B6.129X1-Txnrd1tm1.1Ees MGI:3722804


Genotype
MGI:3722804
hm1
Allelic
Composition
Txnrd1tm1.1Ees/Txnrd1tm1.1Ees
Genetic
Background
B6.129X1-Txnrd1tm1.1Ees
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Txnrd1tm1.1Ees mutation (0 available); any Txnrd1 mutation (39 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no embryos are recovered after E8.5 when mice are present in expected Mendelian ratios

embryo
• embryonic development is arrested at the pre-streak stage, mesoderm does not form, embryonic tissues are reduced, and patterning of embryonic tissues is either arrested or incorrect resulting in a failure to gastrulate
• at E8.5, embryos are three times the size they were at E7.5 and appear to be undifferentiated ectoderm, expanded into a highly organized structure
• at E7.5, embryonic ectoderm (epiblast) does not differentiate
• at E8.5, trophoblast giant cells are abundant
• at E7.5, visceral endoderm morphology resembles that of the extraembryonic region
• at E8.5, visceral endoderm with extraembryonic morphology is expanded, vacuolated and folded upon itself into a thick layer





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory