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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Ins2-cre)5Lt
transgene insertion 5, Edward Leiter
MGI:3721303
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(Ins2-cre)5Lt/Tg(Ins2-cre)5Lt NOD/ShiLt-Tg(Ins2-cre)5Lt MGI:3762923
tg2
Tg(Ins2-cre)5Lt/0 NOD/ShiLt-Tg(Ins2-cre)5Lt MGI:3762924


Genotype
MGI:3762923
tg1
Allelic
Composition
Tg(Ins2-cre)5Lt/Tg(Ins2-cre)5Lt
Genetic
Background
NOD/ShiLt-Tg(Ins2-cre)5Lt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Ins2-cre)5Lt mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• homozygotes are viable and live to >40 weeks, as do homozygotes of line 9 (not fully described) in contrast to lethality of homozygosity in lines 3 and 6

immune system
• widespread insulitis is recorded in many homozygous mice of both sexes at termination of study (40 weeks)
• homozygous mice show significant suppression of diabetes (~65% of females and ~85% of males are diabetes free >40 weeks, compared to ~25-30% of hemizygous animals (difference seen in hemizygotes likely due to gene dosage) or hemi- or homozygous mice of transgenic line 9

endocrine/exocrine glands
• widespread insulitis is recorded in many homozygous mice of both sexes at termination of study (40 weeks)




Genotype
MGI:3762924
tg2
Allelic
Composition
Tg(Ins2-cre)5Lt/0
Genetic
Background
NOD/ShiLt-Tg(Ins2-cre)5Lt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Ins2-cre)5Lt mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• <15% of male and female hemizygotes are diabetes free by ~32 weeks of age in contrast to homozygotes





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last database update
01/04/2022
MGI 6.17
The Jackson Laboratory