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Allele Symbol Allele Name Allele ID |
Zbtb17tm1Cksn targeted mutation 1, Christian Kosan MGI:3721142 |
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| Summary |
5 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• double negative to double positive differentiation is blocked unlike in wild-type mice
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• double negative to double positive differentiation is blocked unlike in wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• pro-T cells exhibit excessive cell death unlike wild-type cells
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• 100-fold reduction in cellularity
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• early lymphoid progenitors and early thymic precursors fail to differentiate into mature T cells in the presence of Il7 unlike in wild-type mice
• however, inhibition of SOCS1 or overexpression of Bcl2 restores T cell differentiation in vitro
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• alphabeta-T cells are reduced 1000-fold compared to in wild-type mice
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• early T-cell precursors in the thymus are reduced compared to in wild-type mice
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• DN1a-e subsets are decreased 70- to 130-fold compared to in wild-type mice
• DN1a/b cells are decreased 230-fold compared to in wild-type mice
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• 100-fold reduction in DN2a cells
• 40-fold reduction in DN2b cells
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• 3-fold reduction in DN3a cells
• 10-fold reduction in DN3b cells
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• 7-fold
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• pro-T cells exhibit excessive cell death unlike wild-type cells
|
|
• 100-fold reduction in cellularity
|
|
• early lymphoid progenitors and early thymic precursors fail to differentiate into mature T cells in the presence of Il7 unlike in wild-type mice
• however, inhibition of SOCS1 or overexpression of Bcl2 restores T cell differentiation in vitro
|
|
• alphabeta-T cells are reduced 1000-fold compared to in wild-type mice
|
|
• early T-cell precursors in the thymus are reduced compared to in wild-type mice
|
|
• DN1a-e subsets are decreased 70- to 130-fold compared to in wild-type mice
• DN1a/b cells are decreased 230-fold compared to in wild-type mice
|
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• 100-fold reduction in DN2a cells
• 40-fold reduction in DN2b cells
|
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• 3-fold reduction in DN3a cells
• 10-fold reduction in DN3b cells
|
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• 7-fold
|
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• pro-T cells exhibit excessive cell death unlike wild-type cells
|
|
• 100-fold reduction in cellularity
|
|
• early T-cell precursors in the thymus are reduced compared to in wild-type mice
|
|
• DN1a-e subsets are decreased 70- to 130-fold compared to in wild-type mice
• DN1a/b cells are decreased 230-fold compared to in wild-type mice
|
|
• 100-fold reduction in DN2a cells
• 40-fold reduction in DN2b cells
|
|
• 3-fold reduction in DN3a cells
• 10-fold reduction in DN3b cells
|
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit normal thymic cellularity and development
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at one year of age mice have darker coat and skin than wild-type mice
• in areas of substantial hair loss a black dot-like area is visible
• light-tipped zigzag hairs are decreased in number
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• back skin displays abnormal content distribution of melanin
• in areas of substantial hair loss a black dot-like area is visible
• mice exhibit focal areas in the dermis and subcutis around hair follicles with high melanin content
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• keratinocyte located at the orifice of the hair funnel exhibit increased proliferation
• proliferation of keratinocyte in the anagen but not the catagen of the hair cycle is increased
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• at one year of age mice have darker coat and skin than wild-type mice
• in areas of substantial hair loss a black dot-like area is visible
• light-tipped zigzag hairs are decreased in number
|
|
• back skin displays abnormal content distribution of melanin
• in areas of substantial hair loss a black dot-like area is visible
• mice exhibit focal areas in the dermis and subcutis around hair follicles with high melanin content
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• mice experience hair loss on the back skin without a reduction in the number of hair follicles
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• hair density is decreased
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• 100% of mice have rough fur
• initially rough areas appear in stripes
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• only 24% to 54% of hairs are of the zigzag type compared to 70% in wild-type mice
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• hair follicle length is highly variable relative to in wild-type mice
• cyst-like hair follicles containing hair remnants are observed in some areas
• cystic alterations occur in the upper part of the follicle and epithelium of the cyst-like structure is continuous with the epidermis
• the number of hair follicles extending into the subcutis is increased relative to in wild-type mice
• catagen during the hair cycle is delayed
• at one year of age, numerous back skin hair follicles are thickened
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• the orientation of hair follicles is altered relative to in wild-type mice
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• the number of interfollicular epidermal layers is increased
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• keratinocyte located at the orifice of the hair funnel exhibit increased proliferation
• proliferation of keratinocyte in the anagen but not the catagen of the hair cycle is increased
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 100% of mice have rough fur
• initially rough areas appear in stripes
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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