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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Zbtb17tm1Cksn
targeted mutation 1, Christian Kosan
MGI:3721142
Summary 5 genotypes


Genotype
MGI:5006710
cn1
Allelic
Composition
Cdkn1atm1Led/Cdkn1atm1Led
Zbtb17tm1Cksn/Zbtb17tm1Cksn
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
B6.Cg-Zbtb17tm1Cksn Cdkn1atm1Led Commd10Tg(Vav1-icre)A2Kio
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn1atm1Led mutation (1 available); any Cdkn1a mutation (51 available)
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (8 available)
Zbtb17tm1Cksn mutation (1 available); any Zbtb17 mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• double negative to double positive differentiation is blocked unlike in wild-type mice

hematopoietic system
• double negative to double positive differentiation is blocked unlike in wild-type mice




Genotype
MGI:5006709
cn2
Allelic
Composition
Zbtb17tm1Cksn/Zbtb17tm1Cksn
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
B6.Cg-Zbtb17tm1Cksn Commd10Tg(Vav1-icre)A2Kio
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (8 available)
Zbtb17tm1Cksn mutation (1 available); any Zbtb17 mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• pro-T cells exhibit excessive cell death unlike wild-type cells
• 100-fold reduction in cellularity
• early lymphoid progenitors and early thymic precursors fail to differentiate into mature T cells in the presence of Il7 unlike in wild-type mice
• however, inhibition of SOCS1 or overexpression of Bcl2 restores T cell differentiation in vitro
• alphabeta-T cells are reduced 1000-fold compared to in wild-type mice
• early T-cell precursors in the thymus are reduced compared to in wild-type mice
• DN1a-e subsets are decreased 70- to 130-fold compared to in wild-type mice
• DN1a/b cells are decreased 230-fold compared to in wild-type mice
• 100-fold reduction in DN2a cells
• 40-fold reduction in DN2b cells
• 3-fold reduction in DN3a cells
• 10-fold reduction in DN3b cells

hematopoietic system
• pro-T cells exhibit excessive cell death unlike wild-type cells
• 100-fold reduction in cellularity
• early lymphoid progenitors and early thymic precursors fail to differentiate into mature T cells in the presence of Il7 unlike in wild-type mice
• however, inhibition of SOCS1 or overexpression of Bcl2 restores T cell differentiation in vitro
• alphabeta-T cells are reduced 1000-fold compared to in wild-type mice
• early T-cell precursors in the thymus are reduced compared to in wild-type mice
• DN1a-e subsets are decreased 70- to 130-fold compared to in wild-type mice
• DN1a/b cells are decreased 230-fold compared to in wild-type mice
• 100-fold reduction in DN2a cells
• 40-fold reduction in DN2b cells
• 3-fold reduction in DN3a cells
• 10-fold reduction in DN3b cells

cellular
• pro-T cells exhibit excessive cell death unlike wild-type cells

endocrine/exocrine glands
• 100-fold reduction in cellularity
• early T-cell precursors in the thymus are reduced compared to in wild-type mice
• DN1a-e subsets are decreased 70- to 130-fold compared to in wild-type mice
• DN1a/b cells are decreased 230-fold compared to in wild-type mice
• 100-fold reduction in DN2a cells
• 40-fold reduction in DN2b cells
• 3-fold reduction in DN3a cells
• 10-fold reduction in DN3b cells




Genotype
MGI:5006711
cn3
Allelic
Composition
Zbtb17tm1Cksn/Zbtb17tm1Cksn
Tg(Lck-cre)548Jxm/0
Genetic
Background
B6.Cg-Zbtb17tm1Cksn Tg(Lck-cre)548Jxm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Lck-cre)548Jxm mutation (2 available)
Zbtb17tm1Cksn mutation (1 available); any Zbtb17 mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• mice exhibit normal thymic cellularity and development




Genotype
MGI:3721959
cn4
Allelic
Composition
Zbtb17tm1Cksn/Zbtb17tm1Cksn
Krt14tm1(cre)Wbm/Krt14+
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krt14tm1(cre)Wbm mutation (0 available); any Krt14 mutation (6 available)
Zbtb17tm1Cksn mutation (1 available); any Zbtb17 mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• at one year of age mice have darker coat and skin than wild-type mice
• in areas of substantial hair loss a black dot-like area is visible
• light-tipped zigzag hairs are decreased in number
• back skin displays abnormal content distribution of melanin
• in areas of substantial hair loss a black dot-like area is visible
• mice exhibit focal areas in the dermis and subcutis around hair follicles with high melanin content

integument
• keratinocyte located at the orifice of the hair funnel exhibit increased proliferation
• proliferation of keratinocyte in the anagen but not the catagen of the hair cycle is increased
• at one year of age mice have darker coat and skin than wild-type mice
• in areas of substantial hair loss a black dot-like area is visible
• light-tipped zigzag hairs are decreased in number
• back skin displays abnormal content distribution of melanin
• in areas of substantial hair loss a black dot-like area is visible
• mice exhibit focal areas in the dermis and subcutis around hair follicles with high melanin content
• mice experience hair loss on the back skin without a reduction in the number of hair follicles
• hair density is decreased
• 100% of mice have rough fur
• initially rough areas appear in stripes
• only 24% to 54% of hairs are of the zigzag type compared to 70% in wild-type mice
• hair follicle length is highly variable relative to in wild-type mice
• cyst-like hair follicles containing hair remnants are observed in some areas
• cystic alterations occur in the upper part of the follicle and epithelium of the cyst-like structure is continuous with the epidermis
• the number of hair follicles extending into the subcutis is increased relative to in wild-type mice
• catagen during the hair cycle is delayed
• at one year of age, numerous back skin hair follicles are thickened
• the orientation of hair follicles is altered relative to in wild-type mice
• the number of interfollicular epidermal layers is increased

cellular
• keratinocyte located at the orifice of the hair funnel exhibit increased proliferation
• proliferation of keratinocyte in the anagen but not the catagen of the hair cycle is increased




Genotype
MGI:3721960
cn5
Allelic
Composition
Zbtb17tm1Cksn/Zbtb17tm1.1Cksn
Krt14tm1(cre)Wbm/Krt14+
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krt14tm1(cre)Wbm mutation (0 available); any Krt14 mutation (6 available)
Zbtb17tm1.1Cksn mutation (0 available); any Zbtb17 mutation (6 available)
Zbtb17tm1Cksn mutation (1 available); any Zbtb17 mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• 100% of mice have rough fur
• initially rough areas appear in stripes





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory