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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Siglec1tm1(HBEGF)Mtka
targeted mutation 1, Masato Tanaka
MGI:3720841
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Siglec1tm1(HBEGF)Mtka/Siglec1tm1(HBEGF)Mtka
1700016L21RikTg(Itgax-HBEGF/EGFP)57Lan/? 		involves: 129S1/Sv * 129X1/SvJ * FVB/N MGI:3721136


Genotype
MGI:3721136
cx1
Allelic
Composition		 Siglec1tm1(HBEGF)Mtka/Siglec1tm1(HBEGF)Mtka
1700016L21RikTg(Itgax-HBEGF/EGFP)57Lan/?
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
1700016L21RikTg(Itgax-HBEGF/EGFP)57Lan mutation (6 available); any 1700016L21Rik mutation (4 available)
Siglec1tm1(HBEGF)Mtka mutation (2 available); any Siglec1 mutation (82 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal metallophilic macrophage morphology ( J:123958 )
• following diptheria toxin (DT) treatment, metallophilic macrophages and marginal zone macrophages are absent
abnormal spleen marginal zone macrophage morphology ( J:123958 )
• following diptheria toxin (DT) treatment, metallophilic macrophages and marginal zone macrophages are absent
abnormal macrophage physiology ( J:123958 )
• following diptheria toxin (DT) treatment, clearance of injected apoptotic cells injected into the spleen is delayed
abnormal dendritic cell physiology ( J:123958 )
• following diptheria toxin (DT) treatment, more Itgax+ dendritic cells phagocytose apoptotic cells than in wild-type mice
• following diptheria toxin (DT) treatment, the antigen presenting ability of Itgax+ dendritic cells is increased relative to in wild-type mice
abnormal immune tolerance ( J:123958 )
• following diptheria toxin (DT) treatment, induction of tolerance fails

hematopoietic system
abnormal metallophilic macrophage morphology ( J:123958 )
• following diptheria toxin (DT) treatment, metallophilic macrophages and marginal zone macrophages are absent
abnormal spleen marginal zone macrophage morphology ( J:123958 )
• following diptheria toxin (DT) treatment, metallophilic macrophages and marginal zone macrophages are absent
abnormal macrophage physiology ( J:123958 )
• following diptheria toxin (DT) treatment, clearance of injected apoptotic cells injected into the spleen is delayed




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory