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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Itgax-cre,-EGFP)4097Ach
transgene insertion 4097, Alexander V Chervonsky
MGI:3720729
Summary 5 genotypes


Genotype
MGI:5558060
cn1
Allelic
Composition
Ifngr1tm1.1Rds/Ifngr1tm1.1Rds
Tg(Itgax-cre,-EGFP)4097Ach/0
Genetic
Background
B6NTac.Cg-Ifngr1tm1.1Rds Tg(Itgax-cre,-EGFP)4097Ach
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifngr1tm1.1Rds mutation (1 available); any Ifngr1 mutation (34 available)
Tg(Itgax-cre,-EGFP)4097Ach mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

immune system
• from NK and NK T cells of mice infected with L. monocytogenes
• however, production in CD8+ T cells is normal
• reduced from CD8a+ dendritic cells of mice infected with L. monocytogenes
• production from Ly6c+ monocytes is temporarily delayed
• mice infected with L. monocytogenes exhibit increased mortality, spleen and liver bacterial counts, reduced IL12b production from CD8a+ dendritic cells compared with control mice
• intravenous L. monocytogenes infection results in reduced bacterial burden
• however, treatment with IL4 neutralizing antibody reduces bacterial burden




Genotype
MGI:5318548
cn2
Allelic
Composition
Cd1d1tm1.1Aben/Cd1d1tm1.1Aben
Tg(Itgax-cre,-EGFP)4097Ach/0
Genetic
Background
C57BL/6-Cd1d1tm1.1Aben Tg(Itgax-cre,-EGFP)4097Ach
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd1d1tm1.1Aben mutation (1 available); any Cd1d1 mutation (7 available)
Tg(Itgax-cre,-EGFP)4097Ach mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• mice exhibit normal development and distribution of NK T cells
• decreased in splenic and liver NK T cells after injection of alphaGC
• absent in splenic and liver NK cells after injection of alphaGC
• decreased in splenic and liver NK T cells after injection of alphaGC




Genotype
MGI:5451018
cn3
Allelic
Composition
Abca1tm1Jp/Abca1tm1Jp
Abcg1tm1Tall/Abcg1tm1Tall
Tg(Itgax-cre,-EGFP)4097Ach/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abca1tm1Jp mutation (2 available); any Abca1 mutation (56 available)
Abcg1tm1Tall mutation (1 available); any Abcg1 mutation (15 available)
Tg(Itgax-cre,-EGFP)4097Ach mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• mice exhibit an increase in colony-forming units in the blood

immune system
• 1.8-fold in the spleen




Genotype
MGI:5751549
cn4
Allelic
Composition
Tlr5tm1.1Gewr/Tlr5tm1.1Gewr
Tg(Itgax-cre,-EGFP)4097Ach/?
Genetic
Background
involves: C57BL/6J * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Itgax-cre,-EGFP)4097Ach mutation (2 available)
Tlr5tm1.1Gewr mutation (1 available); any Tlr5 mutation (43 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue

digestive/alimentary system
• delayed clearance of pathobiont bacteria
• decreased distance of fecal bacteria from intestinal epithelial cells

immune system
N
• mice do not exhibit spontaneous colitis, low grade inflammation or metabolic syndrome




Genotype
MGI:3720730
cn5
Allelic
Composition
Fastm1Ach/Fastm1Ach
Tg(Itgax-cre,-EGFP)4097Ach/?
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fastm1Ach mutation (0 available); any Fas mutation (48 available)
Tg(Itgax-cre,-EGFP)4097Ach mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• dendritic cell number increases with age in the spleen
• mice exhibit histological changes in the spleen
• loss of follicular architecture is associated with splenomegaly
• splenomegaly is associated with loss of follicular architecture
• dendritic cells are spread throughout the periarteriolar lymphoid sheath
• mice have hyperimmunoglobulinemia
• elevation in anti-nuclear antibodies occurs as early as 8 weeks in some mice and by 12 to 16 weeks in most mice

liver/biliary system
• mice exhibit histological changes in the liver
• polymorphic infiltrate, including Itgax+ dendritic cells and various
• leukocytes, is found around central veins in the liver

cellular
• bone marrow dendritic cells are resistant to apoptosis following stimulation with LPS and exposure to CT26 carcinoma cells transfected with human FasL
• splenic dendritic cells are resistant to apoptosis in vivo initiated by cognate OT-1 T cells

hematopoietic system
• dendritic cell number increases with age in the spleen
• mice exhibit histological changes in the spleen
• loss of follicular architecture is associated with splenomegaly
• splenomegaly is associated with loss of follicular architecture
• dendritic cells are spread throughout the periarteriolar lymphoid sheath
• mice have hyperimmunoglobulinemia





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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory