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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(DMD-APP*)18Neve
transgene insertion 18, Rachel L Neve
MGI:3720650
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(DMD-APP*)18Neve/0 involves: C57BL/6 * SJL MGI:3720677


Genotype
MGI:3720677
tg1
Allelic
Composition
Tg(DMD-APP*)18Neve/0
Genetic
Background
involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• greatly increased numbers of microglial cells containing phagocytic debris are seen in the hippocampus of 12-month old mice

immune system
• greatly increased numbers of microglial cells containing phagocytic debris are seen in the hippocampus of 12-month old mice

nervous system
• greatly increased numbers of microglial cells containing phagocytic debris are seen in the hippocampus of 12-month old mice
• hippocampi contain numerous degenerating pyramidal and granule cells
• synaptic degeneration is evident throughout the hippocampi of 12-month old animals
• in ~1 year-old mice, numerous large lucent pyramidal neurons containing irregular cytoplasmic accumulations of atypical secondary lysosomes are observed, with comparable severity to ~2-year old Tg(DMD-APP*)7Neve mice
• mice show comparable degeneration at an earlier age (~1 year) than Tg(DMD-APP*)7Neve mice

homeostasis/metabolism
• hippocampi contain numerous degenerating pyramidal and granule cells

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:100978





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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory