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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Il4ratm2Tch
targeted mutation 2, Talal A Chatila
MGI:3720593
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Il4ratm2Tch/Il4ratm2Tch C.129X1-Il4ratm2Tch MGI:4361938
cx2
Il4ratm2Tch/Il4ratm2Tch
Tg(Scgb1a1-rtTA,tetO-Il13)1Eli/?
B6.Cg-Il4ratm2Tch Tg(Scgb1a1-rtTA,tetO-IL13)1Eli MGI:4361939


Genotype
MGI:4361938
hm1
Allelic
Composition
Il4ratm2Tch/Il4ratm2Tch
Genetic
Background
C.129X1-Il4ratm2Tch
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il4ratm2Tch mutation (1 available); any Il4ra mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
respiratory system
• mutant mice exhibit airway inflammation following chronic allergen challenge
• increase in peribronchial and perivascular inflammation compared with control
• OVA sensitized and challenged mutant (R576) mice exhibit patchy peribronchial inflammatory infiltrate that is more prominent that in Q576 controls
• peribronchial infiltrate is composed primarily of eosinophils and lymphoctyes
• OVA or IL13 challenged mice exhibit goblet cell hyperplasia
• enhanced response to IL13 challenge

immune system
• increase in eosinophils found in lung parenchyma of OVA sensitized mutant mice
• increase in monocytes found in lung parenchyma of OVA sensitized mutant mice
• following immunization with OVA or alum
• stimulated Th2 cells exhibit an increase in IL4 production, but not IL5 or IL13
• stimulated Th2 cells exhibit an increase in IL4 production
• enhanced allergic inflammatory response following IL13 challenge
• mutant mice exhibit airway inflammation following chronic allergen challenge
• increase in peribronchial and perivascular inflammation compared with control

hematopoietic system
• increase in eosinophils found in lung parenchyma of OVA sensitized mutant mice
• increase in monocytes found in lung parenchyma of OVA sensitized mutant mice
• following immunization with OVA or alum
• stimulated Th2 cells exhibit an increase in IL4 production, but not IL5 or IL13

homeostasis/metabolism
• stimulated Th2 cells exhibit an increase in IL4 production

Mouse Models of Human Disease
OMIM ID Ref(s)
Asthma, Susceptibility to 600807 J:152376




Genotype
MGI:4361939
cx2
Allelic
Composition
Il4ratm2Tch/Il4ratm2Tch
Tg(Scgb1a1-rtTA,tetO-Il13)1Eli/?
Genetic
Background
B6.Cg-Il4ratm2Tch Tg(Scgb1a1-rtTA,tetO-IL13)1Eli
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il4ratm2Tch mutation (1 available); any Il4ra mutation (15 available)
Tg(Scgb1a1-rtTA,tetO-Il13)1Eli mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
respiratory system
• basal airway eosinophilia
• percentage of goblet cells quadruples in mutant mice upon administration of doxycycline as compared to doubling in the control

immune system
• basal airway eosinophilia is increased as compared to Q576 IL-13tg control
• administration of doxycycline amplifies difference
• basal airway eosinophilia

hematopoietic system
• basal airway eosinophilia is increased as compared to Q576 IL-13tg control
• administration of doxycycline amplifies difference





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory