Mouse Genome Informatics
hm1
    Il4ratm2Tch/Il4ratm2Tch
C.129X1-Il4ratm2Tch
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
respiratory system
• mutant mice exhibit airway inflammation following chronic allergen challenge
• increase in peribronchial and perivascular inflammation compared with control
• OVA sensitized and challenged mutant (R576) mice exhibit patchy peribronchial inflammatory infiltrate that is more prominent that in Q576 controls
• peribronchial infiltrate is composed primarily of eosinophils and lymphoctyes
• OVA or IL13 challenged mice exhibit goblet cell hyperplasia
• enhanced response to IL13 challenge

immune system
• increase in eosinophils found in lung parenchyma of OVA sensitized mutant mice
• increase in monocytes found in lung parenchyma of OVA sensitized mutant mice
• following immunization with OVA or alum
• stimulated Th2 cells exhibit an increase in IL4 production, but not IL5 or IL13
• stimulated Th2 cells exhibit an increase in IL4 production
• enhanced allergic inflammatory response following IL13 challenge
• mutant mice exhibit airway inflammation following chronic allergen challenge
• increase in peribronchial and perivascular inflammation compared with control

hematopoietic system
• increase in eosinophils found in lung parenchyma of OVA sensitized mutant mice
• increase in monocytes found in lung parenchyma of OVA sensitized mutant mice
• following immunization with OVA or alum
• stimulated Th2 cells exhibit an increase in IL4 production, but not IL5 or IL13

homeostasis/metabolism
• stimulated Th2 cells exhibit an increase in IL4 production

Mouse Models of Human Disease
OMIM IDRef(s)
Asthma, Susceptibility to 600807 J:152376


Mouse Genome Informatics
cx2
    Il4ratm2Tch/Il4ratm2Tch
Tg(Scgb1a1-rtTA,tetO-Il13)1Eli/?

B6.Cg-Il4ratm2Tch Tg(Scgb1a1-rtTA,tetO-IL13)1Eli
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
respiratory system
• basal airway eosinophilia
• percentage of goblet cells quadruples in mutant mice upon administration of doxycycline as compared to doubling in the control

immune system
• basal airway eosinophilia is increased as compared to Q576 IL-13tg control
• administration of doxycycline amplifies difference
• basal airway eosinophilia

hematopoietic system
• basal airway eosinophilia is increased as compared to Q576 IL-13tg control
• administration of doxycycline amplifies difference