Phenotypes associated with this allele

• Allele Symbol: Abca2^tm1Nina
• Allele Name: targeted mutation 1, Nobuya Inagaki
• Allele ID: MGI:3719855
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Abca2^tm1Nina/Abca2^tm1Nina	involves: 129X1/SvJ * C57BL/6	MGI:3720093

Genotype
MGI:3720093

hm1

• Allelic Composition: Abca2^tm1Nina/Abca2^tm1Nina
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:123521 )

• when moved onto wet sawdust (to evaluate response to stress) death rate of mice increases much more than in wild-type mice

reproductive system

reduced female fertility ( J:123521 )

♀ • 1 week fertility rates are lower (38.6%, n=83) compared to wild-type rates (68.1%, n=69)

behavior/neurological

abnormal emotion/affect behavior ( J:123521 )

• when moved onto wet sawdust (to evaluate response to stress) death rate of mice increases much more than in wild-type mice

tremors ( J:123521 )

• when hung vertically with their tails upwards mice extend their limbs similar to the parachute reflex in human infants but their hind limbs shake

impaired balance ( J:123521 )

• at week 18, mice have a shorter latency on the balance beam compared to wild-type mice

homeostasis/metabolism

abnormal lipid level ( J:123521 )

• mice have less sphingomyelin in their brain after growth stage

• ganglioside GM1, cerebrosides and silfatides levels are increased

• however, cholesterol and glycerophospholipid levels are normal

growth/size/body

decreased body weight ( J:123521 )

• at 5, 10 and 18 weeks mice weight less than wild-type