Mouse Genome Informatics
cx1
    Tg(APP)8.9Btla/Tg(APP)8.9Btla
Tg(SOD1)51Yg/Tg(SOD1)51Yg

involves: 129S2/SvPas * BALB/c * C57BL/6J * DBA/2
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
behavior/neurological
• mice spend greater amounts of time in the closed arms of an elevated plus maze than Tg(SOD1)51Yg or Tg(APP)8.9Btla mice; time per entry into dark arms is increased relative to Tg(APP)8.9Btla mice and total entries into dark arms is greater than controls
• mice spend much more time in dark side of dark-light box than either single transgenic line or controls
• 9-month old mice show impaired memory retention in Morris water maze, exhibiting delayed escape latency compared to controls in all 6 trials
• exploratory behavior is increased for both familiar and novel objects
• impairment observed at 10 months of age; mice show greater impairment than Tg(APP)8.9Btla mice
• at 9 months, a delay of learning process in Morris water maze is observed compared to controls; double mutants are significantly impaired relative to controls
• at 4.5 months of age, rate of learning platform position during first day of Morris water maze testing is impaired compared to controls or Tg(APP)8.9Btla/Tg(SOD1)69Yg double mutants
• transgenic mice display more spontaneous locomotor activity than controls

nervous system
• mic show a 2-fold increase of cortical APP proteins and a 2.5-2.8-fold increase in hippocampal APP levels compared to Tg(APP)8.9Btla mice
• no Abeta peptides are detected in 5 month old mice
• LTP is impaired


Mouse Genome Informatics
tg2
    Tg(SOD1)51Yg/Tg(SOD1)51Yg
involves: BALB/c * C57BL/6J * DBA/2
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
growth/size
• mice are smaller than Tg(SOD1)69Yg mice
• weight is lower than controls or Tg(SOD1)69Yg mice

behavior/neurological
• mice spend less time in the closed arms than controls; time/entry is lower than in controls as well
• mice exit dark side of dark-light box more often than controls
• exhibit lower muscular strength than non-transgenic control mice
• transgenic mice display more spontaneous locomotor activity than controls
• lower pain thresholds than non-transgenic controls

nervous system
• LTP is impaired

integument
• lower pain thresholds than non-transgenic controls