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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(SOD1)51Yg
transgene insertion 51, Yoram Groner
MGI:3718455
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Tg(APP)8.9Btla/Tg(APP)8.9Btla
Tg(SOD1)51Yg/Tg(SOD1)51Yg
involves: 129S2/SvPas * BALB/c * C57BL/6J * DBA/2 MGI:3718511
tg2
Tg(SOD1)51Yg/Tg(SOD1)51Yg involves: BALB/c * C57BL/6J * DBA/2 MGI:3718509


Genotype
MGI:3718511
cx1
Allelic
Composition
Tg(APP)8.9Btla/Tg(APP)8.9Btla
Tg(SOD1)51Yg/Tg(SOD1)51Yg
Genetic
Background
involves: 129S2/SvPas * BALB/c * C57BL/6J * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(APP)8.9Btla mutation (1 available)
Tg(SOD1)51Yg mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice spend greater amounts of time in the closed arms of an elevated plus maze than Tg(SOD1)51Yg or Tg(APP)8.9Btla mice; time per entry into dark arms is increased relative to Tg(APP)8.9Btla mice and total entries into dark arms is greater than controls (J:96742)
• mice spend much more time in dark side of dark-light box than either single transgenic line or controls (J:96742)
• mice spend greater amounts of time in the closed arms of an elevated plus maze than Tg(SOD1)51Yg or Tg(APP)8.9Btla mice; time per entry into dark arms is increased relative to Tg(APP)8.9Btla mice and total entries into dark arms is greater than controls (J:96742)
• mice spend much more time in dark side of dark-light box than either single transgenic line or controls (J:96742)
• 9-month old mice show impaired memory retention in Morris water maze, exhibiting delayed escape latency compared to controls in all 6 trials (J:96742)
• 9-month old mice show impaired memory retention in Morris water maze, exhibiting delayed escape latency compared to controls in all 6 trials (J:96742)
• exploratory behavior is increased for both familiar and novel objects (J:96742)
• exploratory behavior is increased for both familiar and novel objects (J:96742)
• impairment observed at 10 months of age; mice show greater impairment than Tg(APP)8.9Btla mice (J:96742)
• impairment observed at 10 months of age; mice show greater impairment than Tg(APP)8.9Btla mice (J:96742)
• at 9 months, a delay of learning process in Morris water maze is observed compared to controls; double mutants are significantly impaired relative to controls (J:96742)
• at 4.5 months of age, rate of learning platform position during first day of Morris water maze testing is impaired compared to controls or Tg(APP)8.9Btla/Tg(SOD1)69Yg double mutants (J:96742)
• at 9 months, a delay of learning process in Morris water maze is observed compared to controls; double mutants are significantly impaired relative to controls (J:96742)
• at 4.5 months of age, rate of learning platform position during first day of Morris water maze testing is impaired compared to controls or Tg(APP)8.9Btla/Tg(SOD1)69Yg double mutants (J:96742)
• transgenic mice display more spontaneous locomotor activity than controls (J:96742)
• transgenic mice display more spontaneous locomotor activity than controls (J:96742)

nervous system
• mic show a 2-fold increase of cortical APP proteins and a 2.5-2.8-fold increase in hippocampal APP levels compared to Tg(APP)8.9Btla mice (J:96742)
• no Abeta peptides are detected in 5 month old mice (J:96742)
• mic show a 2-fold increase of cortical APP proteins and a 2.5-2.8-fold increase in hippocampal APP levels compared to Tg(APP)8.9Btla mice (J:96742)
• no Abeta peptides are detected in 5 month old mice (J:96742)
• LTP is impaired (J:96742)
• LTP is impaired (J:96742)




Genotype
MGI:3718509
tg2
Allelic
Composition
Tg(SOD1)51Yg/Tg(SOD1)51Yg
Genetic
Background
involves: BALB/c * C57BL/6J * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• mice are smaller than Tg(SOD1)69Yg mice (J:96742)
• mice are smaller than Tg(SOD1)69Yg mice (J:96742)
• weight is lower than controls or Tg(SOD1)69Yg mice (J:96742)
• weight is lower than controls or Tg(SOD1)69Yg mice (J:96742)

behavior/neurological
• mice spend less time in the closed arms than controls; time/entry is lower than in controls as well (J:96742)
• mice exit dark side of dark-light box more often than controls (J:96742)
• mice spend less time in the closed arms than controls; time/entry is lower than in controls as well (J:96742)
• mice exit dark side of dark-light box more often than controls (J:96742)
• exhibit lower muscular strength than non-transgenic control mice (J:96742)
• exhibit lower muscular strength than non-transgenic control mice (J:96742)
• transgenic mice display more spontaneous locomotor activity than controls (J:96742)
• transgenic mice display more spontaneous locomotor activity than controls (J:96742)
• lower pain thresholds than non-transgenic controls (J:96742)
• lower pain thresholds than non-transgenic controls (J:96742)

nervous system
• LTP is impaired (J:96742)
• LTP is impaired (J:96742)

integument
• lower pain thresholds than non-transgenic controls (J:96742)
• lower pain thresholds than non-transgenic controls (J:96742)





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory