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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(PDGFB-APPSwInd)J9Lms
transgene insertion J9, Lennart Mucke
MGI:3717718
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Tg(Camk2a-tTA)1Mmay/0
Tg(PDGFB-APPSwInd)J9Lms/0
Tg(tetO-MAPT*A152T)L1Lms/0
involves: C57BL/6 * C57BL/6J * DBA/2 MGI:5828495
tg2
Tg(PDGFB-APPSwInd)J9Lms/0 involves: C57BL/6 * DBA/2 MGI:3784684


Genotype
MGI:5828495
cx1
Allelic
Composition
Tg(Camk2a-tTA)1Mmay/0
Tg(PDGFB-APPSwInd)J9Lms/0
Tg(tetO-MAPT*A152T)L1Lms/0
Genetic
Background
involves: C57BL/6 * C57BL/6J * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Camk2a-tTA)1Mmay mutation (8 available)
Tg(PDGFB-APPSwInd)J9Lms mutation (0 available)
Tg(tetO-MAPT*A152T)L1Lms mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• fewer than the expected numbers (8 of 282) of mice were obtained
• surviving mice do not die before adulthood, with one dying at 7 months, another at 10 months and the remaining being alive at 11-17 months

nervous system
• EEG recordings show more abundant epileptic spikes than in controls




Genotype
MGI:3784684
tg2
Allelic
Composition
Tg(PDGFB-APPSwInd)J9Lms/0
Genetic
Background
involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• at 5 to 7 months, mice exhibit amloid beta plaques
• between 16 and 21 months, all mice develop amyloid beta plaques
• neurodegeneration is indicated by an age dependent decrease in density of synaptophysin-immunoreactive presynaptic terminals

homeostasis/metabolism
• at 5 to 7 months, mice exhibit amloid beta plaques
• between 16 and 21 months, all mice develop amyloid beta plaques

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Alzheimer's disease DOID:10652 OMIM:104300
OMIM:502500
OMIM:604154
OMIM:608907
J:62290





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last database update
10/17/2017
MGI 6.10
The Jackson Laboratory