Phenotypes associated with this allele

• Allele Symbol: Il31ra^tm1Ngh
• Allele Name: targeted mutation 1, Nico Ghilardi
• Allele ID: MGI:3717594
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Il31ra^tm1Ngh/Il31ra^tm1Ngh	C57BL/6-Il31ra^tm1Ngh	MGI:3717903
hm2	Il31ra^tm1Ngh/Il31ra^tm1Ngh	involves: C57BL/6	MGI:3717919

Genotype
MGI:3717903

hm1

• Allelic Composition: Il31ra^tm1Ngh/Il31ra^tm1Ngh
• Genetic Background: C57BL/6-Il31ra^tm1Ngh

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal bone marrow cell morphology/development ( J:123111 )

• bone marrow colony-forming units granulocyte-macrophage (CFU-GM), erythropoietic burst formation (BFU-E), and colony-forming unit-granulocyte, erythrocyte, monocyte (CFU-GEMM) cells do not experience survival-enhanced activity in response to Pokeweed mitogen mouse spleen cell conditioned medium (PWMSCM) and stem cell factor (SCF)

abnormal common myeloid progenitor cell morphology ( J:123111 )

• fewer colony-forming units granulocyte-macrophage (CFU-GM) per femur are responsive to cytokine stimulation in vitro

• in vitro, the effects of granulocyte-macrophage colony stimulating factor or IL-3 with stem cell factor (SCF) or FLT3 ligand (FL) on CFU-GM is additive compared to in wild-type where the response is synergistic

decreased bone marrow cell number ( J:123111 )

• fewer hematopoeitic progenitor cells are detected and those present are in slow or noncycling states

spleen hypoplasia ( J:123111 )

• fewer hematopoeitic progenitor cells are detected and those present are in slow or noncycling states

immune system

spleen hypoplasia ( J:123111 )

• fewer hematopoeitic progenitor cells are detected and those present are in slow or noncycling states

Genotype
MGI:3717919

hm2

• Allelic Composition: Il31ra^tm1Ngh/Il31ra^tm1Ngh
• Genetic Background: involves: C57BL/6

immune system

increased T cell proliferation ( J:123198 )

• CD4+ T cell proliferation is increased compared to in wild-type mice

increased IgE level ( J:123198 )

• following infection with Schistosoma mansoni eggs, mice produce higher levels of IgE in lymph node cells

abnormal macrophage physiology ( J:123198 )

• macrophages exhibit enhanced accessory cell function

abnormal interleukin level ( J:123198 )

• following infection with Schistosoma mansoni eggs, mice produce higher levels of IL-4, IL-5 and IL-13 in lymph node cells

granulomatous inflammation ( J:123198 )

• following infection with Schistosoma mansoni eggs, granuloma size is increased

• following infection with Schistosoma mansoni eggs, the number of RELM-alpha+ cells is increased in the lung gramulomas

increased susceptibility to parasitic infection ( J:123198 )

• following infection with Schistosoma mansoni eggs, mice have an increased inflammation response and affected area in the lungs compared to wild-type, produce higher levels of IL-4, IL-5, IL-13 and IgE, have increased granuloma size , and the number of RELM-alpha+ cells is increased in the lung gramulomas

hematopoietic system

increased T cell proliferation ( J:123198 )

• CD4+ T cell proliferation is increased compared to in wild-type mice

increased IgE level ( J:123198 )

• following infection with Schistosoma mansoni eggs, mice produce higher levels of IgE in lymph node cells

abnormal macrophage physiology ( J:123198 )

• macrophages exhibit enhanced accessory cell function

homeostasis/metabolism

abnormal interleukin level ( J:123198 )

• following infection with Schistosoma mansoni eggs, mice produce higher levels of IL-4, IL-5 and IL-13 in lymph node cells

cellular

increased T cell proliferation ( J:123198 )

• CD4+ T cell proliferation is increased compared to in wild-type mice