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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Thy1-APPLon)2Vln
transgene insertion 2, Fred Van Leuven
MGI:3717572
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Psen1tm1Vln/Psen1tm1Vln
Tg(Thy1-APPLon)2Vln/0
Tg(Thy1-cre)1Vln/0
involves: FVB/N MGI:2684658
cx2
Tg(Hmgcr-PSEN1*M146L)#Lpr/0
Tg(Thy1-APPLon)2Vln/0
involves: C57BL/6 * CBA * FVB/N MGI:5003462
cx3
Tg(Thy1-APPLon)2Vln/0
Tg(Thy1-BACE1)16Vln/0
involves: C57BL/6 * DBA * FVB/N MGI:3722143
cx4
Tg(Thy1-APPLon)2Vln/0
Tg(Thy1-PSEN1*A246E)2Vln/0
involves: FVB/N MGI:3717644
tg5
Tg(Thy1-APPLon)2Vln/0 (C57BL/6 x FVB/N)F1 MGI:3717578
tg6
Tg(Thy1-APPLon)2Vln/0 involves: C57BL/6 * CBA * FVB/N MGI:5003461
tg7
Tg(Thy1-APPLon)2Vln/0 involves: FVB/N MGI:3717577


Genotype
MGI:2684658
cn1
Allelic
Composition
Psen1tm1Vln/Psen1tm1Vln
Tg(Thy1-APPLon)2Vln/0
Tg(Thy1-cre)1Vln/0
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1tm1Vln mutation (2 available); any Psen1 mutation (34 available)
Tg(Thy1-APPLon)2Vln mutation (0 available)
Tg(Thy1-cre)1Vln mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• retention of object recognition is normal at 1 hr after training but testing of animals 3 hours after familiarization with an object reveals significant impairment relative to controls

nervous system
N
• no thioflavin-S-reactive amyloid plaques or diffuse amyloid deposits are detected in mice up to 18 months of age
• with tetanic stimulation of hippocampal slices, after an initial slight decrease, the slope of the fEPSP approached control levels; LTP in transgenic brain slices is comparable to controls




Genotype
MGI:5003462
cx2
Allelic
Composition
Tg(Hmgcr-PSEN1*M146L)#Lpr/0
Tg(Thy1-APPLon)2Vln/0
Genetic
Background
involves: C57BL/6 * CBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• plaques are seen at 6 months of age
• as soon as detectable, a large number of deposits have a fibrillar conformation

homeostasis/metabolism
• plaques are seen at 6 months of age
• as soon as detectable, a large number of deposits have a fibrillar conformation

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Alzheimer's disease DOID:10652 OMIM:104300
OMIM:502500
OMIM:604154
OMIM:608907
J:86694




Genotype
MGI:3722143
cx3
Allelic
Composition
Tg(Thy1-APPLon)2Vln/0
Tg(Thy1-BACE1)16Vln/0
Genetic
Background
involves: C57BL/6 * DBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• fibrillar thioflavin-S positive amyloid plaques are significantly increased in subiculum region of brain compared to Tg(APPV717I)1130Kha single transgenics
• decrease in vascular amyloid deposition is found in double transgenics relative to single mutant animals
• by 15 months, subiculum is almost totally covered with diffuse and senile plaques
• at 15 months and older, surface of cerebral cortex is occupied by thioflavin-S- and amyloid beta-positive deposits is 3-5-fold greater than in age-matched Tg(APPV717I)1130Kha mice
• dystrophic neurites with swollen and distorted neuritic profiles are identified in brains of mice

homeostasis/metabolism
• total levels of intact amyloid beta-40 and-42 peptides are increased by ~3-fold in older mice relative to single transgenic mice
• fibrillar thioflavin-S positive amyloid plaques are significantly increased in subiculum region of brain compared to Tg(APPV717I)1130Kha single transgenics
• decrease in vascular amyloid deposition is found in double transgenics relative to single mutant animals

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Alzheimer's disease DOID:10652 OMIM:104300
OMIM:502500
OMIM:604154
OMIM:608907
J:93635




Genotype
MGI:3717644
cx4
Allelic
Composition
Tg(Thy1-APPLon)2Vln/0
Tg(Thy1-PSEN1*A246E)2Vln/0
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• amyloid deposition occurs at 6-9 months in double mutants compared to 12-15 months in single APP transgenic mice; Abeta 42/Abeta 40 ratio is increased in young and aged mice with ratio of 3.11 at 15 months compared to 0.43 in Tg(Thy1-APP*V642I)2Vln mice at 6-9 months
• plaque-associated peptides are dramatically high in brains of double mutant mice aged 6-9 months

homeostasis/metabolism
• amyloid deposition occurs at 6-9 months in double mutants compared to 12-15 months in single APP transgenic mice; Abeta 42/Abeta 40 ratio is increased in young and aged mice with ratio of 3.11 at 15 months compared to 0.43 in Tg(Thy1-APP*V642I)2Vln mice at 6-9 months
• plaque-associated peptides are dramatically high in brains of double mutant mice aged 6-9 months




Genotype
MGI:3717578
tg5
Allelic
Composition
Tg(Thy1-APPLon)2Vln/0
Genetic
Background
(C57BL/6 x FVB/N)F1
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• in forced swim test and a visible platform paradigm, transgenic mice perform comparably to controls indicating normal motor abilities and motivation
• in Morris water maze test hidden platform tests, 3-6 month old mice show significantly longer escape latencies (measure of spatial learning and memory) than non-transgenic controls
• when platform is removed, 3-6 month old mutants spend less time crossing area of the platform's former location than controls, indicating impaired cognition




Genotype
MGI:5003461
tg6
Allelic
Composition
Tg(Thy1-APPLon)2Vln/0
Genetic
Background
involves: C57BL/6 * CBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• plaques are seen at 13 months of age
• clusters of swollen and abnormally distorted neuritic profiles are seen

homeostasis/metabolism
• plaques are seen at 13 months of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Alzheimer's disease DOID:10652 OMIM:104300
OMIM:502500
OMIM:604154
OMIM:608907
J:86694




Genotype
MGI:3717577
tg7
Allelic
Composition
Tg(Thy1-APPLon)2Vln/0
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 47.1% of animals died by 180 days of age; mortality by 360 days is 70.6% compared to 4.3% in controls

nervous system
• less than 15% of mice older than 6 months display spontaneous seizures
• diffuse amyloid plaques and compact neuritic plaques are detected in all mice 13-18 months old, most abundant in the hippocampus and cortex while occasionally seen in the thalamus, fimbria, external capsule, pontine nuclei, and white matter; plaques contain high amounts of the Abeta 42 peptidediffuse amyloid plaques and compact neuritic plaques are detected in all mice 13-18 months old, most abundant in the hippocampus and cortex while occasionally seen in the thalamus, fimbria, external capsule, pontine nuclei, and white matter; plaques contain high amounts of the Abeta 42 peptide (J:53800)
• mice younger than 12 months do not exhibit amyloid deposits (J:53800)
• levels of plaque peptides extracted with guanidinium hydrochloride increase exponentially in mutants >15 months of age; plaque associated peptides are not detected in brains of mice at 6-9 months of age (J:64209)
• subiculum region of brain is loaded amyloid deposits starting at 10 months of age (J:93635)
• amyloid deposits are found in the parenchyma and in cortical and leptimenigeal arterioles in brains at 16 months
• by 15 months, subiculum is almost totally covered with diffuse and senile plaques
• dystrophic neurites with swollen and distorted neuritic profiles are identified in brains of mice
• tetanic stimulation in hippocampal brain slices triggers significantly impaired LTP; LTP progressively decreases in brain slices (J:87229)

behavior/neurological
• ambulation measured in a corner-crossing variant upon transfer to a new cage is reduced relative to controls at 4-9 weeks of age, 12-17, and 20-52 weeks with differences becoming more pronounced with age
• mice exhibit increased episodes of agitation and spontaneous activity by 8 weeks of age onward
• less than 15% of mice older than 6 months display spontaneous seizures

homeostasis/metabolism
• in brains of 10-12 month-old mice, diffuse and senile amyloid plaques are present and increase exponentially with age (J:87229)
• diffuse amyloid plaques and compact neuritic plaques are detected in all mice 13-18 months old, most abundant in the hippocampus and cortex while occasionally seen in the thalamus, fimbria, external capsule, pontine nuclei, and white matter; plaques contain high amounts of the Abeta 42 peptidediffuse amyloid plaques and compact neuritic plaques are detected in all mice 13-18 months old, most abundant in the hippocampus and cortex while occasionally seen in the thalamus, fimbria, external capsule, pontine nuclei, and white matter; plaques contain high amounts of the Abeta 42 peptide (J:53800)
• mice younger than 12 months do not exhibit amyloid deposits (J:53800)
• levels of plaque peptides extracted with guanidinium hydrochloride increase exponentially in mutants >15 months of age; plaque associated peptides are not detected in brains of mice at 6-9 months of age (J:64209)
• subiculum region of brain is loaded amyloid deposits starting at 10 months of age (J:93635)
• amyloid deposits are found in the parenchyma and in cortical and leptimenigeal arterioles in brains at 16 months

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Alzheimer's disease DOID:10652 OMIM:104300
OMIM:502500
OMIM:604154
OMIM:608907
J:93635





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last database update
08/15/2017
MGI 6.10
The Jackson Laboratory