Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1tm1Vln mutation
(2 available);
any
Psen1 mutation
(46 available)
Tg(Thy1-APPLon)2Vln mutation
(0 available)
Tg(Thy1-cre)1Vln mutation
(1 available)
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behavior/neurological
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• retention of object recognition is normal at 1 hr after training but testing of animals 3 hours after familiarization with an object reveals significant impairment relative to controls
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nervous system
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N |
• no thioflavin-S-reactive amyloid plaques or diffuse amyloid deposits are detected in mice up to 18 months of age
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• with tetanic stimulation of hippocampal slices, after an initial slight decrease, the slope of the fEPSP approached control levels; LTP in transgenic brain slices is comparable to controls
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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nervous system
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• plaques are seen at 6 months of age
• as soon as detectable, a large number of deposits have a fibrillar conformation
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homeostasis/metabolism
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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nervous system
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• fibrillar thioflavin-S positive amyloid plaques are significantly increased in subiculum region of brain compared to Tg(APPV717I)1130Kha single transgenics
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• decrease in vascular amyloid deposition is found in double transgenics relative to single mutant animals
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• by 15 months, subiculum is almost totally covered with diffuse and senile plaques
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• at 15 months and older, surface of cerebral cortex is occupied by thioflavin-S- and amyloid beta-positive deposits is 3-5-fold greater than in age-matched Tg(APPV717I)1130Kha mice
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• dystrophic neurites with swollen and distorted neuritic profiles are identified in brains of mice
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homeostasis/metabolism
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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nervous system
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• amyloid deposition occurs at 6-9 months in double mutants compared to 12-15 months in single APP transgenic mice; Abeta 42/Abeta 40 ratio is increased in young and aged mice with ratio of 3.11 at 15 months compared to 0.43 in Tg(Thy1-APP*V642I)2Vln mice at 6-9 months
• plaque-associated peptides are dramatically high in brains of double mutant mice aged 6-9 months
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homeostasis/metabolism
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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behavior/neurological
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N |
• in forced swim test and a visible platform paradigm, transgenic mice perform comparably to controls indicating normal motor abilities and motivation
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• in Morris water maze test hidden platform tests, 3-6 month old mice show significantly longer escape latencies (measure of spatial learning and memory) than non-transgenic controls
• when platform is removed, 3-6 month old mutants spend less time crossing area of the platform's former location than controls, indicating impaired cognition
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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nervous system
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• plaques are seen at 13 months of age
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• clusters of swollen and abnormally distorted neuritic profiles are seen
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homeostasis/metabolism
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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mortality/aging
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• 47.1% of animals died by 180 days of age; mortality by 360 days is 70.6% compared to 4.3% in controls
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nervous system
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• less than 15% of mice older than 6 months display spontaneous seizures
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• diffuse amyloid plaques and compact neuritic plaques are detected in all mice 13-18 months old, most abundant in the hippocampus and cortex while occasionally seen in the thalamus, fimbria, external capsule, pontine nuclei, and white matter; plaques contain high amounts of the Abeta 42 peptidediffuse amyloid plaques and compact neuritic plaques are detected in all mice 13-18 months old, most abundant in the hippocampus and cortex while occasionally seen in the thalamus, fimbria, external capsule, pontine nuclei, and white matter; plaques contain high amounts of the Abeta 42 peptide
(J:53800)
• mice younger than 12 months do not exhibit amyloid deposits
(J:53800)
• levels of plaque peptides extracted with guanidinium hydrochloride increase exponentially in mutants >15 months of age; plaque associated peptides are not detected in brains of mice at 6-9 months of age
(J:64209)
• subiculum region of brain is loaded amyloid deposits starting at 10 months of age
(J:93635)
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• amyloid deposits are found in the parenchyma and in cortical and leptimenigeal arterioles in brains at 16 months
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• by 15 months, subiculum is almost totally covered with diffuse and senile plaques
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• dystrophic neurites with swollen and distorted neuritic profiles are identified in brains of mice
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• tetanic stimulation in hippocampal brain slices triggers significantly impaired LTP; LTP progressively decreases in brain slices
(J:87229)
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behavior/neurological
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• ambulation measured in a corner-crossing variant upon transfer to a new cage is reduced relative to controls at 4-9 weeks of age, 12-17, and 20-52 weeks with differences becoming more pronounced with age
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• mice exhibit increased episodes of agitation and spontaneous activity by 8 weeks of age onward
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• less than 15% of mice older than 6 months display spontaneous seizures
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homeostasis/metabolism
Analysis Tools