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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Thy1-APPLon)2Vln
transgene insertion 2, Fred Van Leuven
MGI:3717572
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Psen1tm1Vln/Psen1tm1Vln
Tg(Thy1-APPLon)2Vln/0
Tg(Thy1-cre)1Vln/0
involves: FVB/N MGI:2684658
cx2
Tg(Hmgcr-PSEN1*M146L)#Lpr/0
Tg(Thy1-APPLon)2Vln/0
involves: C57BL/6 * CBA * FVB/N MGI:5003462
cx3
Tg(Thy1-APPLon)2Vln/0
Tg(Thy1-BACE1)16Vln/0
involves: C57BL/6 * DBA * FVB/N MGI:3722143
cx4
Tg(Thy1-APPLon)2Vln/0
Tg(Thy1-PSEN1*A246E)2Vln/0
involves: FVB/N MGI:3717644
tg5
Tg(Thy1-APPLon)2Vln/0 (C57BL/6 x FVB/N)F1 MGI:3717578
tg6
Tg(Thy1-APPLon)2Vln/0 involves: C57BL/6 * CBA * FVB/N MGI:5003461
tg7
Tg(Thy1-APPLon)2Vln/0 involves: FVB/N MGI:3717577


Genotype
MGI:2684658
cn1
Allelic
Composition
Psen1tm1Vln/Psen1tm1Vln
Tg(Thy1-APPLon)2Vln/0
Tg(Thy1-cre)1Vln/0
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1tm1Vln mutation (2 available); any Psen1 mutation (22 available)
Tg(Thy1-APPLon)2Vln mutation (0 available)
Tg(Thy1-cre)1Vln mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• retention of object recognition is normal at 1 hr after training but testing of animals 3 hours after familiarization with an object reveals significant impairment relative to controls (J:87229)
• retention of object recognition is normal at 1 hr after training but testing of animals 3 hours after familiarization with an object reveals significant impairment relative to controls (J:87229)

nervous system
N
• no thioflavin-S-reactive amyloid plaques or diffuse amyloid deposits are detected in mice up to 18 months of age (J:87229)
• no thioflavin-S-reactive amyloid plaques or diffuse amyloid deposits are detected in mice up to 18 months of age (J:87229)
• with tetanic stimulation of hippocampal slices, after an initial slight decrease, the slope of the fEPSP approached control levels; LTP in transgenic brain slices is comparable to controls (J:87229)
• with tetanic stimulation of hippocampal slices, after an initial slight decrease, the slope of the fEPSP approached control levels; LTP in transgenic brain slices is comparable to controls (J:87229)




Genotype
MGI:5003462
cx2
Allelic
Composition
Tg(Hmgcr-PSEN1*M146L)#Lpr/0
Tg(Thy1-APPLon)2Vln/0
Genetic
Background
involves: C57BL/6 * CBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• plaques are seen at 6 months of age (J:86694)
• as soon as detectable, a large number of deposits have a fibrillar conformation (J:86694)
• plaques are seen at 6 months of age (J:86694)
• as soon as detectable, a large number of deposits have a fibrillar conformation (J:86694)

homeostasis/metabolism
• plaques are seen at 6 months of age (J:86694)
• as soon as detectable, a large number of deposits have a fibrillar conformation (J:86694)
• plaques are seen at 6 months of age (J:86694)
• as soon as detectable, a large number of deposits have a fibrillar conformation (J:86694)

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:86694




Genotype
MGI:3722143
cx3
Allelic
Composition
Tg(Thy1-APPLon)2Vln/0
Tg(Thy1-BACE1)16Vln/0
Genetic
Background
involves: C57BL/6 * DBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• fibrillar thioflavin-S positive amyloid plaques are significantly increased in subiculum region of brain compared to Tg(APPV717I)1130Kha single transgenics (J:93635)
• fibrillar thioflavin-S positive amyloid plaques are significantly increased in subiculum region of brain compared to Tg(APPV717I)1130Kha single transgenics (J:93635)
• decrease in vascular amyloid deposition is found in double transgenics relative to single mutant animals (J:93635)
• decrease in vascular amyloid deposition is found in double transgenics relative to single mutant animals (J:93635)
• by 15 months, subiculum is almost totally covered with diffuse and senile plaques (J:93635)
• by 15 months, subiculum is almost totally covered with diffuse and senile plaques (J:93635)
• at 15 months and older, surface of cerebral cortex is occupied by thioflavin-S- and amyloid beta-positive deposits is 3-5-fold greater than in age-matched Tg(APPV717I)1130Kha mice (J:93635)
• at 15 months and older, surface of cerebral cortex is occupied by thioflavin-S- and amyloid beta-positive deposits is 3-5-fold greater than in age-matched Tg(APPV717I)1130Kha mice (J:93635)
• dystrophic neurites with swollen and distorted neuritic profiles are identified in brains of mice (J:93635)
• dystrophic neurites with swollen and distorted neuritic profiles are identified in brains of mice (J:93635)

homeostasis/metabolism
• total levels of intact amyloid beta-40 and-42 peptides are increased by ~3-fold in older mice relative to single transgenic mice (J:93635)
• total levels of intact amyloid beta-40 and-42 peptides are increased by ~3-fold in older mice relative to single transgenic mice (J:93635)
• fibrillar thioflavin-S positive amyloid plaques are significantly increased in subiculum region of brain compared to Tg(APPV717I)1130Kha single transgenics (J:93635)
• fibrillar thioflavin-S positive amyloid plaques are significantly increased in subiculum region of brain compared to Tg(APPV717I)1130Kha single transgenics (J:93635)
• decrease in vascular amyloid deposition is found in double transgenics relative to single mutant animals (J:93635)
• decrease in vascular amyloid deposition is found in double transgenics relative to single mutant animals (J:93635)

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:93635




Genotype
MGI:3717644
cx4
Allelic
Composition
Tg(Thy1-APPLon)2Vln/0
Tg(Thy1-PSEN1*A246E)2Vln/0
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• amyloid deposition occurs at 6-9 months in double mutants compared to 12-15 months in single APP transgenic mice; Abeta 42/Abeta 40 ratio is increased in young and aged mice with ratio of 3.11 at 15 months compared to 0.43 in Tg(Thy1-APP*V642I)2Vln mice at 6-9 months (J:64209)
• plaque-associated peptides are dramatically high in brains of double mutant mice aged 6-9 months (J:64209)
• amyloid deposition occurs at 6-9 months in double mutants compared to 12-15 months in single APP transgenic mice; Abeta 42/Abeta 40 ratio is increased in young and aged mice with ratio of 3.11 at 15 months compared to 0.43 in Tg(Thy1-APP*V642I)2Vln mice at 6-9 months (J:64209)
• plaque-associated peptides are dramatically high in brains of double mutant mice aged 6-9 months (J:64209)

homeostasis/metabolism
• amyloid deposition occurs at 6-9 months in double mutants compared to 12-15 months in single APP transgenic mice; Abeta 42/Abeta 40 ratio is increased in young and aged mice with ratio of 3.11 at 15 months compared to 0.43 in Tg(Thy1-APP*V642I)2Vln mice at 6-9 months (J:64209)
• plaque-associated peptides are dramatically high in brains of double mutant mice aged 6-9 months (J:64209)
• amyloid deposition occurs at 6-9 months in double mutants compared to 12-15 months in single APP transgenic mice; Abeta 42/Abeta 40 ratio is increased in young and aged mice with ratio of 3.11 at 15 months compared to 0.43 in Tg(Thy1-APP*V642I)2Vln mice at 6-9 months (J:64209)
• plaque-associated peptides are dramatically high in brains of double mutant mice aged 6-9 months (J:64209)




Genotype
MGI:3717578
tg5
Allelic
Composition
Tg(Thy1-APPLon)2Vln/0
Genetic
Background
(C57BL/6 x FVB/N)F1
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• in forced swim test and a visible platform paradigm, transgenic mice perform comparably to controls indicating normal motor abilities and motivation (J:53800)
• in forced swim test and a visible platform paradigm, transgenic mice perform comparably to controls indicating normal motor abilities and motivation (J:53800)
• in Morris water maze test hidden platform tests, 3-6 month old mice show significantly longer escape latencies (measure of spatial learning and memory) than non-transgenic controls (J:53800)
• when platform is removed, 3-6 month old mutants spend less time crossing area of the platform's former location than controls, indicating impaired cognition (J:53800)
• in Morris water maze test hidden platform tests, 3-6 month old mice show significantly longer escape latencies (measure of spatial learning and memory) than non-transgenic controls (J:53800)
• when platform is removed, 3-6 month old mutants spend less time crossing area of the platform's former location than controls, indicating impaired cognition (J:53800)




Genotype
MGI:5003461
tg6
Allelic
Composition
Tg(Thy1-APPLon)2Vln/0
Genetic
Background
involves: C57BL/6 * CBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• plaques are seen at 13 months of age (J:86694)
• plaques are seen at 13 months of age (J:86694)
• clusters of swollen and abnormally distorted neuritic profiles are seen (J:86694)
• clusters of swollen and abnormally distorted neuritic profiles are seen (J:86694)

homeostasis/metabolism
• plaques are seen at 13 months of age (J:86694)
• plaques are seen at 13 months of age (J:86694)

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:86694




Genotype
MGI:3717577
tg7
Allelic
Composition
Tg(Thy1-APPLon)2Vln/0
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 47.1% of animals died by 180 days of age; mortality by 360 days is 70.6% compared to 4.3% in controls (J:53800)
• 47.1% of animals died by 180 days of age; mortality by 360 days is 70.6% compared to 4.3% in controls (J:53800)

nervous system
• less than 15% of mice older than 6 months display spontaneous seizures (J:53800)
• less than 15% of mice older than 6 months display spontaneous seizures (J:53800)
• diffuse amyloid plaques and compact neuritic plaques are detected in all mice 13-18 months old, most abundant in the hippocampus and cortex while occasionally seen in the thalamus, fimbria, external capsule, pontine nuclei, and white matter; plaques contain high amounts of the Abeta 42 peptidediffuse amyloid plaques and compact neuritic plaques are detected in all mice 13-18 months old, most abundant in the hippocampus and cortex while occasionally seen in the thalamus, fimbria, external capsule, pontine nuclei, and white matter; plaques contain high amounts of the Abeta 42 peptide (J:53800)
• mice younger than 12 months do not exhibit amyloid deposits (J:53800)
• diffuse amyloid plaques and compact neuritic plaques are detected in all mice 13-18 months old, most abundant in the hippocampus and cortex while occasionally seen in the thalamus, fimbria, external capsule, pontine nuclei, and white matter; plaques contain high amounts of the Abeta 42 peptidediffuse amyloid plaques and compact neuritic plaques are detected in all mice 13-18 months old, most abundant in the hippocampus and cortex while occasionally seen in the thalamus, fimbria, external capsule, pontine nuclei, and white matter; plaques contain high amounts of the Abeta 42 peptide (J:53800)
• mice younger than 12 months do not exhibit amyloid deposits (J:53800)
• levels of plaque peptides extracted with guanidinium hydrochloride increase exponentially in mutants >15 months of age; plaque associated peptides are not detected in brains of mice at 6-9 months of age (J:64209)
• levels of plaque peptides extracted with guanidinium hydrochloride increase exponentially in mutants >15 months of age; plaque associated peptides are not detected in brains of mice at 6-9 months of age (J:64209)
• subiculum region of brain is loaded amyloid deposits starting at 10 months of age (J:93635)
• subiculum region of brain is loaded amyloid deposits starting at 10 months of age (J:93635)
• amyloid deposits are found in the parenchyma and in cortical and leptimenigeal arterioles in brains at 16 months (J:93635)
• amyloid deposits are found in the parenchyma and in cortical and leptimenigeal arterioles in brains at 16 months (J:93635)
• by 15 months, subiculum is almost totally covered with diffuse and senile plaques (J:93635)
• by 15 months, subiculum is almost totally covered with diffuse and senile plaques (J:93635)
• dystrophic neurites with swollen and distorted neuritic profiles are identified in brains of mice (J:93635)
• dystrophic neurites with swollen and distorted neuritic profiles are identified in brains of mice (J:93635)
• tetanic stimulation in hippocampal brain slices triggers significantly impaired LTP; LTP progressively decreases in brain slices (J:87229)
• tetanic stimulation in hippocampal brain slices triggers significantly impaired LTP; LTP progressively decreases in brain slices (J:87229)

behavior/neurological
• ambulation measured in a corner-crossing variant upon transfer to a new cage is reduced relative to controls at 4-9 weeks of age, 12-17, and 20-52 weeks with differences becoming more pronounced with age (J:53800)
• ambulation measured in a corner-crossing variant upon transfer to a new cage is reduced relative to controls at 4-9 weeks of age, 12-17, and 20-52 weeks with differences becoming more pronounced with age (J:53800)
• mice exhibit increased episodes of agitation and spontaneous activity by 8 weeks of age onward (J:53800)
• mice exhibit increased episodes of agitation and spontaneous activity by 8 weeks of age onward (J:53800)
• less than 15% of mice older than 6 months display spontaneous seizures (J:53800)
• less than 15% of mice older than 6 months display spontaneous seizures (J:53800)

homeostasis/metabolism
• in brains of 10-12 month-old mice, diffuse and senile amyloid plaques are present and increase exponentially with age (J:87229)
• in brains of 10-12 month-old mice, diffuse and senile amyloid plaques are present and increase exponentially with age (J:87229)
• diffuse amyloid plaques and compact neuritic plaques are detected in all mice 13-18 months old, most abundant in the hippocampus and cortex while occasionally seen in the thalamus, fimbria, external capsule, pontine nuclei, and white matter; plaques contain high amounts of the Abeta 42 peptidediffuse amyloid plaques and compact neuritic plaques are detected in all mice 13-18 months old, most abundant in the hippocampus and cortex while occasionally seen in the thalamus, fimbria, external capsule, pontine nuclei, and white matter; plaques contain high amounts of the Abeta 42 peptide (J:53800)
• mice younger than 12 months do not exhibit amyloid deposits (J:53800)
• diffuse amyloid plaques and compact neuritic plaques are detected in all mice 13-18 months old, most abundant in the hippocampus and cortex while occasionally seen in the thalamus, fimbria, external capsule, pontine nuclei, and white matter; plaques contain high amounts of the Abeta 42 peptidediffuse amyloid plaques and compact neuritic plaques are detected in all mice 13-18 months old, most abundant in the hippocampus and cortex while occasionally seen in the thalamus, fimbria, external capsule, pontine nuclei, and white matter; plaques contain high amounts of the Abeta 42 peptide (J:53800)
• mice younger than 12 months do not exhibit amyloid deposits (J:53800)
• levels of plaque peptides extracted with guanidinium hydrochloride increase exponentially in mutants >15 months of age; plaque associated peptides are not detected in brains of mice at 6-9 months of age (J:64209)
• levels of plaque peptides extracted with guanidinium hydrochloride increase exponentially in mutants >15 months of age; plaque associated peptides are not detected in brains of mice at 6-9 months of age (J:64209)
• subiculum region of brain is loaded amyloid deposits starting at 10 months of age (J:93635)
• subiculum region of brain is loaded amyloid deposits starting at 10 months of age (J:93635)
• amyloid deposits are found in the parenchyma and in cortical and leptimenigeal arterioles in brains at 16 months (J:93635)
• amyloid deposits are found in the parenchyma and in cortical and leptimenigeal arterioles in brains at 16 months (J:93635)

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:93635





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory