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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Thy1-MAPT)22Schd
transgene insertion 22, Katharina Schindowski
MGI:3717232
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(Thy1-MAPT)22Schd/0 B6.Cg-Tg(Thy1-MAPT)22Schd MGI:3717255
tg2
Tg(Thy1-MAPT)22Schd/0 involves: C57BL/6 * CBA MGI:5521287


Genotype
MGI:3717255
tg1
Allelic
Composition
Tg(Thy1-MAPT)22Schd/0
Genetic
Background
B6.Cg-Tg(Thy1-MAPT)22Schd
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• low level of mortality is displayed by transgenic mice, with 2 females (5-7 months of age) and 3 males (17 months of age) dying during course of study, compared to 0 controls

growth/size/body
• bodyweights of males and females are reduced by ~15% compared to wild-type littermates

behavior/neurological
N
• transgenic mice show no dysfunction of motor skills, motor impairment, or paralysis up to 18 months of age
• over a 4-day period, transgenic mice show significant delay in learning the location of the hidden platform in the Morris water maze task on days 2 and 3 compared to wild-type controls
• spatial memory is also significantly impaired in mice aged 10-14 months compared to wild-type controls
• mice spend more time in the open arms of an elevated-plus maze compared to wild-type littermate controls

nervous system
N
• in 6-7 month old mice, LTP remains normal
• by 3 months of age, abnormal MAPT (tau) species are observed early in CA1 pyramidal layer of hippocampus and spreading to detante gyrus and CA3; also seen in striatum, olfactory bulb, occipital cortex, amygdala, ventral thalamic nuclei, and deep layers of entorhinal cortex
• a slight reduction in number and size of tau-positive neurons in frontal cortex, CA1 and CA3 regions, and in neurites and fiber tracts of entire hippocampus is observed in mice >12 months of age
• ghost tangles are detected in CA1 by 12 months; in pyramidal neurons, fibrillary inclusions are ~19.4 nm in diameter, with largest having diameter of 31.9 nm, showing regular constrictions every ~129 nm
• before abnormal tau species are detected in neuron soma, they are detected in axonal tracts and neurites; older mice show intracellular inclusions in neuronal perikarya and in proximal portions of dendrites
• mice >12 months of age show hyperphosphorylation and pathological tau phosphorylation, formation of neurofibrillary tangle-like inclusions, tau filaments and ghost tangles (Alzheimer disease-like pathology)
• at 6 months of age, neurons containing tau deposits are detected in the pyramidal cell layer of the CA1 region and in the prefrontal cortex; number increases with age, and by 12 months, such neurons are found in the dentate gyrus, CA3 region, and amygdala
• increase in number of glial cells is detected in hippocampal hilus, cerebral cortex, corpus callosum, CA1, and CA3 region in aged mice
• neurons containing pathological tau species increases with age
• synaptic function (transmission) is decreased by 80% relative to wild-type
• synaptic excitability is reduced in 14-15 month animals; mean amplitude of EPSPs at high stimulation intensity is 0.289 mV vs 1.24 mV in wild-type mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:111982




Genotype
MGI:5521287
tg2
Allelic
Composition
Tg(Thy1-MAPT)22Schd/0
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• 12 month old mutants exhibit hyperactivity during the dark phase of the cycle
• 12 month old mutants exhibit increased agitation in home cage activity during the initial exploration/introduction phase
• in the tube test of aggression and dominance, 12 month old mutants repeatedly push the opponent mouse out of the tube, resulting in more wins and indicating increased aggression
• food-rewarded operant conditioning nosepokes are lower in 12 month old mutants than wild-type mice in variable interval trials
• in the tail suspension test, 12 month old mutants struggle less vigorously and show longer times of total immobility, indicating increased depression-like behaviors
• 12 month old mutants exhibit hyperactivity during the dark phase of the cycle

homeostasis/metabolism
• hippocampal 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) levels are lower in 12 month old mutants than in wild-type

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:197067





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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory