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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
tnyw
tiny wasting
MGI:3717082
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Pemttm1J/Pemttm1J
tnyw/tnyw
B6;129P2 Pemttm1J-tnyw/GrsrJ MGI:3723603


Genotype
MGI:3723603
cx1
Allelic
Composition
Pemttm1J/Pemttm1J
tnyw/tnyw
Genetic
Background
B6;129P2 Pemttm1J-tnyw/GrsrJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pemttm1J mutation (2 available); any Pemt mutation (10 available)
tnyw mutation (1 available); any tnyw mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Small size of Pemttm1J/Pemttm1J tnyw/tnyw mice (left) with littermate control (right) at 2 weeks of age

mortality/aging
• most tiny wasting homozygotes die by 3 weeks of age

nervous system
• tiny wasting homozygotes assessed at 16 days of age to 3.5 weeks of age display vacuoles in the brain

growth/size/body
• all tiny wasting homozygotes are smaller than heterozygous controls and can be identified by 2 weeks of age by their smaller wasting bodies

behavior/neurological
• some tiny wasting homozygotes are unable to right themselves
• some tiny wasting homozygotes display abnormal locomotion

hearing/vestibular/ear
N
• ABR assessment on 2 tiny wasting homozygotes failed to detect any abnormality

endocrine/exocrine glands
N
• histology of pituitary glands, thyroid glands, and somatic organs reveals no abnormalities





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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory