Mouse Genome Informatics
cn1
     Isl1tm1(cre)Tmj/Isl1+
Shc1tm9Paw/Shc1tm9Paw
involves: 129S1/Sv * 129X1/SvJ
Key:
♀ phenotype observed in females WTSI Wellcome Trust Sanger Institute
♂ phenotype observed in males Euro Europhenome
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:122927 )
• mutants appear normal


Mouse Genome Informatics
cn2
     Isl1tm1(cre)Tmj/Isl1+
Shc1tm9Paw/Shc1tm9.1Paw
involves: 129S1/Sv * 129X1/SvJ
Key:
♀ phenotype observed in females WTSI Wellcome Trust Sanger Institute
♂ phenotype observed in males Euro Europhenome
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:122927 )
• mutants appear normal


Mouse Genome Informatics
cn3
     Myl1tm1(cre)Sjb/Myl1+
Shc1tm9Paw/Shc1tm9Paw
involves: 129S1/Sv * 129X1/SvJ
Key:
♀ phenotype observed in females WTSI Wellcome Trust Sanger Institute
♂ phenotype observed in males Euro Europhenome
N normal phenotype
behavior/neurological
abnormal locomotor coordination ( J:122927 )
• all viable mice are severely uncoordinated, appearing similar to Shc1tm4Paw homozygotes

nervous system
decreased muscle spindle number ( J:122927 )
• between P22 and P35, muscle spindle numbers are reduced 50% compared to controls
• intrafusal fiber numbers are 59% that of controls

muscle
decreased muscle spindle number ( J:122927 )
• between P22 and P35, muscle spindle numbers are reduced 50% compared to controls
• intrafusal fiber numbers are 59% that of controls


Mouse Genome Informatics
cn4
     Myl1tm1(cre)Sjb/Myl1+
Shc1tm3Paw/Shc1tm9Paw
involves: 129S1/Sv * 129X1/SvJ
Key:
♀ phenotype observed in females WTSI Wellcome Trust Sanger Institute
♂ phenotype observed in males Euro Europhenome
N normal phenotype
behavior/neurological
abnormal locomotor coordination ( J:122927 )
• motor abnormalities are similar to those observed in Shc1tm7Paw homozygotes

nervous system
decreased muscle spindle number ( J:122927 )
• between P22 and P35, muscle spindle and intrafusal fiber numbers are reduced compared to controls

muscle
decreased muscle spindle number ( J:122927 )
• between P22 and P35, muscle spindle and intrafusal fiber numbers are reduced compared to controls


Mouse Genome Informatics
cn5
     Myl1tm1(cre)Sjb/Myl1+
Shc1tm4Paw/Shc1tm9Paw
involves: 129S1/Sv * 129X1/SvJ
Key:
♀ phenotype observed in females WTSI Wellcome Trust Sanger Institute
♂ phenotype observed in males Euro Europhenome
N normal phenotype
behavior/neurological
abnormal locomotor coordination ( J:122927 )
• motor abnormalities are less severe, similar to those observed in Shc1tm4Paw homozygotes

muscle
abnormal muscle spindle morphology ( J:122927 )
• between P22 and P35, intrafusal fiber numbers are reduced compared to controls

nervous system
abnormal muscle spindle morphology ( J:122927 )
• between P22 and P35, intrafusal fiber numbers are reduced compared to controls


Mouse Genome Informatics
cn6
     Myl1tm1(cre)Sjb/Myl1+
Shc1tm7Paw/Shc1tm9Paw
involves: 129S1/Sv * 129X1/SvJ
Key:
♀ phenotype observed in females WTSI Wellcome Trust Sanger Institute
♂ phenotype observed in males Euro Europhenome
N normal phenotype
behavior/neurological
abnormal locomotor coordination ( J:122927 )
• motor abnormalities are similar to those observed in Shc1tm7Paw homozygotes

muscle
decreased muscle spindle number ( J:122927 )
• between P22 and P35, muscle spindle and intrafusal fiber numbers are reduced compared to controls

nervous system
decreased muscle spindle number ( J:122927 )
• between P22 and P35, muscle spindle and intrafusal fiber numbers are reduced compared to controls


Mouse Genome Informatics
cn7
     Shc1tm9Paw/Shc1tm9Paw
Tg(MMTV-Erbb2*,-cre)1Mul/0
involves: 129S1/Sv * 129X1/SvJ * FVB/N
Key:
♀ phenotype observed in females WTSI Wellcome Trust Sanger Institute
♂ phenotype observed in males Euro Europhenome
N normal phenotype
tumorigenesis
tumorigenesis ( J:133325 )
N
• mammary tumor development is completely ablated (J:133325)

reproductive system
reproductive system phenotype ( J:133325 )
N
• mammary glands show no hyperplastic or neoplastic lesions within mammary epithelial cells mammary glands show no hyperplastic or neoplastic lesions within mammary epithelial cells (J:133325)

endocrine/exocrine glands
abnormal mammary gland morphology ( J:133325 )
• compared to wild-type FVB controls, proliferative index of mammary epithelial cells is strongly reduced and apoptotic index is significantly increased (J:133325)

integument
abnormal mammary gland morphology ( J:133325 )
• compared to wild-type FVB controls, proliferative index of mammary epithelial cells is strongly reduced and apoptotic index is significantly increased (J:133325)