Mouse Genome Informatics
cn1
    Isl1tm1(cre)Tmj/Isl1+
Shc1tm9Paw/Shc1tm9Paw

involves: 129S1/Sv * 129X1/SvJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
normal phenotype
• mutants appear normal


Mouse Genome Informatics
cn2
    Isl1tm1(cre)Tmj/Isl1+
Shc1tm9Paw/Shc1tm9.1Paw

involves: 129S1/Sv * 129X1/SvJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
normal phenotype
• mutants appear normal


Mouse Genome Informatics
cn3
    Myl1tm1(cre)Sjb/Myl1+
Shc1tm9Paw/Shc1tm9Paw

involves: 129S1/Sv * 129X1/SvJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
behavior/neurological
• all viable mice are severely uncoordinated, appearing similar to Shc1tm4Paw homozygotes

nervous system
• between P22 and P35, muscle spindle numbers are reduced 50% compared to controls
• intrafusal fiber numbers are 59% that of controls

muscle
• between P22 and P35, muscle spindle numbers are reduced 50% compared to controls
• intrafusal fiber numbers are 59% that of controls


Mouse Genome Informatics
cn4
    Myl1tm1(cre)Sjb/Myl1+
Shc1tm3Paw/Shc1tm9Paw

involves: 129S1/Sv * 129X1/SvJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
behavior/neurological
• motor abnormalities are similar to those observed in Shc1tm7Paw homozygotes

nervous system
• between P22 and P35, muscle spindle and intrafusal fiber numbers are reduced compared to controls

muscle
• between P22 and P35, muscle spindle and intrafusal fiber numbers are reduced compared to controls


Mouse Genome Informatics
cn5
    Myl1tm1(cre)Sjb/Myl1+
Shc1tm4Paw/Shc1tm9Paw

involves: 129S1/Sv * 129X1/SvJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
behavior/neurological
• motor abnormalities are less severe, similar to those observed in Shc1tm4Paw homozygotes

muscle
• between P22 and P35, intrafusal fiber numbers are reduced compared to controls

nervous system
• between P22 and P35, intrafusal fiber numbers are reduced compared to controls


Mouse Genome Informatics
cn6
    Myl1tm1(cre)Sjb/Myl1+
Shc1tm7Paw/Shc1tm9Paw

involves: 129S1/Sv * 129X1/SvJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
behavior/neurological
• motor abnormalities are similar to those observed in Shc1tm7Paw homozygotes

muscle
• between P22 and P35, muscle spindle and intrafusal fiber numbers are reduced compared to controls

nervous system
• between P22 and P35, muscle spindle and intrafusal fiber numbers are reduced compared to controls


Mouse Genome Informatics
cn7
    Shc1tm9Paw/Shc1tm9Paw
Tg(MMTV-Erbb2*,-cre)1Mul/0

involves: 129S1/Sv * 129X1/SvJ * FVB/N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
tumorigenesis
N
• mammary tumor development is completely ablated (J:133325)

reproductive system
N
• mammary glands show no hyperplastic or neoplastic lesions within mammary epithelial cells mammary glands show no hyperplastic or neoplastic lesions within mammary epithelial cells (J:133325)

endocrine/exocrine glands
• compared to wild-type FVB controls, proliferative index of mammary epithelial cells is strongly reduced and apoptotic index is significantly increased (J:133325)

integument
• compared to wild-type FVB controls, proliferative index of mammary epithelial cells is strongly reduced and apoptotic index is significantly increased (J:133325)