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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Shc1tm9Paw
targeted mutation 9, Tony Pawson
MGI:3716783
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Isl1tm1(cre)Tmj/Isl1+
Shc1tm9Paw/Shc1tm9Paw
involves: 129S1/Sv * 129X1/SvJ MGI:3717100
cn2
Isl1tm1(cre)Tmj/Isl1+
Shc1tm9Paw/Shc1tm9.1Paw
involves: 129S1/Sv * 129X1/SvJ MGI:3717101
cn3
Myl1tm1(cre)Sjb/Myl1+
Shc1tm9Paw/Shc1tm9Paw
involves: 129S1/Sv * 129X1/SvJ MGI:3717102
cn4
Myl1tm1(cre)Sjb/Myl1+
Shc1tm3Paw/Shc1tm9Paw
involves: 129S1/Sv * 129X1/SvJ MGI:3717104
cn5
Myl1tm1(cre)Sjb/Myl1+
Shc1tm4Paw/Shc1tm9Paw
involves: 129S1/Sv * 129X1/SvJ MGI:3717105
cn6
Myl1tm1(cre)Sjb/Myl1+
Shc1tm7Paw/Shc1tm9Paw
involves: 129S1/Sv * 129X1/SvJ MGI:3717106
cn7
Shc1tm9Paw/Shc1tm9Paw
Tg(MMTV-Erbb2*,-cre)1Mul/0
involves: 129S1/Sv * 129X1/SvJ * FVB/N MGI:4361923


Genotype
MGI:3717100
cn1
Allelic
Composition
Isl1tm1(cre)Tmj/Isl1+
Shc1tm9Paw/Shc1tm9Paw
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Isl1tm1(cre)Tmj mutation (1 available); any Isl1 mutation (14 available)
Shc1tm9Paw mutation (0 available); any Shc1 mutation (54 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mutants appear normal




Genotype
MGI:3717101
cn2
Allelic
Composition
Isl1tm1(cre)Tmj/Isl1+
Shc1tm9Paw/Shc1tm9.1Paw
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Isl1tm1(cre)Tmj mutation (1 available); any Isl1 mutation (14 available)
Shc1tm9.1Paw mutation (0 available); any Shc1 mutation (54 available)
Shc1tm9Paw mutation (0 available); any Shc1 mutation (54 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mutants appear normal




Genotype
MGI:3717102
cn3
Allelic
Composition
Myl1tm1(cre)Sjb/Myl1+
Shc1tm9Paw/Shc1tm9Paw
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myl1tm1(cre)Sjb mutation (1 available); any Myl1 mutation (5 available)
Shc1tm9Paw mutation (0 available); any Shc1 mutation (54 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• all viable mice are severely uncoordinated, appearing similar to Shc1tm4Paw homozygotes

nervous system
• between P22 and P35, muscle spindle numbers are reduced 50% compared to controls
• intrafusal fiber numbers are 59% that of controls

muscle
• between P22 and P35, muscle spindle numbers are reduced 50% compared to controls
• intrafusal fiber numbers are 59% that of controls




Genotype
MGI:3717104
cn4
Allelic
Composition
Myl1tm1(cre)Sjb/Myl1+
Shc1tm3Paw/Shc1tm9Paw
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myl1tm1(cre)Sjb mutation (1 available); any Myl1 mutation (5 available)
Shc1tm3Paw mutation (0 available); any Shc1 mutation (54 available)
Shc1tm9Paw mutation (0 available); any Shc1 mutation (54 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• motor abnormalities are similar to those observed in Shc1tm7Paw homozygotes

nervous system
• between P22 and P35, muscle spindle and intrafusal fiber numbers are reduced compared to controls

muscle
• between P22 and P35, muscle spindle and intrafusal fiber numbers are reduced compared to controls




Genotype
MGI:3717105
cn5
Allelic
Composition
Myl1tm1(cre)Sjb/Myl1+
Shc1tm4Paw/Shc1tm9Paw
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myl1tm1(cre)Sjb mutation (1 available); any Myl1 mutation (5 available)
Shc1tm4Paw mutation (0 available); any Shc1 mutation (54 available)
Shc1tm9Paw mutation (0 available); any Shc1 mutation (54 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• motor abnormalities are less severe, similar to those observed in Shc1tm4Paw homozygotes

muscle
• between P22 and P35, intrafusal fiber numbers are reduced compared to controls

nervous system
• between P22 and P35, intrafusal fiber numbers are reduced compared to controls




Genotype
MGI:3717106
cn6
Allelic
Composition
Myl1tm1(cre)Sjb/Myl1+
Shc1tm7Paw/Shc1tm9Paw
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myl1tm1(cre)Sjb mutation (1 available); any Myl1 mutation (5 available)
Shc1tm7Paw mutation (0 available); any Shc1 mutation (54 available)
Shc1tm9Paw mutation (0 available); any Shc1 mutation (54 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• motor abnormalities are similar to those observed in Shc1tm7Paw homozygotes

muscle
• between P22 and P35, muscle spindle and intrafusal fiber numbers are reduced compared to controls

nervous system
• between P22 and P35, muscle spindle and intrafusal fiber numbers are reduced compared to controls




Genotype
MGI:4361923
cn7
Allelic
Composition
Shc1tm9Paw/Shc1tm9Paw
Tg(MMTV-Erbb2*,-cre)1Mul/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shc1tm9Paw mutation (0 available); any Shc1 mutation (54 available)
Tg(MMTV-Erbb2*,-cre)1Mul mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
N
• mammary tumor development is completely ablated

reproductive system
N
• mammary glands show no hyperplastic or neoplastic lesions within mammary epithelial cells mammary glands show no hyperplastic or neoplastic lesions within mammary epithelial cells

endocrine/exocrine glands
• compared to wild-type FVB controls, proliferative index of mammary epithelial cells is strongly reduced and apoptotic index is significantly increased

integument
• compared to wild-type FVB controls, proliferative index of mammary epithelial cells is strongly reduced and apoptotic index is significantly increased





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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory