All Phenotypes Shc1<tm7Paw> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Shc1^tm7Paw
targeted mutation 7, Tony Pawson
MGI:3716781

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Shc1^tm7Paw/Shc1^tm7Paw	involves: 129S1/Sv * 129X1/SvJ	MGI:3717094
ht2	Shc1^tm3Paw/Shc1^tm7Paw	involves: 129S1/Sv * 129X1/SvJ	MGI:3717108
cn3	Myl1^tm1(cre)Sjb/Myl1⁺ Shc1^tm7Paw/Shc1^tm9Paw	involves: 129S1/Sv * 129X1/SvJ	MGI:3717106
cx4	Shc1^tm7Paw/Shc1⁺ Tg(MMTV-PyVT)634Mul/0	involves: 129S1/Sv * 129X1/SvJ * FVB/N	MGI:4361926

Allelic Composition	Shc1^tm7Paw/Shc1^tm7Paw
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shc1^tm7Paw mutation (0 available); any Shc1 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality ( J:122927 )

behavior/neurological

abnormal locomotor coordination ( J:122927 )

ataxia ( J:122927 )

impaired limb coordination ( J:122927 )

muscle

abnormal muscle spindle morphology ( J:122927 )

nervous system

abnormal muscle spindle morphology ( J:122927 )

abnormal motor neuron morphology ( J:122927 )

abnormal nerve conduction ( J:122927 )

abnormal excitatory postsynaptic potential ( J:122927 )

Allelic Composition	Shc1^tm3Paw/Shc1^tm7Paw
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shc1^tm3Paw mutation (0 available); any Shc1 mutation (66 available)
Shc1^tm7Paw mutation (0 available); any Shc1 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal locomotor coordination ( J:122927 )

• mice display motor defects more severe than than transheterozygous Shc1^{tm3Paw/tm4Paw} mice

nervous system

decreased muscle spindle number ( J:122927 )

• between P22 and P35, muscle spindles are abnormal and numbers are 13% of controls

• intrafusal fiber numbers are 35.9% of control numbers

muscle

decreased muscle spindle number ( J:122927 )

• between P22 and P35, muscle spindles are abnormal and numbers are 13% of controls

• intrafusal fiber numbers are 35.9% of control numbers

Allelic Composition	Myl1^tm1(cre)Sjb/Myl1⁺ Shc1^tm7Paw/Shc1^tm9Paw
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myl1^tm1(cre)Sjb mutation (2 available); any Myl1 mutation (17 available)
Shc1^tm7Paw mutation (0 available); any Shc1 mutation (66 available)
Shc1^tm9Paw mutation (0 available); any Shc1 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal locomotor coordination ( J:122927 )

• motor abnormalities are similar to those observed in Shc1^tm7Paw homozygotes

ataxia ( J:122927 )

impaired limb coordination ( J:122927 )

muscle

decreased muscle spindle number ( J:122927 )

• between P22 and P35, muscle spindle and intrafusal fiber numbers are reduced compared to controls

nervous system

decreased muscle spindle number ( J:122927 )

• between P22 and P35, muscle spindle and intrafusal fiber numbers are reduced compared to controls

Allelic Composition	Shc1^tm7Paw/Shc1⁺ Tg(MMTV-PyVT)634Mul/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shc1^tm7Paw mutation (0 available); any Shc1 mutation (66 available)
Tg(MMTV-PyVT)634Mul mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:133325 )

• glands contain combination of tumor and hyperplastic structures

• combination of adenomas and cystic hyperplasias are seen in mammary glands

• tumor angiogenesis is decreased relative to tumors from Tg(MMTV-PyVT)634Mul single mutants

decreased metastatic potential ( J:133325 )

• number of mice displaying lung metastases is decreased compared to Tg(MMTV-PyVT)634Mul single mutants (60 vs 91 mice)

increased tumor latency ( J:133325 )

• mammary tumor latency is strongly increased compared to Tg(MMTV-PyVT)634Mul single mutants (95 days vs 66 days)

endocrine/exocrine glands

abnormal mammary gland morphology ( J:133325 )

• glands contain combination of tumor and hyperplastic structures

increased mammary gland tumor incidence ( J:133325 )

• glands contain combination of tumor and hyperplastic structures

• combination of adenomas and cystic hyperplasias are seen in mammary glands

• tumor angiogenesis is decreased relative to tumors from Tg(MMTV-PyVT)634Mul single mutants

integument

abnormal mammary gland morphology ( J:133325 )

• glands contain combination of tumor and hyperplastic structures

increased mammary gland tumor incidence ( J:133325 )

• glands contain combination of tumor and hyperplastic structures

• combination of adenomas and cystic hyperplasias are seen in mammary glands

• tumor angiogenesis is decreased relative to tumors from Tg(MMTV-PyVT)634Mul single mutants

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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