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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Artm1.1Jdz
targeted mutation 1.1, Jeffrey D Zajac
MGI:3716756
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ot1
Artm1.1Jdz/Y B6.129X1-Artm1.1Jdz MGI:3717244
ot2
Artm1.1Jdz/Y involves: 129X1/SvJ * C57BL/6 MGI:3717256


Genotype
MGI:3717244
ot1
Allelic
Composition
Artm1.1Jdz/Y
Genetic
Background
B6.129X1-Artm1.1Jdz
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Artm1.1Jdz mutation (0 available); any Ar mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• at 8 weeks, hemizygous mutant males show a marked reduction of the total number of germ cells in their seminiferous tubules, although the number of spermatogonia is apparently normal (J:123057)
• at 8 weeks, hemizygous mutant males show a marked reduction of the total number of germ cells in their seminiferous tubules, although the number of spermatogonia is apparently normal (J:123057)
• no spermatozoa are detected at 8 weeks of age (J:123057)
• no spermatozoa are detected at 8 weeks of age (J:123057)
• at 8 weeks, spermatogenesis is incomplete, as primary spermatocytes are readily observed, but no secondary spermatocytes, spermatids or spermatozoa are detected (J:123057)
• at 8 weeks, spermatogenesis is incomplete, as primary spermatocytes are readily observed, but no secondary spermatocytes, spermatids or spermatozoa are detected (J:123057)
• spermatogenesis is arrested at meiosis I (J:123057)
• spermatogenesis is arrested at meiosis I (J:123057)
• at 8 weeks of age (J:123057)
• at 8 weeks of age (J:123057)
• at 8 weeks of age (J:123057)
• at 8 weeks of age (J:123057)
• at 8 weeks of age, the tunica propria is more prominent in the mutant testis with 2-3 layers visible relative to one layer found in wild-type males (J:123057)
• although Leydig cells are present in similar numbers to those found in wild-type testes, the interstitial connective tissue appears to be more pronounced in mutant testes (J:123057)
• at 8 weeks of age, the tunica propria is more prominent in the mutant testis with 2-3 layers visible relative to one layer found in wild-type males (J:123057)
• although Leydig cells are present in similar numbers to those found in wild-type testes, the interstitial connective tissue appears to be more pronounced in mutant testes (J:123057)
• at 8 weeks, the seminiferous tubules in mutant testis are smaller in diameter relative to wild-type controls (J:123057)
• at 8 weeks, the seminiferous tubules in mutant testis are smaller in diameter relative to wild-type controls (J:123057)
• at 8 weeks of age, mutant testes are smaller than wild-type (J:123057)
• at 8 weeks of age, mutant testes are smaller than wild-type (J:123057)
• at 8 weeks of age, the testis mass of hemizygous mutant males is reduced by 95% relative to wild-type control males (J:123057)
• at 8 weeks of age, the testis mass of hemizygous mutant males is reduced by 95% relative to wild-type control males (J:123057)
• mutant testes are located intra-abdominally (J:123057)
• mutant testes are located intra-abdominally (J:123057)
• hemizygous mutant males display female external genitalia (J:123057)
• hemizygous mutant males display female external genitalia (J:123057)

growth/size/body
• at 8 weeks and 10 to 25 weeks hemizygous mutant males weigh less than wild-type males; their mean body weight is intermediate between wild-type male and female control littermates (J:123057)
• contrary to expectation, hemizygous mutant males do not become heavier than wild-type control males with increasing age (J:123057)
• at 8 weeks and 10 to 25 weeks hemizygous mutant males weigh less than wild-type males; their mean body weight is intermediate between wild-type male and female control littermates (J:123057)
• contrary to expectation, hemizygous mutant males do not become heavier than wild-type control males with increasing age (J:123057)

homeostasis/metabolism
• at 9 weeks of age, serum testosterone levels of hemizygous mutant males are reduced relative to wild-type control littermates (J:123057)
• at 9 weeks of age, serum testosterone levels of hemizygous mutant males are reduced relative to wild-type control littermates (J:123057)

endocrine/exocrine glands
• at 8 weeks of age (J:123057)
• at 8 weeks of age (J:123057)
• at 8 weeks of age (J:123057)
• at 8 weeks of age (J:123057)
• at 8 weeks of age, the tunica propria is more prominent in the mutant testis with 2-3 layers visible relative to one layer found in wild-type males (J:123057)
• although Leydig cells are present in similar numbers to those found in wild-type testes, the interstitial connective tissue appears to be more pronounced in mutant testes (J:123057)
• at 8 weeks of age, the tunica propria is more prominent in the mutant testis with 2-3 layers visible relative to one layer found in wild-type males (J:123057)
• although Leydig cells are present in similar numbers to those found in wild-type testes, the interstitial connective tissue appears to be more pronounced in mutant testes (J:123057)
• at 8 weeks, the seminiferous tubules in mutant testis are smaller in diameter relative to wild-type controls (J:123057)
• at 8 weeks, the seminiferous tubules in mutant testis are smaller in diameter relative to wild-type controls (J:123057)
• at 8 weeks of age, mutant testes are smaller than wild-type (J:123057)
• at 8 weeks of age, mutant testes are smaller than wild-type (J:123057)
• at 8 weeks of age, the testis mass of hemizygous mutant males is reduced by 95% relative to wild-type control males (J:123057)
• at 8 weeks of age, the testis mass of hemizygous mutant males is reduced by 95% relative to wild-type control males (J:123057)
• mutant testes are located intra-abdominally (J:123057)
• mutant testes are located intra-abdominally (J:123057)

Mouse Models of Human Disease
OMIM ID Ref(s)
Androgen Insensitivity Syndrome; AIS 300068 J:123057




Genotype
MGI:3717256
ot2
Allelic
Composition
Artm1.1Jdz/Y
Genetic
Background
involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Artm1.1Jdz mutation (0 available); any Ar mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• short ano-genital distance at 8 weeks of age (J:122327)
• short ano-genital distance at 8 weeks of age (J:122327)
(J:122327)
(J:122327)
(J:122327)
(J:122327)
• immature testes at 8 weeks of age (J:122327)
• immature testes at 8 weeks of age (J:122327)
• at 8 weeks of age, testis weight is reduced by 95% compared to wild-type mice (J:122327)
• at 8 weeks of age, testis weight is reduced by 95% compared to wild-type mice (J:122327)
• testes are incompletely descended (J:122327)
• testes are incompletely descended (J:122327)
(J:122327)
(J:122327)
(J:122327)
(J:122327)

homeostasis/metabolism
• at 8 weeks of age, serum testosterone is reduced by 75% compared to in wild-type mice (J:122327)
• at 8 weeks of age, serum testosterone is reduced by 75% compared to in wild-type mice (J:122327)

digestive/alimentary system
• short ano-genital distance at 8 weeks of age (J:122327)
• short ano-genital distance at 8 weeks of age (J:122327)

endocrine/exocrine glands
(J:122327)
(J:122327)
(J:122327)
(J:122327)
• immature testes at 8 weeks of age (J:122327)
• immature testes at 8 weeks of age (J:122327)
• at 8 weeks of age, testis weight is reduced by 95% compared to wild-type mice (J:122327)
• at 8 weeks of age, testis weight is reduced by 95% compared to wild-type mice (J:122327)
• testes are incompletely descended (J:122327)
• testes are incompletely descended (J:122327)

growth/size/body
N
• at 8 weeks of age, mutant males are overtly healthy with normal physical activity and normal body weights relative to control littermates (J:122327)
• at 8 weeks of age, mutant males are overtly healthy with normal physical activity and normal body weights relative to control littermates (J:122327)

Mouse Models of Human Disease
OMIM ID Ref(s)
Androgen Insensitivity Syndrome; AIS 300068 J:122327





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory