Mouse Genome Informatics
ot1
    Artm1.1Jdz/Y
B6.129X1-Artm1.1Jdz
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
reproductive system
• at 8 weeks, hemizygous mutant males show a marked reduction of the total number of germ cells in their seminiferous tubules, although the number of spermatogonia is apparently normal
• no spermatozoa are detected at 8 weeks of age
• at 8 weeks, spermatogenesis is incomplete, as primary spermatocytes are readily observed, but no secondary spermatocytes, spermatids or spermatozoa are detected
• spermatogenesis is arrested at meiosis I
• at 8 weeks of age
• at 8 weeks of age
• at 8 weeks of age, the tunica propria is more prominent in the mutant testis with 2-3 layers visible relative to one layer found in wild-type males
• although Leydig cells are present in similar numbers to those found in wild-type testes, the interstitial connective tissue appears to be more pronounced in mutant testes
• at 8 weeks, the seminiferous tubules in mutant testis are smaller in diameter relative to wild-type controls
• at 8 weeks of age, mutant testes are smaller than wild-type
• at 8 weeks of age, the testis mass of hemizygous mutant males is reduced by 95% relative to wild-type control males
• mutant testes are located intra-abdominally
• hemizygous mutant males display female external genitalia

growth/size/body
• at 8 weeks and 10 to 25 weeks hemizygous mutant males weigh less than wild-type males; their mean body weight is intermediate between wild-type male and female control littermates
• contrary to expectation, hemizygous mutant males do not become heavier than wild-type control males with increasing age

homeostasis/metabolism
• at 9 weeks of age, serum testosterone levels of hemizygous mutant males are reduced relative to wild-type control littermates

endocrine/exocrine glands
• at 8 weeks of age
• at 8 weeks of age
• at 8 weeks of age, the tunica propria is more prominent in the mutant testis with 2-3 layers visible relative to one layer found in wild-type males
• although Leydig cells are present in similar numbers to those found in wild-type testes, the interstitial connective tissue appears to be more pronounced in mutant testes
• at 8 weeks, the seminiferous tubules in mutant testis are smaller in diameter relative to wild-type controls
• at 8 weeks of age, mutant testes are smaller than wild-type
• at 8 weeks of age, the testis mass of hemizygous mutant males is reduced by 95% relative to wild-type control males
• mutant testes are located intra-abdominally

Mouse Models of Human Disease
OMIM IDRef(s)
Androgen Insensitivity Syndrome; AIS 300068 J:123057


Mouse Genome Informatics
ot2
    Artm1.1Jdz/Y
involves: 129X1/SvJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
reproductive system
• short ano-genital distance at 8 weeks of age (J:122327)
• immature testes at 8 weeks of age (J:122327)
• at 8 weeks of age, testis weight is reduced by 95% compared to wild-type mice (J:122327)
• testes are incompletely descended (J:122327)
(J:122327)

homeostasis/metabolism
• at 8 weeks of age, serum testosterone is reduced by 75% compared to in wild-type mice (J:122327)

digestive/alimentary system
• short ano-genital distance at 8 weeks of age (J:122327)

endocrine/exocrine glands
• immature testes at 8 weeks of age (J:122327)
• at 8 weeks of age, testis weight is reduced by 95% compared to wild-type mice (J:122327)
• testes are incompletely descended (J:122327)

growth/size/body
N
• at 8 weeks of age, mutant males are overtly healthy with normal physical activity and normal body weights relative to control littermates (J:122327)

Mouse Models of Human Disease
OMIM IDRef(s)
Androgen Insensitivity Syndrome; AIS 300068 J:122327