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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Artm1.1Jdz
targeted mutation 1.1, Jeffrey D Zajac
MGI:3716756
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ot1
Artm1.1Jdz/Y B6.129X1-Artm1.1Jdz MGI:3717244
ot2
Artm1.1Jdz/Y involves: 129X1/SvJ * C57BL/6 MGI:3717256


Genotype
MGI:3717244
ot1
Allelic
Composition
Artm1.1Jdz/Y
Genetic
Background
B6.129X1-Artm1.1Jdz
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Artm1.1Jdz mutation (0 available); any Ar mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• at 8 weeks, hemizygous mutant males show a marked reduction of the total number of germ cells in their seminiferous tubules, although the number of spermatogonia is apparently normal
• no spermatozoa are detected at 8 weeks of age
• at 8 weeks, spermatogenesis is incomplete, as primary spermatocytes are readily observed, but no secondary spermatocytes, spermatids or spermatozoa are detected
• spermatogenesis is arrested at meiosis I
• at 8 weeks of age
• at 8 weeks of age
• at 8 weeks of age, the tunica propria is more prominent in the mutant testis with 2-3 layers visible relative to one layer found in wild-type males
• although Leydig cells are present in similar numbers to those found in wild-type testes, the interstitial connective tissue appears to be more pronounced in mutant testes
• at 8 weeks, the seminiferous tubules in mutant testis are smaller in diameter relative to wild-type controls
• at 8 weeks of age, mutant testes are smaller than wild-type
• at 8 weeks of age, the testis mass of hemizygous mutant males is reduced by 95% relative to wild-type control males
• mutant testes are located intra-abdominally
• hemizygous mutant males display female external genitalia

growth/size/body
• at 8 weeks and 10 to 25 weeks hemizygous mutant males weigh less than wild-type males; their mean body weight is intermediate between wild-type male and female control littermates
• contrary to expectation, hemizygous mutant males do not become heavier than wild-type control males with increasing age

homeostasis/metabolism
• at 9 weeks of age, serum testosterone levels of hemizygous mutant males are reduced relative to wild-type control littermates

endocrine/exocrine glands
• at 8 weeks of age
• at 8 weeks of age
• at 8 weeks of age, the tunica propria is more prominent in the mutant testis with 2-3 layers visible relative to one layer found in wild-type males
• although Leydig cells are present in similar numbers to those found in wild-type testes, the interstitial connective tissue appears to be more pronounced in mutant testes
• at 8 weeks, the seminiferous tubules in mutant testis are smaller in diameter relative to wild-type controls
• at 8 weeks of age, mutant testes are smaller than wild-type
• at 8 weeks of age, the testis mass of hemizygous mutant males is reduced by 95% relative to wild-type control males
• mutant testes are located intra-abdominally

Mouse Models of Human Disease
OMIM ID Ref(s)
Androgen Insensitivity Syndrome; AIS 300068 J:123057




Genotype
MGI:3717256
ot2
Allelic
Composition
Artm1.1Jdz/Y
Genetic
Background
involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Artm1.1Jdz mutation (0 available); any Ar mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• short ano-genital distance at 8 weeks of age
• immature testes at 8 weeks of age
• at 8 weeks of age, testis weight is reduced by 95% compared to wild-type mice
• testes are incompletely descended

homeostasis/metabolism
• at 8 weeks of age, serum testosterone is reduced by 75% compared to in wild-type mice

digestive/alimentary system
• short ano-genital distance at 8 weeks of age

endocrine/exocrine glands
• immature testes at 8 weeks of age
• at 8 weeks of age, testis weight is reduced by 95% compared to wild-type mice
• testes are incompletely descended

growth/size/body
N
• at 8 weeks of age, mutant males are overtly healthy with normal physical activity and normal body weights relative to control littermates

Mouse Models of Human Disease
OMIM ID Ref(s)
Androgen Insensitivity Syndrome; AIS 300068 J:122327





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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory