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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(AMELX*P70T)2Gibs
transgene insertion 2, Carolyn Gibson
MGI:3716166
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Amelxtm1Kul/Amelxtm1Kul
Tg(AMELX*P70T)2Gibs/?
involves: 129S1/Sv * 129X1/SvJ MGI:5086118
tg2
Tg(AMELX*P70T)2Gibs/? Not Specified MGI:5086116


Genotype
MGI:5086118
cx1
Allelic
Composition
Amelxtm1Kul/Amelxtm1Kul
Tg(AMELX*P70T)2Gibs/?
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amelxtm1Kul mutation (1 available); any Amelx mutation (19 available)
Tg(AMELX*P70T)2Gibs mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• molar enamel has a hyperplastic intermedium cell layer exhibiting transition to tumor cells

neoplasm
• molar enamel has a hyperplastic intermedium cell layer exhibiting transition to tumor cells
• tumor is composed of benign, eosinophilic, polygonal-shaped cells with intercellular bridges
• calcification is not obvious in these tumors

craniofacial
• molar enamel has a hyperplastic intermedium cell layer exhibiting transition to tumor cells

growth/size/body
• molar enamel has a hyperplastic intermedium cell layer exhibiting transition to tumor cells

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
amelogenesis imperfecta type 1E DOID:0110058 OMIM:301200
J:122914




Genotype
MGI:5086116
tg2
Allelic
Composition
Tg(AMELX*P70T)2Gibs/?
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(AMELX*P70T)2Gibs mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• molars have marked attrition of cusps
• molars have irregular chalky appearance
• molars have an irregular, chalky appearance
• molar enamel has aprismatic regions with the porosity and appearance of platelike crystallites
• males exhibit more aprismatic regions than females

craniofacial
• molars have marked attrition of cusps
• molars have irregular chalky appearance
• molars have an irregular, chalky appearance
• molar enamel has aprismatic regions with the porosity and appearance of platelike crystallites
• males exhibit more aprismatic regions than females

growth/size/body
• molars have marked attrition of cusps
• molars have irregular chalky appearance
• molars have an irregular, chalky appearance
• molar enamel has aprismatic regions with the porosity and appearance of platelike crystallites
• males exhibit more aprismatic regions than females

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
amelogenesis imperfecta type 1E DOID:0110058 OMIM:301200
J:122914





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last database update
10/10/2017
MGI 6.10
The Jackson Laboratory