Mouse Genome Informatics
cx1
    Amelxtm1Kul/Amelxtm1Kul
Tg(AMELX*P70T)2Gibs/?

involves: 129S1/Sv * 129X1/SvJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
tumorigenesis
• molar enamel has a hyperplastic intermedium cell layer exhibiting transition to tumor cells (J:122914)
• tumor is composed of benign, eosinophilic, polygonal-shaped cells with intercellular bridges (J:122914)
• calcification is not obvious in these tumors (J:122914)

craniofacial
• molar enamel has a hyperplastic intermedium cell layer exhibiting transition to tumor cells (J:122914)

growth/size
• molar enamel has a hyperplastic intermedium cell layer exhibiting transition to tumor cells (J:122914)

Mouse Models of Human Disease
OMIM IDRef(s)
Amelogenesis Imperfecta, Type IE; AI1E 301200 J:122914


Mouse Genome Informatics
tg2
    Tg(AMELX*P70T)2Gibs/?
Not Specified
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
craniofacial
• molars have marked attrition of cusps
• molars have irregular chalky appearance
• molars have an irregular, chalky appearance
• molar enamel has aprismatic regions with the porosity and appearance of platelike crystallites
• males exhibit more aprismatic regions than females

growth/size
• molars have marked attrition of cusps
• molars have irregular chalky appearance
• molars have an irregular, chalky appearance
• molar enamel has aprismatic regions with the porosity and appearance of platelike crystallites
• males exhibit more aprismatic regions than females

Mouse Models of Human Disease
OMIM IDRef(s)
Amelogenesis Imperfecta, Type IE; AI1E 301200 J:122914