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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(AMELX*P70T)2Gibs
transgene insertion 2, Carolyn Gibson
MGI:3716166
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Amelxtm1Kul/Amelxtm1Kul
Tg(AMELX*P70T)2Gibs/?
involves: 129S1/Sv * 129X1/SvJ MGI:5086118
tg2
Tg(AMELX*P70T)2Gibs/? Not Specified MGI:5086116


Genotype
MGI:5086118
cx1
Allelic
Composition
Amelxtm1Kul/Amelxtm1Kul
Tg(AMELX*P70T)2Gibs/?
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amelxtm1Kul mutation (1 available); any Amelx mutation (17 available)
Tg(AMELX*P70T)2Gibs mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• molar enamel has a hyperplastic intermedium cell layer exhibiting transition to tumor cells

neoplasm
• molar enamel has a hyperplastic intermedium cell layer exhibiting transition to tumor cells
• tumor is composed of benign, eosinophilic, polygonal-shaped cells with intercellular bridges
• calcification is not obvious in these tumors

craniofacial
• molar enamel has a hyperplastic intermedium cell layer exhibiting transition to tumor cells

growth/size/body
• molar enamel has a hyperplastic intermedium cell layer exhibiting transition to tumor cells

Mouse Models of Human Disease
OMIM ID Ref(s)
Amelogenesis Imperfecta, Type IE; AI1E 301200 J:122914




Genotype
MGI:5086116
tg2
Allelic
Composition
Tg(AMELX*P70T)2Gibs/?
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• molars have marked attrition of cusps
• molars have irregular chalky appearance
• molars have an irregular, chalky appearance
• molar enamel has aprismatic regions with the porosity and appearance of platelike crystallites
• males exhibit more aprismatic regions than females

craniofacial
• molars have marked attrition of cusps
• molars have irregular chalky appearance
• molars have an irregular, chalky appearance
• molar enamel has aprismatic regions with the porosity and appearance of platelike crystallites
• males exhibit more aprismatic regions than females

growth/size/body
• molars have marked attrition of cusps
• molars have irregular chalky appearance
• molars have an irregular, chalky appearance
• molar enamel has aprismatic regions with the porosity and appearance of platelike crystallites
• males exhibit more aprismatic regions than females

Mouse Models of Human Disease
OMIM ID Ref(s)
Amelogenesis Imperfecta, Type IE; AI1E 301200 J:122914





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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory