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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Mx1s1
myxovirus susceptibility 1
MGI:3715154
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Mx1s1/Mx1s1 BALB/c MGI:3715183
hm2
Mx1s1/Mx1s1 C3H MGI:3718024
hm3
Mx1s1/Mx1s1 C57BL/6 MGI:3715200
cx4
Mx1s1/Mx1s1
Tg(Hmgcr-MX1)LStae/?
involves: C57BL/6 * SJL MGI:3765443


Genotype
MGI:3715183
hm1
Allelic
Composition
Mx1s1/Mx1s1
Genetic
Background
BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mx1s1 mutation (27 available); any Mx1 mutation (42 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 14 of 16 mice die following infection with Thogoto virus

immune system
• following Thogoto virus infection, titers of 107.5 are detected in 50% of tissues
• following Thogoto virus infection, livers become pale, yellow, swollen, and friable at 72 to 96 hours
• following Thogoto virus infection, cellular degeneration in the liver is characterized by acidophilic hyalinization of the cytoplasm, pyknotic, or karyorrhetic nuclei and the formation of typical Councilman bodies
• following Thogoto virus infection, liver necrosis occurs
• IFN treatment only slightly inhibits or delays Thogoto virus multiplication in embryo cells




Genotype
MGI:3718024
hm2
Allelic
Composition
Mx1s1/Mx1s1
Genetic
Background
C3H
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mx1s1 mutation (27 available); any Mx1 mutation (42 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• following intraperitoneal infection with Thogoto virus, 5 of 5 mice die despite treatment with an interferon inducer, poly(I)-poly(C)




Genotype
MGI:3715200
hm3
Allelic
Composition
Mx1s1/Mx1s1
Genetic
Background
C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mx1s1 mutation (27 available); any Mx1 mutation (42 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• following infection with Thogoto virus, 9 of 10 mice die despite treatment with an interferon inducer, poly(I)-poly(C)
• following intraperitoneal infection with Thogoto virus, 7 of 7 mice die

immune system
• after 96 hours of Thogoto virus infection in culture, peritoneal microphages become round and detach from culture dishes
• LD50 for hvPR8 is about 10 plaque forming units
• IFN treatment is ineffective at decreasing susceptibility to hvPR8
• following infection with Thogoto virus, 9 of 10 mice die despite treatment with an interferon inducer, poly(I)-poly(C)
• following intraperitoneal infection with Thogoto virus, 7 of 7 mice die

hematopoietic system
• after 96 hours of Thogoto virus infection in culture, peritoneal microphages become round and detach from culture dishes




Genotype
MGI:3765443
cx4
Allelic
Composition
Mx1s1/Mx1s1
Tg(Hmgcr-MX1)LStae/?
Genetic
Background
involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mx1s1 mutation (27 available); any Mx1 mutation (42 available)
Tg(Hmgcr-MX1)LStae mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no lethality is observed in mice challenged with Thogoto virus while all the littermate controls died
• decreased lethality is observed in mice challenged with influenza A virus or VSV
• mice infected with influenza A virus by an intracerebal route have longer mean survival times (6.0 days vs. 3.9)
• mice infected with VSV by an intracerebal route have longer mean survival times (2.7 days vs. 1.5)
• mice infected with pneumotropic influenza A virus have increased rates of survival (33.3% vs 0%) for wild-type controls

immune system
• supernatant of embryonic fibroblasts infected with influenza A virus or VSV contains 10-40 fold less infectious particles 25 hours after infection
• supernatant of embryonic fibroblasts infected with Thogoto virus contains no infectious particles 3 days after infection
• no lethality is observed in mice challenged with Thogoto virus while all the littermate controls died
• decreased lethality is observed in mice challenged with influenza A virus or VSV
• mice infected with influenza A virus by an intracerebal route have longer mean survival times (6.0 days vs. 3.9)
• mice infected with VSV by an intracerebal route have longer mean survival times (2.7 days vs. 1.5)
• mice infected with pneumotropic influenza A virus have increased rates of survival (33.3% vs 0%) for wild-type controls





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory