Phenotypes associated with this allele

• Allele Symbol: Mx1^s1
• Allele Name: myxovirus susceptibility 1
• Allele ID: MGI:3715154
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mx1^s1/Mx1^s1	BALB/c	MGI:3715183
hm2	Mx1^s1/Mx1^s1	C3H	MGI:3718024
hm3	Mx1^s1/Mx1^s1	C57BL/6	MGI:3715200
cx4	Mx1^s1/Mx1^s1 Tg(Hmgcr-MX1)LStae/?	involves: C57BL/6 * SJL	MGI:3765443

Genotype
MGI:3715183

hm1

• Allelic Composition: Mx1^s1/Mx1^s1
• Genetic Background: BALB/c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:23752 )

• 14 of 16 mice die following infection with Thogoto virus

immune system

increased susceptibility to Orthomyxoviridae infection ( J:23752 )

• following Thogoto virus infection, titers of 10^7.5 are detected in 50% of tissues

• following Thogoto virus infection, livers become pale, yellow, swollen, and friable at 72 to 96 hours

• following Thogoto virus infection, cellular degeneration in the liver is characterized by acidophilic hyalinization of the cytoplasm, pyknotic, or karyorrhetic nuclei and the formation of typical Councilman bodies

• following Thogoto virus infection, liver necrosis occurs

• IFN treatment only slightly inhibits or delays Thogoto virus multiplication in embryo cells

Genotype
MGI:3718024

hm2

• Allelic Composition: Mx1^s1/Mx1^s1
• Genetic Background: C3H

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:23752 )

• following intraperitoneal infection with Thogoto virus, 5 of 5 mice die despite treatment with an interferon inducer, poly(I)-poly(C)

Genotype
MGI:3715200

hm3

• Allelic Composition: Mx1^s1/Mx1^s1
• Genetic Background: C57BL/6

mortality/aging

increased susceptibility to Orthomyxoviridae infection induced morbidity/mortality ( J:23752 )

• following infection with Thogoto virus, 9 of 10 mice die despite treatment with an interferon inducer, poly(I)-poly(C)

• following intraperitoneal infection with Thogoto virus, 7 of 7 mice die

immune system

abnormal peritoneal macrophage morphology ( J:23752 )

• after 96 hours of Thogoto virus infection in culture, peritoneal microphages become round and detach from culture dishes

abnormal susceptibility to infection ( J:120938 )

• LD50 for hvPR8 is about 10 plaque forming units

• IFN treatment is ineffective at decreasing susceptibility to hvPR8

increased susceptibility to Orthomyxoviridae infection induced morbidity/mortality ( J:23752 )

• following infection with Thogoto virus, 9 of 10 mice die despite treatment with an interferon inducer, poly(I)-poly(C)

• following intraperitoneal infection with Thogoto virus, 7 of 7 mice die

hematopoietic system

abnormal peritoneal macrophage morphology ( J:23752 )

• after 96 hours of Thogoto virus infection in culture, peritoneal microphages become round and detach from culture dishes

Genotype
MGI:3765443

cx4

• Allelic Composition: Mx1^s1/Mx1^s1; Tg(Hmgcr-MX1)LStae/?
• Genetic Background: involves: C57BL/6 * SJL

mortality/aging

decreased susceptibility to Riboviria infection induced morbidity/mortality ( J:128067 )

• decreased lethality is observed in mice challenged with influenza A virus or VSV

• mice infected with VSV by an intracerebal route have longer mean survival times (2.7 days vs. 1.5)

decreased susceptibility to Orthomyxoviridae infection induced morbidity/mortality ( J:128067 )

• no lethality is observed in mice challenged with Thogoto virus while all the littermate controls died

• mice infected with influenza A virus by an intracerebal route have longer mean survival times (6.0 days vs. 3.9)

• mice infected with pneumotropic influenza A virus have increased rates of survival (33.3% vs 0%) for wild-type controls

immune system

decreased susceptibility to Riboviria infection ( J:128067 )

• supernatant of embryonic fibroblasts infected with VSV contains 10-40 fold less infectious particles 25 hours after infection

decreased susceptibility to Riboviria infection induced morbidity/mortality ( J:128067 )

• decreased lethality is observed in mice challenged with influenza A virus or VSV

• mice infected with VSV by an intracerebal route have longer mean survival times (2.7 days vs. 1.5)

decreased susceptibility to Orthomyxoviridae infection induced morbidity/mortality ( J:128067 )

• no lethality is observed in mice challenged with Thogoto virus while all the littermate controls died

• mice infected with influenza A virus by an intracerebal route have longer mean survival times (6.0 days vs. 3.9)

• mice infected with pneumotropic influenza A virus have increased rates of survival (33.3% vs 0%) for wild-type controls

decreased susceptibility to Orthomyxoviridae infection ( J:128067 )

• supernatant of embryonic fibroblasts infected with influenza A virus contains 10-40 fold less infectious particles 25 hours after infection

• supernatant of embryonic fibroblasts infected with Thogoto virus contains no infectious particles 3 days after infection