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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dp(16Lipi-Zbtb21)1Yey
duplication, Chr 16, Y Eugene Yu 1
MGI:3714529
Summary 13 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Dp(16Lipi-Zbtb21)1Yey/Dp(16Lipi-Zbtb21)1Yey involves: 129/Sv * 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 MGI:5690055
cx2
 		Del(16Dyrk1a-Kcnj6)14Yey/Dp(16Lipi-Zbtb21)1Yey B6.129S7-Del(16Dyrk1a-Kcnj6)14Yey/Dp(16Lipi-Zbtb21)1Yey MGI:5690044
cx3
 		Del(16Kcnj15-Mx2)13Yey/Dp(16Lipi-Zbtb21)1Yey B6.129S7-Del(16Kcnj15-Mx2)13Yey/Dp(16Lipi-Zbtb21)1Yey MGI:5690037
cx4
 		Del(16Setd4-Kcnj6)12Yey/Dp(16Lipi-Zbtb21)1Yey B6.129S7-Del(16Setd4-Kcnj6)12Yey/Dp(16Lipi-Zbtb21)1Yey MGI:5690031
cx5
 		Dp(10Prmt2-Pdxk)2Yey/0
Dp(16Lipi-Zbtb21)1Yey/0 		B6.129S7-Dp(10Prmt2-Pdxk)2Yey Dp(16Lipi-Zbtb21)1Yey MGI:4461402
cx6
 		Dp(10Prmt2-Pdxk)2Yey/0
Dp(16Lipi-Zbtb21)1Yey/0
Dp(17Abcg1-Rrp1b)3Yey/0 		B6.129S7-Dp(10Prmt2-Pdxk)2Yey Dp(16Lipi-Zbtb21)1Yey Dp(17Abcg1-Rrp1b)3Yey MGI:4461401
cx7
 		Dp(16Lipi-Zbtb21)1Yey/0
Dp(17Abcg1-Rrp1b)3Yey/0 		B6.129S7-Dp(16Lipi-Zbtb21)1Yey Dp(17Abcg1-Rrp1b)3Yey MGI:4461403
cx8
 		Del(16Cbr1-Fam3b)1Rhr/Dp(16Lipi-Zbtb21)1Yey involves: 129S6/SvEvTac * 129S7/SvEvBrd * C3H/HeJ * C3H/HeSnJ * C57BL/6 * C57BL/LiA MGI:5690021
cx9
 		Dp(16Lipi-Zbtb21)1Yey/Del(16Tiam1-Kcnj6)7Yey involves: 129S7/SvEvBrd MGI:5305774
cx10
 		Dp(16Lipi-Zbtb21)1Yey/Del(16Ifnar1-Kcnj6)11Yey involves: 129S7/SvEvBrd * C57BL/6J MGI:5562375
cx11
 		Dp(16Lipi-Zbtb21)1Yey/0
Dyrk1aGt(XQ0369)Wtsi/Dyrk1a+ 		involves: 129/Sv * 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 MGI:5690053
ot12
 		Dp(16Lipi-Zbtb21)1Yey/0 B6.129S7-Dp(16Lipi-Zbtb21)1Yey MGI:5690023
ot13
 		Dp(16Lipi-Zbtb21)1Yey/0 involves: 129S7/SvEvBrd MGI:3714532


Genotype
MGI:5690055
hm1
Allelic
Composition		 Dp(16Lipi-Zbtb21)1Yey/Dp(16Lipi-Zbtb21)1Yey
Genetic
Background		 involves: 129/Sv * 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dp(16Lipi-Zbtb21)1Yey mutation (3 available); any Dp(16Lipi-Zbtb21)1Yey mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:224899 )
• no viable pups are produced from heterozygote x heterozygote matings




Genotype
MGI:5690044
cx2
Allelic
Composition		 Del(16Dyrk1a-Kcnj6)14Yey/Dp(16Lipi-Zbtb21)1Yey
Genetic
Background		 B6.129S7-Del(16Dyrk1a-Kcnj6)14Yey/Dp(16Lipi-Zbtb21)1Yey
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(16Dyrk1a-Kcnj6)14Yey mutation (1 available); any Del(16Dyrk1a-Kcnj6)14Yey mutation (1 available)
Dp(16Lipi-Zbtb21)1Yey mutation (3 available); any Dp(16Lipi-Zbtb21)1Yey mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
impaired contextual conditioning behavior ( J:224899 )
• mice exhibit decreased freezing behavior in contextual fear-conditioning test as compared to wild type
decreased exploration in new environment ( J:224899 )
• impaired performance in T maze spontaneous alteration test as compared to wild type

nervous system
reduced long-term potentiation ( J:224899 )
• magnitude of hippocampal LTP following theta burst stimulation is lower than controls




Genotype
MGI:5690037
cx3
Allelic
Composition		 Del(16Kcnj15-Mx2)13Yey/Dp(16Lipi-Zbtb21)1Yey
Genetic
Background		 B6.129S7-Del(16Kcnj15-Mx2)13Yey/Dp(16Lipi-Zbtb21)1Yey
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(16Kcnj15-Mx2)13Yey mutation (1 available); any Del(16Kcnj15-Mx2)13Yey mutation (1 available)
Dp(16Lipi-Zbtb21)1Yey mutation (3 available); any Dp(16Lipi-Zbtb21)1Yey mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
impaired contextual conditioning behavior ( J:224899 )
• mice exhibit decreased freezing behavior in contextual fear-conditioning test as compared to wild type
decreased exploration in new environment ( J:224899 )
• impaired performance in T maze spontaneous alteration test as compared to controls

nervous system
reduced long-term potentiation ( J:224899 )
• magnitude of hippocampal LTP following theta burst stimulation is lower than controls




Genotype
MGI:5690031
cx4
Allelic
Composition		 Del(16Setd4-Kcnj6)12Yey/Dp(16Lipi-Zbtb21)1Yey
Genetic
Background		 B6.129S7-Del(16Setd4-Kcnj6)12Yey/Dp(16Lipi-Zbtb21)1Yey
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(16Setd4-Kcnj6)12Yey mutation (1 available); any Del(16Setd4-Kcnj6)12Yey mutation (1 available)
Dp(16Lipi-Zbtb21)1Yey mutation (3 available); any Dp(16Lipi-Zbtb21)1Yey mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
impaired contextual conditioning behavior ( J:224899 )
• mice exhibit decreased freezing behavior in contextual fear-conditioning test as compared to wild type
decreased exploration in new environment ( J:224899 )
• impaired performance in T maze spontaneous alteration test as compared to controls

nervous system
reduced long-term potentiation ( J:224899 )
• magnitude of hippocampal LTP following theta burst stimulation is lower than controls




Genotype
MGI:4461402
cx5
Allelic
Composition		 Dp(10Prmt2-Pdxk)2Yey/0
Dp(16Lipi-Zbtb21)1Yey/0
Genetic
Background		 B6.129S7-Dp(10Prmt2-Pdxk)2Yey Dp(16Lipi-Zbtb21)1Yey
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dp(10Prmt2-Pdxk)2Yey mutation (3 available); any Dp(10Prmt2-Pdxk)2Yey mutation (3 available)
Dp(16Lipi-Zbtb21)1Yey mutation (3 available); any Dp(16Lipi-Zbtb21)1Yey mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality ( J:161325 )
• rate of neonatal lethality is similar to mice hemizygous for Dp(16Lipi-Zfp295)1Yey alone




Genotype
MGI:4461401
cx6
Allelic
Composition		 Dp(10Prmt2-Pdxk)2Yey/0
Dp(16Lipi-Zbtb21)1Yey/0
Dp(17Abcg1-Rrp1b)3Yey/0
Genetic
Background		 B6.129S7-Dp(10Prmt2-Pdxk)2Yey Dp(16Lipi-Zbtb21)1Yey Dp(17Abcg1-Rrp1b)3Yey
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dp(10Prmt2-Pdxk)2Yey mutation (3 available); any Dp(10Prmt2-Pdxk)2Yey mutation (3 available)
Dp(16Lipi-Zbtb21)1Yey mutation (3 available); any Dp(16Lipi-Zbtb21)1Yey mutation (3 available)
Dp(17Abcg1-Rrp1b)3Yey mutation (3 available); any Dp(17Abcg1-Rrp1b)3Yey mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased survivor rate ( J:161325 )
• mice with hydrocephaly die around 6 to 8 weeks of age
premature death ( J:161325 )
• mice with hydrocephaly die around 6 to 8 weeks of age
neonatal lethality, incomplete penetrance ( J:161325 )
• about 26% die soon after birth

behavior/neurological
impaired contextual conditioning behavior ( J:161325 )
• freeze significantly less when returned to the test chamber 24 h or 72 h after initial training and foot shock
abnormal spatial learning ( J:161325 )
• display a longer latency and a longer path length to reach the hidden platform in a Morris water maze
abnormal spatial reference memory ( J:161325 )
• in a Morris water maze probe test mice spend less time in the target quadrant
impaired swimming ( J:161325 )
• decrease in swimming speed
decreased grip strength ( J:161325 )
• in all limbs

nervous system
obstructive hydrocephaly ( J:161325 )
• seen in about 6.5% of mice, associated with aqueductal stenosis
dilated lateral ventricle ( J:161325 )
• in mice with hydrocephaly
reduced long-term potentiation ( J:161325 )
• in the hippocampus

cardiovascular system
abnormal heart morphology ( J:161325 )
• display heart defects at a similar frequency to mice hemizygous for Dp(16Lipi-Zfp295)1Yey alone

reproductive system
reproductive system phenotype ( J:161325 )
N
• unlike mice carrying Ts(17<16>)65Dn , no reproductive impairment is seen in mice even when put on an inbred background

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Down syndrome DOID:14250 OMIM:190685
 J:161325




Genotype
MGI:4461403
cx7
Allelic
Composition		 Dp(16Lipi-Zbtb21)1Yey/0
Dp(17Abcg1-Rrp1b)3Yey/0
Genetic
Background		 B6.129S7-Dp(16Lipi-Zbtb21)1Yey Dp(17Abcg1-Rrp1b)3Yey
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dp(16Lipi-Zbtb21)1Yey mutation (3 available); any Dp(16Lipi-Zbtb21)1Yey mutation (3 available)
Dp(17Abcg1-Rrp1b)3Yey mutation (3 available); any Dp(17Abcg1-Rrp1b)3Yey mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality ( J:161325 )
• rate of neonatal lethality is similar to mice hemizygous for Dp(16Lipi-Zfp295)1Yey alone




Genotype
MGI:5690021
cx8
Allelic
Composition		 Del(16Cbr1-Fam3b)1Rhr/Dp(16Lipi-Zbtb21)1Yey
Genetic
Background		 involves: 129S6/SvEvTac * 129S7/SvEvBrd * C3H/HeJ * C3H/HeSnJ * C57BL/6 * C57BL/LiA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(16Cbr1-Fam3b)1Rhr mutation (1 available); any Del(16Cbr1-Fam3b)1Rhr mutation (1 available)
Dp(16Lipi-Zbtb21)1Yey mutation (3 available); any Dp(16Lipi-Zbtb21)1Yey mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
impaired contextual conditioning behavior ( J:224899 )
• mice exhibit decreased freezing behavior in contextual fear-conditioning test as compared to wild type




Genotype
MGI:5305774
cx9
Allelic
Composition		 Dp(16Lipi-Zbtb21)1Yey/Del(16Tiam1-Kcnj6)7Yey
Genetic
Background		 involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(16Tiam1-Kcnj6)7Yey mutation (1 available); any Del(16Tiam1-Kcnj6)7Yey mutation (1 available)
Dp(16Lipi-Zbtb21)1Yey mutation (3 available); any Dp(16Lipi-Zbtb21)1Yey mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:180201 )
• normal survival
• no heart defects

cardiovascular system
cardiovascular system phenotype ( J:180201 )
N
• no heart defects




Genotype
MGI:5562375
cx10
Allelic
Composition		 Dp(16Lipi-Zbtb21)1Yey/Del(16Ifnar1-Kcnj6)11Yey
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(16Ifnar1-Kcnj6)11Yey mutation (0 available); any Del(16Ifnar1-Kcnj6)11Yey mutation (0 available)
Dp(16Lipi-Zbtb21)1Yey mutation (3 available); any Dp(16Lipi-Zbtb21)1Yey mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:208104 )
N
• mice are produced unlike when Del(16Ifnar1-Kcnj6)11Yey chimeras are bred to wild-type mice




Genotype
MGI:5690053
cx11
Allelic
Composition		 Dp(16Lipi-Zbtb21)1Yey/0
Dyrk1aGt(XQ0369)Wtsi/Dyrk1a+
Genetic
Background		 involves: 129/Sv * 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dp(16Lipi-Zbtb21)1Yey mutation (3 available); any Dp(16Lipi-Zbtb21)1Yey mutation (3 available)
Dyrk1aGt(XQ0369)Wtsi mutation (1 available); any Dyrk1a mutation (112 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
impaired contextual conditioning behavior ( J:224899 )
• mice exhibit decreased freezing behavior in contextual fear-conditioning test as compared to wild type
decreased exploration in new environment ( J:224899 )
• impaired performance in T maze spontaneous alteration test as compared to controls




Genotype
MGI:5690023
ot12
Allelic
Composition		 Dp(16Lipi-Zbtb21)1Yey/0
Genetic
Background		 B6.129S7-Dp(16Lipi-Zbtb21)1Yey
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dp(16Lipi-Zbtb21)1Yey mutation (3 available); any Dp(16Lipi-Zbtb21)1Yey mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
impaired contextual conditioning behavior ( J:224899 )
• mice exhibit decreased freezing behavior in contextual fear-conditioning test as compared to wild type
decreased exploration in new environment ( J:224899 )
• impaired performance in T maze spontaneous alteration test as compared to wild type

mortality/aging
premature death ( J:241597 )
• mice that develop severe hydrocephalus die by 6 weeks of age

reproductive system
transmission ratio distortion ( J:224899 )
• duplication is transmitted at a ratio that is lower than expected

nervous system
hydrocephaly ( J:241597 )
• 35.4% of mice develop severe hydrocephalus and die by 6 weeks of age
• however, stenosis of the aqueduct of Sylvius is not seen
reduced long-term potentiation ( J:224899 )
• magnitude of hippocampal LTP following theta burst stimulation is lower than controls




Genotype
MGI:3714532
ot13
Allelic
Composition		 Dp(16Lipi-Zbtb21)1Yey/0
Genetic
Background		 involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dp(16Lipi-Zbtb21)1Yey mutation (3 available); any Dp(16Lipi-Zbtb21)1Yey mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality ( J:121790 )
• only 38% of mice are alive at weaning

cardiovascular system
aorta coarctation ( J:121790 )
• seen in 1 of 30 embryos at E18.5
abnormal heart morphology ( J:121790 )
• at E18.5, about 37% of mice have heart defects including cleft of the mitral valve, atrial septal defect, perimembranous ventricular septum defect, conal ventricular septum defect, overriding of the aorta, narrowed outflow tract of the right ventricle, tetralogy of Fallot, double outlet right ventricle and coarcation of the aorta
double outlet right ventricle ( J:121790 )
• seen in one of 30 embryos at E18.5
overriding aortic valve ( J:121790 )
• seen in 2 of 30 embryos at E18.5
abnormal mitral valve morphology ( J:121790 )
• clefting seen in 3 of 30 embryos at E18.5
atrial septal defect ( J:121790 )
• seen in 4 of 30 embryos at E18.5
perimembraneous ventricular septal defect ( J:121790 )
• seen in 5 of 30 embryos at E18.5
subarterial ventricular septal defect ( J:121790 )
• seen in 2 of 30 embryos at E18.5
heart right ventricle outflow tract stenosis ( J:121790 )
• seen in 2 of 30 embryos at E18.5

digestive/alimentary system
abnormal intestine morphology ( J:121790 )
• at E18.5, 33% of mice have malrotation of the intestine

endocrine/exocrine glands
annular pancreas ( J:121790 )
• at E18.5, in about 26% of mice

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
annular pancreas DOID:0060850 OMIM:167750
 J:121790
tetralogy of Fallot DOID:6419 OMIM:187500
 J:121790




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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory