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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Sirt1tm1.1Ygu
targeted mutation 1.1, Yansong Gu
MGI:3713747
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Sirt1tm1.1Ygu/Sirt1tm1.1Ygu involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 MGI:3713751


Genotype
MGI:3713751
hm1
Allelic
Composition
Sirt1tm1.1Ygu/Sirt1tm1.1Ygu
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sirt1tm1.1Ygu mutation (0 available); any Sirt1 mutation (78 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• two-thirds of mice die shortly after birth
• some pups generated from male Sirt1tm1.1Bpr homozygotes crossed with female Sirt1tm1.1Bpr heterozygotes die around birth

reproductive system
N
• males and females can be fertile
• even during pregnancy, ductal morphogenesis is impeded

growth/size/body

endocrine/exocrine glands
• mammary gland development following pregnancy is highly variable ranging from a lack of any ductal structure to a fully developed ductal network
• in pregnancy-induced mammary gland development, alveolar morphogenesis is inadequate
• mammary tissue exhibits increased cell proliferation and apoptosis during late pregnancy and lactation resembling mid-pregnancy levels in wild-type
• successive pregnancies do not improve mammary gland morphogenesis
• however, estrogen treatment restores mammary gland morphogenesis
• mice have impeded ductal morphogenesis
• in pregnancy-induced mammary gland development, terminal end buds are club-shaped transitional structure
• even during pregnancy, ductal morphogenesis is impeded
• severe deficit in milk production

integument
• mammary gland development following pregnancy is highly variable ranging from a lack of any ductal structure to a fully developed ductal network
• in pregnancy-induced mammary gland development, alveolar morphogenesis is inadequate
• mammary tissue exhibits increased cell proliferation and apoptosis during late pregnancy and lactation resembling mid-pregnancy levels in wild-type
• successive pregnancies do not improve mammary gland morphogenesis
• however, estrogen treatment restores mammary gland morphogenesis
• mice have impeded ductal morphogenesis
• in pregnancy-induced mammary gland development, terminal end buds are club-shaped transitional structure
• even during pregnancy, ductal morphogenesis is impeded
• severe deficit in milk production





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory