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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Engtm2.1Hma
targeted mutation 2.1, Helen M Arthur
MGI:3712802
Summary 8 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Engtm2.1Hma/Engtm2.1Hma involves: 129P2/OlaHsd * C57BL/6 MGI:3712889
ht2
Engtm1Hma/Engtm2.1Hma involves: 129P2/OlaHsd * C57BL/6 MGI:3712891
cn3
Engtm2.1Hma/Engtm2.1Hma involves: 129P2/OlaHsd MGI:5501108
cn4
Engtm2.1Hma/Engtm2.1Hma
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd MGI:5775293
cn5
Engtm2.1Hma/Engtm2.1Hma
Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ MGI:5775189
cn6
Engtm2.1Hma/Engtm2.1Hma
Tg(Tal1-cre/ERT)1Jrg/0
involves: 129P2/OlaHsd * C57BL/6 MGI:5775190
cn7
Engtm2.1Hma/Engtm2.1Hma
Tg(Tagln-cre)1Her/0
involves: 129P2/OlaHsd * C57BL/6 * SJL MGI:5775294
cn8
Engtm2.1Hma/Engtm2.1Hma
Tg(Myh11-icre/ERT2)1Soff/0
involves: 129P2/OlaHsd * FVB/N MGI:5775198


Genotype
MGI:3712889
hm1
Allelic
Composition
Engtm2.1Hma/Engtm2.1Hma
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Engtm2.1Hma mutation (2 available); any Eng mutation (39 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice are viable and fertile with no obvious phenotype




Genotype
MGI:3712891
ht2
Allelic
Composition
Engtm1Hma/Engtm2.1Hma
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Engtm1Hma mutation (1 available); any Eng mutation (39 available)
Engtm2.1Hma mutation (2 available); any Eng mutation (39 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• mice are viable




Genotype
MGI:5501108
cn3
Allelic
Composition
Engtm2.1Hma/Engtm2.1Hma
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Engtm2.1Hma mutation (2 available); any Eng mutation (39 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• mice co-injected with a Cre recombinase and a VEGF expressing adenovirus exhibit malformed vessels and increased cerebrovascular density in the brain at the injection site resembling arteriovenous malformations
• however, mutants co-injected with a Cre recombinase and a VEGF expressing adenovirus exhibit a similar degree of angiogenesis as in wild-type mice injected with the VEGF adenovirus
• co-injection of a Cre recombinase and a VEGF expressing adenovirus induces less cerebrovascular dysplasia in mutants than in similarly injected Acvrl1tm2.1Spo homozygotes, however gene deletion efficiency is lower in this mutant and when gene deletion efficiency is the same, then these mutants show more dysplastic vessels per gene copy than the Acvrl1 mutant

nervous system
• mice co-injected with a Cre recombinase and a VEGF expressing adenovirus exhibit malformed vessels and increased cerebrovascular density in the brain at the injection site resembling arteriovenous malformations
• however, mutants co-injected with a Cre recombinase and a VEGF expressing adenovirus exhibit a similar degree of angiogenesis as in wild-type mice injected with the VEGF adenovirus
• co-injection of a Cre recombinase and a VEGF expressing adenovirus induces less cerebrovascular dysplasia in mutants than in similarly injected Acvrl1tm2.1Spo homozygotes, however gene deletion efficiency is lower in this mutant and when gene deletion efficiency is the same, then these mutants show more dysplastic vessels per gene copy than the Acvrl1 mutant

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
arteriovenous malformations of the brain DOID:0060688 OMIM:108010
J:196810




Genotype
MGI:5775293
cn4
Allelic
Composition
Engtm2.1Hma/Engtm2.1Hma
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Engtm2.1Hma mutation (2 available); any Eng mutation (39 available)
Lyz2tm1(cre)Ifo mutation (13 available); any Lyz2 mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
N
• tamoxifen treated mice do not develop arteriovenous malformations in response to AAV-VEGF injection into the basal ganglia at 8-10 weeks of age or around the ear tag wound




Genotype
MGI:5775189
cn5
Allelic
Composition
Engtm2.1Hma/Engtm2.1Hma
Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Engtm2.1Hma mutation (2 available); any Eng mutation (39 available)
Gt(ROSA)26Sortm1(cre/ERT)Nat mutation (3 available); any Gt(ROSA)26Sor mutation (781 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice display signs of illness in 3-4 days after the first tamoxifen injection which includes slow movement

cardiovascular system
• adults injected with tamoxifen for 3 days develop arteriovenous malformations in AAV-VEGF-induced brain angiogenic foci 8 weeks after induction, with lesions consisting of enlarged vessels (J:212952)
• tamoxifen treated adults develop arteriovenous malformations around the ear-tag wound (J:212952)
• areas of wounds in mid-dorsum and ear of tamoxifen-injected mice show the presence of arteriovenous (AV) shunts (J:227170)
• macrophages and microhemorrhage are seen around dysplastic vessels of AAV-VEGF injected, tamoxifen treated mice in the brain
• tamoxifen treated adults develop arteriovenous malformations around the ear-tag wound (J:212952)
• areas of wounds in mid-dorsum and ear of tamoxifen-injected mice show dilated and torturous vessels and the presence of arteriovenous (AV) shunts (J:227170)
• however, blood vessels away from the wound have normal morphology (J:227170)

digestive/alimentary system
• mice display signs of illness in 3-4 days after the first tamoxifen injection which includes diarrhea

homeostasis/metabolism
• tamoxifen treated adults develop arteriovenous malformations around the ear-tag wound (J:212952)
• areas of wounds in mid-dorsum and ear of tamoxifen-injected mice show dilated and torturous vessels and the presence of arteriovenous (AV) shunts (J:227170)
• however, blood vessels away from the wound have normal morphology (J:227170)
• mice display signs of illness in 3-4 days after the first tamoxifen injection which includes dehydration

mortality/aging
• mice die around day 4-10 after the first tamoxifen treatment




Genotype
MGI:5775190
cn6
Allelic
Composition
Engtm2.1Hma/Engtm2.1Hma
Tg(Tal1-cre/ERT)1Jrg/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Engtm2.1Hma mutation (2 available); any Eng mutation (39 available)
Tg(Tal1-cre/ERT)1Jrg mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• tamoxifen-injected adults subjected to wounding exhibit multiple arteriovenous (AV) shunts in the punched area of both the ear and the back skin
• tamoxifen-injected adults subjected to wounding exhibit tortuous and enlarged blood vessels and present multiple arteriovenous (AV) shunts in the punched area of both the ear and the back skin
• however, tamoxifen-treated mice do not exhibit signs of hemorrhages or arteriovenous malformations in internal organs and survive longer than a month

homeostasis/metabolism
• tamoxifen-injected adults subjected to wounding exhibit tortuous and enlarged blood vessels and present multiple arteriovenous (AV) shunts in the punched area of both the ear and the back skin
• however, tamoxifen-treated mice do not exhibit signs of hemorrhages or arteriovenous malformations in internal organs and survive longer than a month




Genotype
MGI:5775294
cn7
Allelic
Composition
Engtm2.1Hma/Engtm2.1Hma
Tg(Tagln-cre)1Her/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Engtm2.1Hma mutation (2 available); any Eng mutation (39 available)
Tg(Tagln-cre)1Her mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• dilated and dysmorphic vessels in brains of 5 week old mice
• 90% of 5 week old mice exhibit arteriovenous malformations with greatly enlarged and tortuous vessels in the brain
• more than 80% of mice have one arteriovenous malformation lesion, while the remaining 20% have 2-3 lesions
• arteriovenous (A-V) shunting and hemorrhage are seen in some brain and spinal cord lesions
• arteriovenous malformations are also seen in the spinal cord and intestine
• hemorrhage is seen in some brain and spinal cord lesions
• macrophages and microhemorrhage are seen around dysplastic vessels in the brain

digestive/alimentary system
• arteriovenous malformations are also seen in the spinal cord and intestine

mortality/aging
• more than 50% of mice before 6 weeks of age




Genotype
MGI:5775198
cn8
Allelic
Composition
Engtm2.1Hma/Engtm2.1Hma
Tg(Myh11-icre/ERT2)1Soff/0
Genetic
Background
involves: 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Engtm2.1Hma mutation (2 available); any Eng mutation (39 available)
Tg(Myh11-icre/ERT2)1Soff mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
N
• tamoxifen treated adults do not exhibit arteriovenous (AV) shunts in any areas of the skin including the wound areas





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last database update
09/22/2022
MGI 6.21
The Jackson Laboratory