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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ightm2Mnz
targeted mutation 2, Michel C Nussenzweig
MGI:3712225
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ightm2Mnz/Ightm2Mnz B6.129P2-Ightm2Mnz MGI:3712643
cx2
 		H2axtm1Nus/H2axtm1Nus
Ightm2Mnz/Ightm2Mnz 		involves: 129P2/OlaHsd MGI:3712650
cx3
 		Ightm2Mnz/Ightm2Mnz
Lyntm1Sor/Lyntm1Sor 		involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 MGI:3712646
cx4
 		Cd19tm1(cre)Cgn/Cd19tm1(cre)Cgn
Ightm2Mnz/Ightm2Mnz 		involves: 129P2/OlaHsd * C57BL/6 MGI:3712644


Genotype
MGI:3712643
hm1
Allelic
Composition		 Ightm2Mnz/Ightm2Mnz
Genetic
Background		 B6.129P2-Ightm2Mnz
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ightm2Mnz mutation (1 available); any Igh mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
cellular phenotype ( J:75653 )
N
• 3 and 5 days after immunization, there is no evidence of increased B cell apoptosis relative to wild-type
increased B cell proliferation ( J:75653 )
• mutant B cells in mice challenged with a T1-2 antigen (NP-Ficoll) undergo rapid proliferative expansion (from 3 to 14% of lymphocytes by 5 days after immunization
• in immunized mice, on day 2 there is a higher percentage of low-affinity B cells (20%) compared to wild-type cells (~3%)

immune system
increased B cell proliferation ( J:75653 )
• mutant B cells in mice challenged with a T1-2 antigen (NP-Ficoll) undergo rapid proliferative expansion (from 3 to 14% of lymphocytes by 5 days after immunization
• in immunized mice, on day 2 there is a higher percentage of low-affinity B cells (20%) compared to wild-type cells (~3%)
increased IgG level ( J:75653 )
• 4-hydroxy-3-nitrophenyl)acetyl-specific (NP) IgM antibody production is greater than in wild-type
increased IgM level ( J:75653 )
• NP-specific IgM antibody production is greater than in wild-type

hematopoietic system
increased B cell proliferation ( J:75653 )
• mutant B cells in mice challenged with a T1-2 antigen (NP-Ficoll) undergo rapid proliferative expansion (from 3 to 14% of lymphocytes by 5 days after immunization
• in immunized mice, on day 2 there is a higher percentage of low-affinity B cells (20%) compared to wild-type cells (~3%)
increased IgG level ( J:75653 )
• 4-hydroxy-3-nitrophenyl)acetyl-specific (NP) IgM antibody production is greater than in wild-type
increased IgM level ( J:75653 )
• NP-specific IgM antibody production is greater than in wild-type




Genotype
MGI:3712650
cx2
Allelic
Composition		 H2axtm1Nus/H2axtm1Nus
Ightm2Mnz/Ightm2Mnz
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2axtm1Nus mutation (1 available); any H2ax mutation (7 available)
Ightm2Mnz mutation (1 available); any Igh mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:120658 )
N
• the rate of somatic hypermutation is normal




Genotype
MGI:3712646
cx3
Allelic
Composition		 Ightm2Mnz/Ightm2Mnz
Lyntm1Sor/Lyntm1Sor
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ightm2Mnz mutation (1 available); any Igh mutation (43 available)
Lyntm1Sor mutation (2 available); any Lyn mutation (64 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell physiology ( J:75653 )
• number of B cells differentiating into germinal center B cells and plasmacytes is diminished compared to Ightm2Mnz mice
increased B cell proliferation ( J:75653 )
• antigen specific B cell proliferation is similar to wild-type CD19 Ightm2Mnz mice
• expansion is prolonged with increased levels of Ig lambda+ cells remaining 12 days after immunization

hematopoietic system
abnormal B cell physiology ( J:75653 )
• number of B cells differentiating into germinal center B cells and plasmacytes is diminished compared to Ightm2Mnz mice
increased B cell proliferation ( J:75653 )
• antigen specific B cell proliferation is similar to wild-type CD19 Ightm2Mnz mice
• expansion is prolonged with increased levels of Ig lambda+ cells remaining 12 days after immunization

cellular
increased B cell proliferation ( J:75653 )
• antigen specific B cell proliferation is similar to wild-type CD19 Ightm2Mnz mice
• expansion is prolonged with increased levels of Ig lambda+ cells remaining 12 days after immunization




Genotype
MGI:3712644
cx4
Allelic
Composition		 Cd19tm1(cre)Cgn/Cd19tm1(cre)Cgn
Ightm2Mnz/Ightm2Mnz
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (56 available)
Ightm2Mnz mutation (1 available); any Igh mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell physiology ( J:75653 )
• B cells show no response to NP-Ficoll immunization compared to wild-type CD19 Ightm2Mnz mice or CD19-null Ightm1Mnz mice

hematopoietic system
abnormal B cell physiology ( J:75653 )
• B cells show no response to NP-Ficoll immunization compared to wild-type CD19 Ightm2Mnz mice or CD19-null Ightm1Mnz mice




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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory