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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ets1tm1.1Dds
targeted mutation 1.1, Demetri D Spyropoulos
MGI:3711457
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ets1tm1.1Dds/Ets1tm1.1Dds 129S6/SvEvTac-Ets1tm1.1Dds MGI:3712142
ht2
Ets1tm1.1Dds/Ets1+ 129S6/SvEvTac-Ets1tm1.1Dds MGI:3712143


Genotype
MGI:3712142
hm1
Allelic
Composition
Ets1tm1.1Dds/Ets1tm1.1Dds
Genetic
Background
129S6/SvEvTac-Ets1tm1.1Dds
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ets1tm1.1Dds mutation (0 available); any Ets1 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• homozygous mice are born at less than the expected Mendelian ratio from heterozygous intercrosses
• homozygous mice are born at less than the expected Mendelian ratio from heterozygous intercrosses

immune system
• thymocytes show a 50% reduction in frequency of apoptosis compared to wild-type littermates
• 2-fold increase in frequency of apoptosis in spleen is detected
• a trend toward an increased relative proportion of double-negative thymocytes is seen relative to wild-type
• thymocytes show a 50% reduction in frequency of apoptosis compared to wild-type littermates
• zone of proliferating cells in subcapsular region in mutants is less organized and less distinct than in wild-type mice
• in mutant thymus, majority of proliferating cells are cortical thymocytes in contrast to the wild-type thymus where most proliferating cells are in the subcapsular region
• mice have pronounced thymic enlargement
• thymic weight is increased by 60% compared to wild-type littermates; thymus:body mass ratio is 69% higher than in wild-type mice
• based on normalized cell numbers, B and T cell populations are significantly reduced in 8-16 week old mice
• increase of 45% in CD4+CD8+ cells is seen
• mice show peripheral blood lymphopenia with incomplete penetrance (3/7 mice)
• affected mice have 50% reduction in leukocyte number per volume of blood and a 2-fold increase in relative percentage of myeloid cells
• B cell numbers in peripheral lymphoid compartment are reduced by 34% in 8-16 week old mice
• CD4+ T cells are reduced 29% relative to wild-type in 8-16 week old mice
• 40% reduction in frequency of CD44-expressing cells is observed, suggesting a deficit in memory T cell development
• increased relative frequency of CD4-CD8+ cells (25%) is observed
• when normalized to total cell numbers, increase in CD4-CD8+ cell number is 86%
• increase in normalized CD4-CD8+ cell number is not accompanied by increase in CD4+CD8- cell number
• in peripheral lymphoid compartment, CD8+ T cells are reduced by 38% in 8-16 week old mice
• 42% decrease in nonmyeloid cells based on normalized cell numbers; there is a trend to increased proportion of myeloid cells
• 2-fold increase in frequency of apoptosis in spleen is detected
• homozygotes show a marked increase in proliferation of splenocytes in the red pulp
• mice show microsplenia
• 34% decrease in spleen weight relative to wild-type is found; spleen:body mass is reduced 31.5% compared to controls

hematopoietic system
• thymocytes show a 50% reduction in frequency of apoptosis compared to wild-type littermates
• 2-fold increase in frequency of apoptosis in spleen is detected
• a trend toward an increased relative proportion of double-negative thymocytes is seen relative to wild-type
• thymocytes show a 50% reduction in frequency of apoptosis compared to wild-type littermates
• zone of proliferating cells in subcapsular region in mutants is less organized and less distinct than in wild-type mice
• in mutant thymus, majority of proliferating cells are cortical thymocytes in contrast to the wild-type thymus where most proliferating cells are in the subcapsular region
• mice have pronounced thymic enlargement
• thymic weight is increased by 60% compared to wild-type littermates; thymus:body mass ratio is 69% higher than in wild-type mice
• based on normalized cell numbers, B and T cell populations are significantly reduced in 8-16 week old mice
• increase of 45% in CD4+CD8+ cells is seen
• mice show peripheral blood lymphopenia with incomplete penetrance (3/7 mice)
• affected mice have 50% reduction in leukocyte number per volume of blood and a 2-fold increase in relative percentage of myeloid cells
• B cell numbers in peripheral lymphoid compartment are reduced by 34% in 8-16 week old mice
• CD4+ T cells are reduced 29% relative to wild-type in 8-16 week old mice
• 40% reduction in frequency of CD44-expressing cells is observed, suggesting a deficit in memory T cell development
• increased relative frequency of CD4-CD8+ cells (25%) is observed
• when normalized to total cell numbers, increase in CD4-CD8+ cell number is 86%
• increase in normalized CD4-CD8+ cell number is not accompanied by increase in CD4+CD8- cell number
• in peripheral lymphoid compartment, CD8+ T cells are reduced by 38% in 8-16 week old mice
• 42% decrease in nonmyeloid cells based on normalized cell numbers; there is a trend to increased proportion of myeloid cells
• 2-fold increase in frequency of apoptosis in spleen is detected
• homozygotes show a marked increase in proliferation of splenocytes in the red pulp
• mice show microsplenia
• 34% decrease in spleen weight relative to wild-type is found; spleen:body mass is reduced 31.5% compared to controls

cellular
• thymocytes show a 50% reduction in frequency of apoptosis compared to wild-type littermates
• 2-fold increase in frequency of apoptosis in spleen is detected
• a marked increase in proliferating cells in spleen and thymus relative to wild-type controls is observed

endocrine/exocrine glands
• thymocytes show a 50% reduction in frequency of apoptosis compared to wild-type littermates
• a trend toward an increased relative proportion of double-negative thymocytes is seen relative to wild-type
• thymocytes show a 50% reduction in frequency of apoptosis compared to wild-type littermates
• zone of proliferating cells in subcapsular region in mutants is less organized and less distinct than in wild-type mice
• in mutant thymus, majority of proliferating cells are cortical thymocytes in contrast to the wild-type thymus where most proliferating cells are in the subcapsular region
• mice have pronounced thymic enlargement
• thymic weight is increased by 60% compared to wild-type littermates; thymus:body mass ratio is 69% higher than in wild-type mice




Genotype
MGI:3712143
ht2
Allelic
Composition
Ets1tm1.1Dds/Ets1+
Genetic
Background
129S6/SvEvTac-Ets1tm1.1Dds
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ets1tm1.1Dds mutation (0 available); any Ets1 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• thymocytes show a 50% reduction in frequency of apoptosis compared to wild-type littermates
• 2-fold increase in frequency of apoptosis in spleen is detected
• enlargement is more moderate compared to homozygotes
• thymic weight is increased by 30% compared to wild-type littermates
• slight reduction in frequency of CD44-expressing cells is observed, suggesting a deficit in memory T cell development
• a 50% reduction in cells memory cells (showing high CD44 expression) is observed in spleen, compared to controls

immune system
• thymocytes show a 50% reduction in frequency of apoptosis compared to wild-type littermates
• 2-fold increase in frequency of apoptosis in spleen is detected
• enlargement is more moderate compared to homozygotes
• thymic weight is increased by 30% compared to wild-type littermates
• slight reduction in frequency of CD44-expressing cells is observed, suggesting a deficit in memory T cell development
• a 50% reduction in cells memory cells (showing high CD44 expression) is observed in spleen, compared to controls

cellular
• thymocytes show a 50% reduction in frequency of apoptosis compared to wild-type littermates
• 2-fold increase in frequency of apoptosis in spleen is detected

endocrine/exocrine glands
• thymocytes show a 50% reduction in frequency of apoptosis compared to wild-type littermates
• enlargement is more moderate compared to homozygotes
• thymic weight is increased by 30% compared to wild-type littermates





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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory