Analysis Tools
mortality/aging
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• homozygous mice are born at less than the expected Mendelian ratio from heterozygous intercrosses
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• homozygous mice are born at less than the expected Mendelian ratio from heterozygous intercrosses
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immune system
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• thymocytes show a 50% reduction in frequency of apoptosis compared to wild-type littermates
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• 2-fold increase in frequency of apoptosis in spleen is detected
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• a trend toward an increased relative proportion of double-negative thymocytes is seen relative to wild-type
• thymocytes show a 50% reduction in frequency of apoptosis compared to wild-type littermates
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• zone of proliferating cells in subcapsular region in mutants is less organized and less distinct than in wild-type mice
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• in mutant thymus, majority of proliferating cells are cortical thymocytes in contrast to the wild-type thymus where most proliferating cells are in the subcapsular region
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• mice have pronounced thymic enlargement
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• thymic weight is increased by 60% compared to wild-type littermates; thymus:body mass ratio is 69% higher than in wild-type mice
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• based on normalized cell numbers, B and T cell populations are significantly reduced in 8-16 week old mice
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• increase of 45% in CD4+CD8+ cells is seen
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• mice show peripheral blood lymphopenia with incomplete penetrance (3/7 mice)
• affected mice have 50% reduction in leukocyte number per volume of blood and a 2-fold increase in relative percentage of myeloid cells
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• B cell numbers in peripheral lymphoid compartment are reduced by 34% in 8-16 week old mice
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• CD4+ T cells are reduced 29% relative to wild-type in 8-16 week old mice
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• 40% reduction in frequency of CD44-expressing cells is observed, suggesting a deficit in memory T cell development
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• increased relative frequency of CD4-CD8+ cells (25%) is observed
• when normalized to total cell numbers, increase in CD4-CD8+ cell number is 86%
• increase in normalized CD4-CD8+ cell number is not accompanied by increase in CD4+CD8- cell number
• in peripheral lymphoid compartment, CD8+ T cells are reduced by 38% in 8-16 week old mice
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• 42% decrease in nonmyeloid cells based on normalized cell numbers; there is a trend to increased proportion of myeloid cells
• 2-fold increase in frequency of apoptosis in spleen is detected
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• homozygotes show a marked increase in proliferation of splenocytes in the red pulp
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small spleen
(
J:121460
)
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• mice show microsplenia
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• 34% decrease in spleen weight relative to wild-type is found; spleen:body mass is reduced 31.5% compared to controls
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hematopoietic system
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• thymocytes show a 50% reduction in frequency of apoptosis compared to wild-type littermates
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• 2-fold increase in frequency of apoptosis in spleen is detected
|
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• a trend toward an increased relative proportion of double-negative thymocytes is seen relative to wild-type
• thymocytes show a 50% reduction in frequency of apoptosis compared to wild-type littermates
|
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• zone of proliferating cells in subcapsular region in mutants is less organized and less distinct than in wild-type mice
|
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• in mutant thymus, majority of proliferating cells are cortical thymocytes in contrast to the wild-type thymus where most proliferating cells are in the subcapsular region
|
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• mice have pronounced thymic enlargement
|
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• thymic weight is increased by 60% compared to wild-type littermates; thymus:body mass ratio is 69% higher than in wild-type mice
|
|
• based on normalized cell numbers, B and T cell populations are significantly reduced in 8-16 week old mice
|
|
• increase of 45% in CD4+CD8+ cells is seen
|
|
• mice show peripheral blood lymphopenia with incomplete penetrance (3/7 mice)
• affected mice have 50% reduction in leukocyte number per volume of blood and a 2-fold increase in relative percentage of myeloid cells
|
|
• B cell numbers in peripheral lymphoid compartment are reduced by 34% in 8-16 week old mice
|
|
• CD4+ T cells are reduced 29% relative to wild-type in 8-16 week old mice
|
|
• 40% reduction in frequency of CD44-expressing cells is observed, suggesting a deficit in memory T cell development
|
|
• increased relative frequency of CD4-CD8+ cells (25%) is observed
• when normalized to total cell numbers, increase in CD4-CD8+ cell number is 86%
• increase in normalized CD4-CD8+ cell number is not accompanied by increase in CD4+CD8- cell number
• in peripheral lymphoid compartment, CD8+ T cells are reduced by 38% in 8-16 week old mice
|
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• 42% decrease in nonmyeloid cells based on normalized cell numbers; there is a trend to increased proportion of myeloid cells
• 2-fold increase in frequency of apoptosis in spleen is detected
|
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• homozygotes show a marked increase in proliferation of splenocytes in the red pulp
|
small spleen
(
J:121460
)
|
• mice show microsplenia
|
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• 34% decrease in spleen weight relative to wild-type is found; spleen:body mass is reduced 31.5% compared to controls
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cellular
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• thymocytes show a 50% reduction in frequency of apoptosis compared to wild-type littermates
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• 2-fold increase in frequency of apoptosis in spleen is detected
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• a marked increase in proliferating cells in spleen and thymus relative to wild-type controls is observed
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endocrine/exocrine glands
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• thymocytes show a 50% reduction in frequency of apoptosis compared to wild-type littermates
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• a trend toward an increased relative proportion of double-negative thymocytes is seen relative to wild-type
• thymocytes show a 50% reduction in frequency of apoptosis compared to wild-type littermates
|
|
• zone of proliferating cells in subcapsular region in mutants is less organized and less distinct than in wild-type mice
|
|
• in mutant thymus, majority of proliferating cells are cortical thymocytes in contrast to the wild-type thymus where most proliferating cells are in the subcapsular region
|
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• mice have pronounced thymic enlargement
|
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• thymic weight is increased by 60% compared to wild-type littermates; thymus:body mass ratio is 69% higher than in wild-type mice
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