Mouse Genome Informatics
cn1
    Cxadrtm1Mds/Cxadrtm1.1Mds
Tg(Tnnt2-cre)5Blh/0

involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• no live conditional null mice are found at 4 weeks after birth; embryos at E10.5; mice display identical phenotype to Cxadrtm1.1Mds homozygotes

cardiovascular system
• at E10.5, engorgement of the cardinal veins is apparent
• hyperplasia of proximal heart tube is seen at E10.5
• sinuatrial valves located at junction between sinus venosus and atrium in wild-type embryos, are absent


Mouse Genome Informatics
cn2
    Cxadrtm1Mds/Cxadrtm1Mds
Tg(Tnnt2-cre)5Blh/0

involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• no live conditional null mice are found at 4 weeks after birth; embryos at E10.5; mice display identical phenotype to Cxadrtm1.1Mds homozygotes

cardiovascular system
• at E10.5, engorgement of the cardinal veins is apparent
• hyperplasia of proximal heart tube is seen at E10.5
• sinuatrial valves located at junction between sinus venosus and atrium in wild-type embryos, are absent


Mouse Genome Informatics
cn3
    Cxadrtm1Mds/Cxadrtm1Mds
Tg(Myh6-cre)2182Mds/0

involves: 129S1/Sv * 129X1/SvJ * FVB/N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
N
• many conditional null mice are born alive and survive to adulthood (20/102) (J:121400)

cardiovascular system
• sinuatrial valves show mild abnormalities in embryos, with only 1 embryo showing absence or attenuation comparable to constitutive null mice
• embryos show only mild or no abnormal ventricular thickening with little or no increase in proliferating cells


Mouse Genome Informatics
cn4
    Cxadrtm1Mds/Cxadrtm1.1Mds
Tg(Myh6-cre)2182Mds/0

involves: 129S1/Sv * 129X1/SvJ * FVB/N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
N
• many conditional null mice are born alive and survive to adulthood (20/102) (J:121400)

cardiovascular system
• sinuatrial valves show mild abnormalities in embryos, with only 1 embryo showing absence or attenuation comparable to constitutive null mice
• embryos show only mild or no abnormal ventricular thickening with little or no increase in proliferating cells