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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Prnp-ITM2B/APP695*40)1Emcg
transgene insertion 1, Eileen McGowan
MGI:3710691
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
 		Tg(Prnp-ITM2B/APP695*40)1Emcg/0 involves: C3H * C57BL/6 MGI:3710761


Genotype
MGI:3710761
tg1
Allelic
Composition		 Tg(Prnp-ITM2B/APP695*40)1Emcg/0
Genetic
Background		 involves: C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Prnp-ITM2B/APP695*40)1Emcg mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:101023 )
N
• mice do not show Abeta deposits or amyloid plaque formation

homeostasis/metabolism
amyloidosis ( J:101023 )
• Abeta1-40 peptide levels in 3 month old transgenic brains are ~2- to 3-fold higher than levels in Tg(APPSWE)2576Kahs controls (80-120 pm/g vs ~40 pm/g)

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Alzheimer's disease DOID:10652 J:101023




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory