Analysis Tools
mortality/aging
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• second distinct increase in mortality during weaning
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• 1/3 of mice die during the first week of life with continuous decline afterwards
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immune system
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• binding to E- and P-selection is decreased compared to in control mice
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• marked decrease in leukocyte rolling flux fraction compared with control mice and is completely dependent on alpha4-integrin
• rolling velocity is reduced to 32.2+/-1.2um/s compared to 28.3+/-1.1um/s in controls and is not affected by E- or P-selectin antibodies
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• 2.6-fold increase compared to wild-type
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• 3-fold increase compared to wild-type
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• 5-fold increase compared to wild-type
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• 2.2-fold increase compared to wild-type
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• 3.3-fold increase compared to wild-type
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• rudimentary or even absent
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• peripheral lymph nodes are hypocellular
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respiratory system
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• alveolar walls are thin
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• dilated alveoles
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reproductive system
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• 50% of females are fertile
• reduced fertility reflects aborted pregnancies, very small litters and failure to nurture pups
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• females have reduced litter size
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• 50% are fertile
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behavior/neurological
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• bent
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• females fail to nurture pups
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growth/size/body
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• postnatal retardation in weight gain
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homeostasis/metabolism
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• vesicles from liver homogenates are unable to import fucose and mice are subsequently deficient in fucosylation
• however, supplementing mice or MEF cells with high levels of fucose restores fucose levels within the cells
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hematopoietic system
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• binding to E- and P-selection is decreased compared to in control mice
|
|
• marked decrease in leukocyte rolling flux fraction compared with control mice and is completely dependent on alpha4-integrin
• rolling velocity is reduced to 32.2+/-1.2um/s compared to 28.3+/-1.1um/s in controls and is not affected by E- or P-selectin antibodies
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• 2.6-fold increase compared to wild-type
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• 3-fold increase compared to wild-type
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• 5-fold increase compared to wild-type
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• 2.2-fold increase compared to wild-type
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• 3.3-fold increase compared to wild-type
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integument
ruffled hair
(
J:121151
)
cellular
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• binding to E- and P-selection is decreased compared to in control mice
|
|
• marked decrease in leukocyte rolling flux fraction compared with control mice and is completely dependent on alpha4-integrin
• rolling velocity is reduced to 32.2+/-1.2um/s compared to 28.3+/-1.1um/s in controls and is not affected by E- or P-selectin antibodies
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| congenital disorder of glycosylation type IIc | DOID:0070255 |
OMIM:266265 |
J:121151 | |
