Mouse Genome Informatics
cx1
    Blnktm1Pjln/Blnktm1Pjln
Btktm1Gsv/Y
Tg(CD19-BTK*K430R)XK24Rwhe/?

involves: 129P2/OlaHsd * BALB/c * C57BL/6 * FVB
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• B cell development is partially restored, by about 4-7 fold (J:94768)
• some differentiation into mature B cells occurs (J:94768)
• recirculationg B cell population in the bone marrow is improved (J:94768)
• IgG3 levels remain severely reduced (J:94768)
• improved or restored (J:94768)

tumorigenesis
N
• tumor suppressor function is restored (J:94768)

hematopoietic system
• B cell development is partially restored, by about 4-7 fold (J:94768)
• some differentiation into mature B cells occurs (J:94768)
• recirculationg B cell population in the bone marrow is improved (J:94768)
• IgG3 levels remain severely reduced (J:94768)
• improved or restored (J:94768)


Mouse Genome Informatics
cx2
    Btktm1Gsv/Y
Tg(CD19-BTK*K430R)XK24Rwhe/?

involves: 129P2/OlaHsd * C57BL/6 * FVB
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
N
• calcium signaling of splenic B cells is restored (J:94768)
• B cell apoptosis is reduced compared to similar mice lacking the transgene (J:120989)
• restored B220+ cell numbers peripherally (J:120989)
• deficiency of CD5+ B cells in the peritoneum remains (J:120989)
• differentiation is partially restored (J:120989)
• decreased lambda light chain usage (J:120989)

hematopoietic system
• B cell apoptosis is reduced compared to similar mice lacking the transgene (J:120989)
• restored B220+ cell numbers peripherally (J:120989)
• deficiency of CD5+ B cells in the peritoneum remains (J:120989)
• differentiation is partially restored (J:120989)
• decreased lambda light chain usage (J:120989)

cellular
• B cell apoptosis is reduced compared to similar mice lacking the transgene (J:120989)