Mouse Genome Informatics
cx1
     Blnktm1Pjln/Blnktm1Pjln
Btktm1Gsv/Y
Tg(CD19-BTK*K430R)XK24Rwhe/?
involves: 129P2/OlaHsd * BALB/c * C57BL/6 * FVB
Key:
♀ phenotype observed in females WTSI Wellcome Trust Sanger Institute
♂ phenotype observed in males Euro Europhenome
N normal phenotype
immune system
abnormal B cell differentiation ( J:94768 )
• B cell development is partially restored, by about 4-7 fold (J:94768)
• some differentiation into mature B cells occurs (J:94768)
• recirculationg B cell population in the bone marrow is improved (J:94768)
decreased IgG3 level ( J:94768 )
• IgG3 levels remain severely reduced (J:94768)
decreased IgM level ( J:94768 )
• improved or restored (J:94768)

tumorigenesis
tumorigenesis ( J:94768 )
N
• tumor suppressor function is restored (J:94768)

hematopoietic system
abnormal B cell differentiation ( J:94768 )
• B cell development is partially restored, by about 4-7 fold (J:94768)
• some differentiation into mature B cells occurs (J:94768)
• recirculationg B cell population in the bone marrow is improved (J:94768)

cellular
abnormal B cell differentiation ( J:94768 )
• B cell development is partially restored, by about 4-7 fold (J:94768)
• some differentiation into mature B cells occurs (J:94768)
• recirculationg B cell population in the bone marrow is improved (J:94768)


Mouse Genome Informatics
cx2
     Btktm1Gsv/Y
Tg(CD19-BTK*K430R)XK24Rwhe/?
involves: 129P2/OlaHsd * C57BL/6 * FVB
Key:
♀ phenotype observed in females WTSI Wellcome Trust Sanger Institute
♂ phenotype observed in males Euro Europhenome
N normal phenotype
immune system
immune system phenotype ( J:94768 )
N
• calcium signaling of splenic B cells is restored (J:94768)
decreased B cell apoptosis ( J:120989 )
• B cell apoptosis is reduced compared to similar mice lacking the transgene (J:120989)
abnormal pre-B cell morphology ( J:120989 )
• differentiation is partially restored (J:120989)
decreased B cell number ( J:120989 )
• restored B220+ cell numbers peripherally (J:120989)
absent B-1a cells ( J:120989 )
• deficiency of CD5+ B cells in the peritoneum remains (J:120989)
decreased immunoglobulin level ( J:120989 )
• decreased lambda light chain usage (J:120989)

hematopoietic system
abnormal pre-B cell morphology ( J:120989 )
• differentiation is partially restored (J:120989)
decreased B cell number ( J:120989 )
• restored B220+ cell numbers peripherally (J:120989)
absent B-1a cells ( J:120989 )
• deficiency of CD5+ B cells in the peritoneum remains (J:120989)

cellular
decreased B cell apoptosis ( J:120989 )
• B cell apoptosis is reduced compared to similar mice lacking the transgene (J:120989)
abnormal pre-B cell morphology ( J:120989 )
• differentiation is partially restored (J:120989)