Mouse Genome Informatics
cx1
    Blnktm1Pjln/Blnktm1Pjln
Btktm1Gsv/Y
Tg(CD19-BTK*K430R)XK24Rwhe/?

involves: 129P2/OlaHsd * BALB/c * C57BL/6 * FVB
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• B cell development is partially restored, by about 4-7 fold
• some differentiation into mature B cells occurs
• recirculationg B cell population in the bone marrow is improved
• IgG3 levels remain severely reduced
• improved or restored

tumorigenesis
N
• tumor suppressor function is restored

hematopoietic system
• B cell development is partially restored, by about 4-7 fold
• some differentiation into mature B cells occurs
• recirculationg B cell population in the bone marrow is improved
• IgG3 levels remain severely reduced
• improved or restored


Mouse Genome Informatics
cx2
    Btktm1Gsv/Y
Tg(CD19-BTK*K430R)XK24Rwhe/?

involves: 129P2/OlaHsd * C57BL/6 * FVB
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• calcium signaling of splenic B cells is restored
• B cell apoptosis is reduced compared to similar mice lacking the transgene
• restored B220+ cell numbers peripherally
• deficiency of CD5+ B cells in the peritoneum remains
• differentiation is partially restored
• decreased lambda light chain usage

hematopoietic system
• B cell apoptosis is reduced compared to similar mice lacking the transgene
• restored B220+ cell numbers peripherally
• deficiency of CD5+ B cells in the peritoneum remains
• differentiation is partially restored
• decreased lambda light chain usage

cellular
• B cell apoptosis is reduced compared to similar mice lacking the transgene