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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(CD19-BTK*K430R)XK24Rwhe
transgene insertion XK24, Rudolf Hendriks
MGI:3709262
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Blnktm1Pjln/Blnktm1Pjln
Btktm1Gsv/Y
Tg(CD19-BTK*K430R)XK24Rwhe/?
involves: 129P2/OlaHsd * BALB/c * C57BL/6 * FVB MGI:3709379
cx2
Btktm1Gsv/Y
Tg(CD19-BTK*K430R)XK24Rwhe/?
involves: 129P2/OlaHsd * C57BL/6 * FVB MGI:3709381


Genotype
MGI:3709379
cx1
Allelic
Composition
Blnktm1Pjln/Blnktm1Pjln
Btktm1Gsv/Y
Tg(CD19-BTK*K430R)XK24Rwhe/?
Genetic
Background
involves: 129P2/OlaHsd * BALB/c * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Blnktm1Pjln mutation (0 available); any Blnk mutation (58 available)
Btktm1Gsv mutation (0 available); any Btk mutation (10 available)
Tg(CD19-BTK*K430R)XK24Rwhe mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• B cell development is partially restored, by about 4-7 fold
• some differentiation into mature B cells occurs
• recirculationg B cell population in the bone marrow is improved
• IgG3 levels remain severely reduced
• improved or restored

neoplasm
N
• tumor suppressor function is restored

hematopoietic system
• B cell development is partially restored, by about 4-7 fold
• some differentiation into mature B cells occurs
• recirculationg B cell population in the bone marrow is improved
• IgG3 levels remain severely reduced
• improved or restored




Genotype
MGI:3709381
cx2
Allelic
Composition
Btktm1Gsv/Y
Tg(CD19-BTK*K430R)XK24Rwhe/?
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Btktm1Gsv mutation (0 available); any Btk mutation (10 available)
Tg(CD19-BTK*K430R)XK24Rwhe mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• calcium signaling of splenic B cells is restored
• B cell apoptosis is reduced compared to similar mice lacking the transgene
• restored B220+ cell numbers peripherally
• deficiency of CD5+ B cells in the peritoneum remains
• differentiation is partially restored
• decreased lambda light chain usage

hematopoietic system
• B cell apoptosis is reduced compared to similar mice lacking the transgene
• restored B220+ cell numbers peripherally
• deficiency of CD5+ B cells in the peritoneum remains
• differentiation is partially restored
• decreased lambda light chain usage

cellular
• B cell apoptosis is reduced compared to similar mice lacking the transgene





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory