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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(tetO-APPSwInd)18Dbo
transgene insertion 18, David R Borchelt
MGI:3709065
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-APPSwInd)18Dbo/0
involves: C3H/HeJ * C57BL/6 * CBA MGI:3709154
tg2
Tg(tetO-APPSwInd)18Dbo/0 involves: C3H/HeJ * C57BL/6J MGI:3709181


Genotype
MGI:3709154
cx1
Allelic
Composition
Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-APPSwInd)18Dbo/0
Genetic
Background
involves: C3H/HeJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Camk2a-tTA)1Mmay mutation (7 available)
Tg(tetO-APPSwInd)18Dbo mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• amyloid burden worsens in untreated animals between 6 and 9 months of age
• with 3 months of doxycyclin treatment beginning at 6 months of age, suppression of transgene synthesis and complete arrest of increase in amyloid pathology is observed compared to untreated mice; however, in these mice no sign of reduction in amyloid burden is observed
• mice produce transgenic APP protein at 10- to 30-fold over endogenous App levels
• sensitivity of transgene suppression by doxycycline is intermediate between mice of line 885 and line 102

homeostasis/metabolism
• amyloid burden worsens in untreated animals between 6 and 9 months of age
• with 3 months of doxycyclin treatment beginning at 6 months of age, suppression of transgene synthesis and complete arrest of increase in amyloid pathology is observed compared to untreated mice; however, in these mice no sign of reduction in amyloid burden is observed

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:109829




Genotype
MGI:3709181
tg2
Allelic
Composition
Tg(tetO-APPSwInd)18Dbo/0
Genetic
Background
involves: C3H/HeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
phenotype not analyzed
• no analysis of single transgenic mice provided





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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory