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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Myo7apolka
polka
MGI:3708382
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Myo7apolka/Myo7apolka involves: C57BL/6J MGI:3709041


Genotype
MGI:3709041
hm1
Allelic
Composition
Myo7apolka/Myo7apolka
Genetic
Background
involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo7apolka mutation (0 available); any Myo7a mutation (69 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• low auditory startle response
• disoriented

hearing/vestibular/ear
• stereociliary bundles are disorganized in all four rows of hair cells of the cochlear sensory epithelium
• often lacking clear polarity
• stereocilia are often short
• auditory threshold of more than 90 dB, indicating that lines are severely hearing impaired in 8- to 12 week old animals

vision/eye
• melanosomes fail to localize to the apical processes of retinal pigment cells

nervous system
• stereociliary bundles are disorganized in all four rows of hair cells of the cochlear sensory epithelium
• often lacking clear polarity
• stereocilia are often short

pigmentation
• melanosomes fail to localize to the apical processes of retinal pigment cells

Mouse Models of Human Disease
OMIM ID Ref(s)
Usher Syndrome, Type I; USH1 276900 J:157102





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory