Mouse Genome Informatics
hm1
    Myo7apolka/Myo7apolka
involves: C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
behavior/neurological
• low auditory startle response
• disoriented

hearing/vestibular/ear
• stereociliary bundles are disorganized in all four rows of hair cells of the cochlear sensory epithelium
• often lacking clear polarity
• stereocilia are often short
• auditory threshold of more than 90 dB, indicating that lines are severely hearing impaired in 8- to 12 week old animals

vision/eye
• melanosomes fail to localize to the apical processes of retinal pigment cells

nervous system
• stereociliary bundles are disorganized in all four rows of hair cells of the cochlear sensory epithelium
• often lacking clear polarity
• stereocilia are often short

pigmentation
• melanosomes fail to localize to the apical processes of retinal pigment cells

Mouse Models of Human Disease
OMIM IDRef(s)
Usher Syndrome, Type I; USH1 276900 J:157102